The Effect of Zaltoprofen on Physiotherapy for Limited Shoulder Movement in Breast Cancer Patients: A Single-Blinded Before-After Trial

Kimitaka Hase, Michiyo Kamisako, Toshiyuki Fujiwara, Tetsuya Tsuji, Meigen Liu

Research output: Contribution to journalArticle

7 Citations (Scopus)


Hase K, Kamisako M, Fujiwara T, Tsuji T, Liu M. The effect of zaltoprofen on physiotherapy for limited should movement in breast cancer patients: a single-blinded before-after trial. Objective: To determine the efficacy of oral administration of zaltoprofen on shoulder range of motion (ROM) exercises for breast cancer patients after surgery. Design: Single-blind, before-after trial. Setting: Rehabilitation facility in a Japanese university hospital. Participants: Forty breast cancer patients (age range, 37-72y) with limited shoulder movement after surgery. Intervention: Single session of physiotherapy (PT) with or without oral administration of zaltoprofen. Main Outcome Measures: Active shoulder ROM in flexion, abduction, and external rotation, as well as subjective pain score during shoulder movements. Results: Active shoulder movements after ingesting a zaltoprofen tablet significantly improved in flexion, abduction (P<.001), and external rotation (P<.005). PT treatment improved flexion and abduction ROM in both the zaltoprofen and control groups and led to significantly larger flexion and abduction movements in the zaltoprofen group than in the control group (P<.01). There were no differences in pain scores between groups, but 2 patients who did not receive zaltoprofen complained of increased pain just after ROM exercises. Conclusion: Zaltoprofen taken orally before ROM exercises for painful shoulder after breast cancer surgery may enhance the effects of PT.

Original languageEnglish
Pages (from-to)1618-1622
Number of pages5
JournalArchives of Physical Medicine and Rehabilitation
Issue number12
Publication statusPublished - 2006 Dec



  • Anti-inflammatory agents, non-steroidal
  • Breast cancer
  • Pain
  • Physiotherapy techniques
  • Range of motion, articular
  • Rehabilitation

ASJC Scopus subject areas

  • Rehabilitation

Cite this