The Effects of Cortical Hypometabolism and Hippocampal Atrophy on Clinical Trajectories in Mild Cognitive Impairment with Suspected Non-Alzheimer's Pathology: A Brief Report

Jun Ku Chung, Eric Plitman, Shinichiro Nakajima, Fernando Caravaggio, Shunichiro Shinagawa, Yusuke Iwata, Philip Gerretsen, Julia Kim, Hiroyoshi Takeuchi, Raihaan Patel, M. Mallar Chakravarty, Antonio Strafella, Ariel Graff-Guerrero

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The clinical and structural trajectories of suspected non-Alzheimer' pathology (SNAP) remain elusive due to its heterogeneous etiology. Baseline and longitudinal clinical (global cognition, daily functioning, symptoms of dementia, and learning memory) and hippocampal volume trajectories over two years were compared between patients with amnestic mild cognitive impairment (aMCI) with SNAP with reduced hippocampal volumes (SNAPHIPPO) and aMCI patients with SNAP without reduced hippocampal volumes. SNAPHIPPO showed overall worse baseline cognitive functions. Longitudinally, SNAPHIPPO showed faster deterioration of clinical symptoms of dementia. Having both hippocampal atrophy and cortical hypometabolism without amyloid pathology may exacerbate symptoms of dementia in aMCI.

Original languageEnglish
Pages (from-to)341-347
Number of pages7
JournalJournal of Alzheimer's Disease
Volume60
Issue number2
DOIs
Publication statusPublished - 2017

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Atrophy
Pathology
Dementia
Cognition
Amyloid
Learning
Cognitive Dysfunction

Keywords

  • Functional decline
  • hippocampus
  • mild cognitive impairment
  • suspected non-Alzheimer's pathology

ASJC Scopus subject areas

  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

The Effects of Cortical Hypometabolism and Hippocampal Atrophy on Clinical Trajectories in Mild Cognitive Impairment with Suspected Non-Alzheimer's Pathology : A Brief Report. / Chung, Jun Ku; Plitman, Eric; Nakajima, Shinichiro; Caravaggio, Fernando; Shinagawa, Shunichiro; Iwata, Yusuke; Gerretsen, Philip; Kim, Julia; Takeuchi, Hiroyoshi; Patel, Raihaan; Chakravarty, M. Mallar; Strafella, Antonio; Graff-Guerrero, Ariel.

In: Journal of Alzheimer's Disease, Vol. 60, No. 2, 2017, p. 341-347.

Research output: Contribution to journalArticle

Chung, JK, Plitman, E, Nakajima, S, Caravaggio, F, Shinagawa, S, Iwata, Y, Gerretsen, P, Kim, J, Takeuchi, H, Patel, R, Chakravarty, MM, Strafella, A & Graff-Guerrero, A 2017, 'The Effects of Cortical Hypometabolism and Hippocampal Atrophy on Clinical Trajectories in Mild Cognitive Impairment with Suspected Non-Alzheimer's Pathology: A Brief Report', Journal of Alzheimer's Disease, vol. 60, no. 2, pp. 341-347. https://doi.org/10.3233/JAD-170098
Chung, Jun Ku ; Plitman, Eric ; Nakajima, Shinichiro ; Caravaggio, Fernando ; Shinagawa, Shunichiro ; Iwata, Yusuke ; Gerretsen, Philip ; Kim, Julia ; Takeuchi, Hiroyoshi ; Patel, Raihaan ; Chakravarty, M. Mallar ; Strafella, Antonio ; Graff-Guerrero, Ariel. / The Effects of Cortical Hypometabolism and Hippocampal Atrophy on Clinical Trajectories in Mild Cognitive Impairment with Suspected Non-Alzheimer's Pathology : A Brief Report. In: Journal of Alzheimer's Disease. 2017 ; Vol. 60, No. 2. pp. 341-347.
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