The effect of panipenem/betamipron on intestinal bacterial flora

Satoshi Iwata, Masahiro Ikeda, Kazuhiko Kawahara, Eiichi Isohata, Yosiaki Kin, Takao Yokota, Yutaka Kusumoto, Yoshitake Sato, Hironobu Akita, Tadao Oikawa, Keisuke Sunakawa, Yasuo Ichihashi

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Abstract

Panipenem/betamipron (PAPM/BP, CS-976), a new parenteral carbapenem antibiotic, was studied for its effect on the intestinal bacterial flora of pediatric patients. The subjects were 8 children admitted for infections (4 males and 4 females, 1 month to 7 years 11 months old, weighing 4.9 to 20.0 kg). PAPM/BP was administered by intravenous drip infusion for 30 minutes at a dose of 10.2 to 21.6 mg/kg, 3 or 4 times a day for a period of 7 to 15 days. Feces were collected from the subjects before, during and after administration of PAPM/BP, and the bacteria in 1 g of feces were identified and counted. The feces were also examined for β-lactamase activity and Clostridium difficile D-1 antigen. Bacterial flora changes in the feces during PAPM/BP administration showed some variation. Five of the 8 Patients showed a significant decrease in Escherichia coli, and some showed a tendency to an increase in Klebsiella oxytoca and Enterobacter cloacae. However, the changes in 3 of the 5 Patients were transient. Variations in the species of genus Enterococcus were observed, but no large change was noted in the total aerobic bacterial counts in this genus. Therefore, there was no significant change in the total aerobic bacterial counts. Regarding anaerobic bacteria, counts of Bacteroides and Eubacterium were decreased in some patients and those of Bifidobacterium showed a significant decrease in 1 patient and little change in the other 7. Consequently, the total anaerobic bacterial counts did not show a large change except for 1 case in which Bifidobacterium alone was detected so there was a significant decrease in the bacterial count. In no case were glucose nonfermentative Gram-negative bacilli or fungi dominant. Although C. difficile and C. difficile D-1 antigen were detected in 5 and 3 cases, respectively, There was no exact relationship between the presence or absence of C. difficile and the characteristics of the feces. The above results suggest that PAPM/BP is a drug with relatively little effect on the intestinal bacterial flora in children.

Original languageEnglish
Pages (from-to)747-762
Number of pages16
JournalCHEMOTHERAPY
Volume40
Issue number6
DOIs
Publication statusPublished - 1992 Jun

Keywords

  • Panipenem/betamipron

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Infectious Diseases
  • Pharmacology
  • Drug Discovery
  • Oncology

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  • Cite this

    Iwata, S., Ikeda, M., Kawahara, K., Isohata, E., Kin, Y., Yokota, T., Kusumoto, Y., Sato, Y., Akita, H., Oikawa, T., Sunakawa, K., & Ichihashi, Y. (1992). The effect of panipenem/betamipron on intestinal bacterial flora. CHEMOTHERAPY, 40(6), 747-762. https://doi.org/10.11250/chemotherapy1953.40.747