The Effects of Direct Oral Anticoagulants, Warfarin, Aspirin and Thienopyridine on the Performance of Immunochemical, Faecal, Occult Blood Tests

Ryota Niikura, Atsuo Yamada, Mitsuhiro Fujishiro, Kiyohito Tanaka, Koji Matsuda, Yutaka Saito, Kazuo Ohtsuka, Ichiro Oda, Chikatoshi Katada, Masayuki Kato, Mitsuhiro Kida, Kiyonori Kobayashi, Shu Hoteya, Takahiro Horimatsu, Shinya Kodashima, Takahisa Matsuda, Manabu Muto, Hironori Yamamoto, Shomei Ryozawa, Ryuichi IwakiriHiromu Kutsumi, Hiroaki Miyata, Mototsugu Kato, Ken Haruma, Kazuma Fujimoto, Naomi Uemura, Michio Kaminishi, Tomohiro Shinozaki, Hisao Tajiri, Kazuhiko Koike

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Aim: To clarify whether antithrombotic drugs affect diagnosis using the immunochemical faecal occult blood test -(iFOBT) of colorectal neoplasia. Methods: Using the Japan Endoscopy Database from 8 centres between 2015 and 2017, we analyzed data about patients who were iFOBT positive and had received direct oral anticoagulants (DOAC), warfarin, aspirin or thienopyridine. One-to-one matching-analogue propensity score weighted analyses were performed to compare the positive predictive value (PPV) of all neoplasms, invasive and non-invasive colorectal cancers and adenomas between drug users and non-users. All neoplasms included invasive and non-invasive colorectal cancer, and adenomas. Results: We analyzed 197 DOAC users and 196 non-users, 153 warfarin users and 153 non-users, 408 aspirin users and 415 non-users, and 97 thienopyridine users and 97 non-users. No significant differences were observed in the PPV for all neoplasms (56.67 vs. 50.43%), invasive cancer (4.32 vs. 3.53%), non-invasive cancer (15.58 vs. 15.56%) or adenoma (53.13 vs. 48.09%) between the DOAC user and non-user groups. No significant differences were observed in the PPV for all neoplasia, invasive and non-invasive cancer, or adenoma between warfarin, aspirin and thienopyridine use and non-users. Conclusions: DOAC, warfarin, aspirin and thienopyridine use did not decrease the PPVs of the iFOBT used to evaluate all colorectal neoplasia.

Original languageEnglish
Pages (from-to)117-126
Number of pages10
JournalDigestion
Volume100
Issue number2
DOIs
Publication statusPublished - 2019 Aug 1
Externally publishedYes

Fingerprint

Occult Blood
Hematologic Tests
Warfarin
Anticoagulants
Aspirin
Adenoma
Neoplasms
Colorectal Neoplasms
thienopyridine
Propensity Score
Drug Users
Endoscopy
Japan
Databases

Keywords

  • Colorectal neoplasia
  • Direct oral anticoagulant
  • Immunochemical faecal occult blood test

ASJC Scopus subject areas

  • Gastroenterology

Cite this

The Effects of Direct Oral Anticoagulants, Warfarin, Aspirin and Thienopyridine on the Performance of Immunochemical, Faecal, Occult Blood Tests. / Niikura, Ryota; Yamada, Atsuo; Fujishiro, Mitsuhiro; Tanaka, Kiyohito; Matsuda, Koji; Saito, Yutaka; Ohtsuka, Kazuo; Oda, Ichiro; Katada, Chikatoshi; Kato, Masayuki; Kida, Mitsuhiro; Kobayashi, Kiyonori; Hoteya, Shu; Horimatsu, Takahiro; Kodashima, Shinya; Matsuda, Takahisa; Muto, Manabu; Yamamoto, Hironori; Ryozawa, Shomei; Iwakiri, Ryuichi; Kutsumi, Hiromu; Miyata, Hiroaki; Kato, Mototsugu; Haruma, Ken; Fujimoto, Kazuma; Uemura, Naomi; Kaminishi, Michio; Shinozaki, Tomohiro; Tajiri, Hisao; Koike, Kazuhiko.

In: Digestion, Vol. 100, No. 2, 01.08.2019, p. 117-126.

Research output: Contribution to journalArticle

Niikura, R, Yamada, A, Fujishiro, M, Tanaka, K, Matsuda, K, Saito, Y, Ohtsuka, K, Oda, I, Katada, C, Kato, M, Kida, M, Kobayashi, K, Hoteya, S, Horimatsu, T, Kodashima, S, Matsuda, T, Muto, M, Yamamoto, H, Ryozawa, S, Iwakiri, R, Kutsumi, H, Miyata, H, Kato, M, Haruma, K, Fujimoto, K, Uemura, N, Kaminishi, M, Shinozaki, T, Tajiri, H & Koike, K 2019, 'The Effects of Direct Oral Anticoagulants, Warfarin, Aspirin and Thienopyridine on the Performance of Immunochemical, Faecal, Occult Blood Tests', Digestion, vol. 100, no. 2, pp. 117-126. https://doi.org/10.1159/000494251
Niikura, Ryota ; Yamada, Atsuo ; Fujishiro, Mitsuhiro ; Tanaka, Kiyohito ; Matsuda, Koji ; Saito, Yutaka ; Ohtsuka, Kazuo ; Oda, Ichiro ; Katada, Chikatoshi ; Kato, Masayuki ; Kida, Mitsuhiro ; Kobayashi, Kiyonori ; Hoteya, Shu ; Horimatsu, Takahiro ; Kodashima, Shinya ; Matsuda, Takahisa ; Muto, Manabu ; Yamamoto, Hironori ; Ryozawa, Shomei ; Iwakiri, Ryuichi ; Kutsumi, Hiromu ; Miyata, Hiroaki ; Kato, Mototsugu ; Haruma, Ken ; Fujimoto, Kazuma ; Uemura, Naomi ; Kaminishi, Michio ; Shinozaki, Tomohiro ; Tajiri, Hisao ; Koike, Kazuhiko. / The Effects of Direct Oral Anticoagulants, Warfarin, Aspirin and Thienopyridine on the Performance of Immunochemical, Faecal, Occult Blood Tests. In: Digestion. 2019 ; Vol. 100, No. 2. pp. 117-126.
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abstract = "Aim: To clarify whether antithrombotic drugs affect diagnosis using the immunochemical faecal occult blood test -(iFOBT) of colorectal neoplasia. Methods: Using the Japan Endoscopy Database from 8 centres between 2015 and 2017, we analyzed data about patients who were iFOBT positive and had received direct oral anticoagulants (DOAC), warfarin, aspirin or thienopyridine. One-to-one matching-analogue propensity score weighted analyses were performed to compare the positive predictive value (PPV) of all neoplasms, invasive and non-invasive colorectal cancers and adenomas between drug users and non-users. All neoplasms included invasive and non-invasive colorectal cancer, and adenomas. Results: We analyzed 197 DOAC users and 196 non-users, 153 warfarin users and 153 non-users, 408 aspirin users and 415 non-users, and 97 thienopyridine users and 97 non-users. No significant differences were observed in the PPV for all neoplasms (56.67 vs. 50.43{\%}), invasive cancer (4.32 vs. 3.53{\%}), non-invasive cancer (15.58 vs. 15.56{\%}) or adenoma (53.13 vs. 48.09{\%}) between the DOAC user and non-user groups. No significant differences were observed in the PPV for all neoplasia, invasive and non-invasive cancer, or adenoma between warfarin, aspirin and thienopyridine use and non-users. Conclusions: DOAC, warfarin, aspirin and thienopyridine use did not decrease the PPVs of the iFOBT used to evaluate all colorectal neoplasia.",
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T1 - The Effects of Direct Oral Anticoagulants, Warfarin, Aspirin and Thienopyridine on the Performance of Immunochemical, Faecal, Occult Blood Tests

AU - Niikura, Ryota

AU - Yamada, Atsuo

AU - Fujishiro, Mitsuhiro

AU - Tanaka, Kiyohito

AU - Matsuda, Koji

AU - Saito, Yutaka

AU - Ohtsuka, Kazuo

AU - Oda, Ichiro

AU - Katada, Chikatoshi

AU - Kato, Masayuki

AU - Kida, Mitsuhiro

AU - Kobayashi, Kiyonori

AU - Hoteya, Shu

AU - Horimatsu, Takahiro

AU - Kodashima, Shinya

AU - Matsuda, Takahisa

AU - Muto, Manabu

AU - Yamamoto, Hironori

AU - Ryozawa, Shomei

AU - Iwakiri, Ryuichi

AU - Kutsumi, Hiromu

AU - Miyata, Hiroaki

AU - Kato, Mototsugu

AU - Haruma, Ken

AU - Fujimoto, Kazuma

AU - Uemura, Naomi

AU - Kaminishi, Michio

AU - Shinozaki, Tomohiro

AU - Tajiri, Hisao

AU - Koike, Kazuhiko

PY - 2019/8/1

Y1 - 2019/8/1

N2 - Aim: To clarify whether antithrombotic drugs affect diagnosis using the immunochemical faecal occult blood test -(iFOBT) of colorectal neoplasia. Methods: Using the Japan Endoscopy Database from 8 centres between 2015 and 2017, we analyzed data about patients who were iFOBT positive and had received direct oral anticoagulants (DOAC), warfarin, aspirin or thienopyridine. One-to-one matching-analogue propensity score weighted analyses were performed to compare the positive predictive value (PPV) of all neoplasms, invasive and non-invasive colorectal cancers and adenomas between drug users and non-users. All neoplasms included invasive and non-invasive colorectal cancer, and adenomas. Results: We analyzed 197 DOAC users and 196 non-users, 153 warfarin users and 153 non-users, 408 aspirin users and 415 non-users, and 97 thienopyridine users and 97 non-users. No significant differences were observed in the PPV for all neoplasms (56.67 vs. 50.43%), invasive cancer (4.32 vs. 3.53%), non-invasive cancer (15.58 vs. 15.56%) or adenoma (53.13 vs. 48.09%) between the DOAC user and non-user groups. No significant differences were observed in the PPV for all neoplasia, invasive and non-invasive cancer, or adenoma between warfarin, aspirin and thienopyridine use and non-users. Conclusions: DOAC, warfarin, aspirin and thienopyridine use did not decrease the PPVs of the iFOBT used to evaluate all colorectal neoplasia.

AB - Aim: To clarify whether antithrombotic drugs affect diagnosis using the immunochemical faecal occult blood test -(iFOBT) of colorectal neoplasia. Methods: Using the Japan Endoscopy Database from 8 centres between 2015 and 2017, we analyzed data about patients who were iFOBT positive and had received direct oral anticoagulants (DOAC), warfarin, aspirin or thienopyridine. One-to-one matching-analogue propensity score weighted analyses were performed to compare the positive predictive value (PPV) of all neoplasms, invasive and non-invasive colorectal cancers and adenomas between drug users and non-users. All neoplasms included invasive and non-invasive colorectal cancer, and adenomas. Results: We analyzed 197 DOAC users and 196 non-users, 153 warfarin users and 153 non-users, 408 aspirin users and 415 non-users, and 97 thienopyridine users and 97 non-users. No significant differences were observed in the PPV for all neoplasms (56.67 vs. 50.43%), invasive cancer (4.32 vs. 3.53%), non-invasive cancer (15.58 vs. 15.56%) or adenoma (53.13 vs. 48.09%) between the DOAC user and non-user groups. No significant differences were observed in the PPV for all neoplasia, invasive and non-invasive cancer, or adenoma between warfarin, aspirin and thienopyridine use and non-users. Conclusions: DOAC, warfarin, aspirin and thienopyridine use did not decrease the PPVs of the iFOBT used to evaluate all colorectal neoplasia.

KW - Colorectal neoplasia

KW - Direct oral anticoagulant

KW - Immunochemical faecal occult blood test

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