TY - JOUR
T1 - The effect of panipenem/betamipron on intestinal bacterial flora
AU - Iwata, Satoshi
AU - Ikeda, Masahiro
AU - Kawahara, Kazuhiko
AU - Isohata, Eiichi
AU - Kin, Yosiaki
AU - Yokota, Takao
AU - Kusumoto, Yutaka
AU - Sato, Yoshitake
AU - Akita, Hironobu
AU - Oikawa, Tadao
AU - Sunakawa, Keisuke
AU - Ichihashi, Yasuo
PY - 1992/6
Y1 - 1992/6
N2 - Panipenem/betamipron (PAPM/BP, CS-976), a new parenteral carbapenem antibiotic, was studied for its effect on the intestinal bacterial flora of pediatric patients. The subjects were 8 children admitted for infections (4 males and 4 females, 1 month to 7 years 11 months old, weighing 4.9 to 20.0 kg). PAPM/BP was administered by intravenous drip infusion for 30 minutes at a dose of 10.2 to 21.6 mg/kg, 3 or 4 times a day for a period of 7 to 15 days. Feces were collected from the subjects before, during and after administration of PAPM/BP, and the bacteria in 1 g of feces were identified and counted. The feces were also examined for β-lactamase activity and Clostridium difficile D-1 antigen. Bacterial flora changes in the feces during PAPM/BP administration showed some variation. Five of the 8 Patients showed a significant decrease in Escherichia coli, and some showed a tendency to an increase in Klebsiella oxytoca and Enterobacter cloacae. However, the changes in 3 of the 5 Patients were transient. Variations in the species of genus Enterococcus were observed, but no large change was noted in the total aerobic bacterial counts in this genus. Therefore, there was no significant change in the total aerobic bacterial counts. Regarding anaerobic bacteria, counts of Bacteroides and Eubacterium were decreased in some patients and those of Bifidobacterium showed a significant decrease in 1 patient and little change in the other 7. Consequently, the total anaerobic bacterial counts did not show a large change except for 1 case in which Bifidobacterium alone was detected so there was a significant decrease in the bacterial count. In no case were glucose nonfermentative Gram-negative bacilli or fungi dominant. Although C. difficile and C. difficile D-1 antigen were detected in 5 and 3 cases, respectively, There was no exact relationship between the presence or absence of C. difficile and the characteristics of the feces. The above results suggest that PAPM/BP is a drug with relatively little effect on the intestinal bacterial flora in children.
AB - Panipenem/betamipron (PAPM/BP, CS-976), a new parenteral carbapenem antibiotic, was studied for its effect on the intestinal bacterial flora of pediatric patients. The subjects were 8 children admitted for infections (4 males and 4 females, 1 month to 7 years 11 months old, weighing 4.9 to 20.0 kg). PAPM/BP was administered by intravenous drip infusion for 30 minutes at a dose of 10.2 to 21.6 mg/kg, 3 or 4 times a day for a period of 7 to 15 days. Feces were collected from the subjects before, during and after administration of PAPM/BP, and the bacteria in 1 g of feces were identified and counted. The feces were also examined for β-lactamase activity and Clostridium difficile D-1 antigen. Bacterial flora changes in the feces during PAPM/BP administration showed some variation. Five of the 8 Patients showed a significant decrease in Escherichia coli, and some showed a tendency to an increase in Klebsiella oxytoca and Enterobacter cloacae. However, the changes in 3 of the 5 Patients were transient. Variations in the species of genus Enterococcus were observed, but no large change was noted in the total aerobic bacterial counts in this genus. Therefore, there was no significant change in the total aerobic bacterial counts. Regarding anaerobic bacteria, counts of Bacteroides and Eubacterium were decreased in some patients and those of Bifidobacterium showed a significant decrease in 1 patient and little change in the other 7. Consequently, the total anaerobic bacterial counts did not show a large change except for 1 case in which Bifidobacterium alone was detected so there was a significant decrease in the bacterial count. In no case were glucose nonfermentative Gram-negative bacilli or fungi dominant. Although C. difficile and C. difficile D-1 antigen were detected in 5 and 3 cases, respectively, There was no exact relationship between the presence or absence of C. difficile and the characteristics of the feces. The above results suggest that PAPM/BP is a drug with relatively little effect on the intestinal bacterial flora in children.
KW - Panipenem/betamipron
UR - http://www.scopus.com/inward/record.url?scp=0026762691&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026762691&partnerID=8YFLogxK
U2 - 10.11250/chemotherapy1953.40.747
DO - 10.11250/chemotherapy1953.40.747
M3 - Article
AN - SCOPUS:0026762691
SN - 0009-3165
VL - 40
SP - 747
EP - 762
JO - CHEMOTHERAPY
JF - CHEMOTHERAPY
IS - 6
ER -
