The Effects of Direct Oral Anticoagulants, Warfarin, Aspirin and Thienopyridine on the Performance of Immunochemical, Faecal, Occult Blood Tests

Ryota Niikura, Atsuo Yamada, Mitsuhiro Fujishiro, Kiyohito Tanaka, Koji Matsuda, Yutaka Saito, Kazuo Ohtsuka, Ichiro Oda, Chikatoshi Katada, Masayuki Kato, Mitsuhiro Kida, Kiyonori Kobayashi, Shu Hoteya, Takahiro Horimatsu, Shinya Kodashima, Takahisa Matsuda, Manabu Muto, Hironori Yamamoto, Shomei Ryozawa, Ryuichi IwakiriHiromu Kutsumi, Hiroaki Miyata, Mototsugu Kato, Ken Haruma, Kazuma Fujimoto, Naomi Uemura, Michio Kaminishi, Tomohiro Shinozaki, Hisao Tajiri, Kazuhiko Koike

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Aim: To clarify whether antithrombotic drugs affect diagnosis using the immunochemical faecal occult blood test -(iFOBT) of colorectal neoplasia. Methods: Using the Japan Endoscopy Database from 8 centres between 2015 and 2017, we analyzed data about patients who were iFOBT positive and had received direct oral anticoagulants (DOAC), warfarin, aspirin or thienopyridine. One-to-one matching-analogue propensity score weighted analyses were performed to compare the positive predictive value (PPV) of all neoplasms, invasive and non-invasive colorectal cancers and adenomas between drug users and non-users. All neoplasms included invasive and non-invasive colorectal cancer, and adenomas. Results: We analyzed 197 DOAC users and 196 non-users, 153 warfarin users and 153 non-users, 408 aspirin users and 415 non-users, and 97 thienopyridine users and 97 non-users. No significant differences were observed in the PPV for all neoplasms (56.67 vs. 50.43%), invasive cancer (4.32 vs. 3.53%), non-invasive cancer (15.58 vs. 15.56%) or adenoma (53.13 vs. 48.09%) between the DOAC user and non-user groups. No significant differences were observed in the PPV for all neoplasia, invasive and non-invasive cancer, or adenoma between warfarin, aspirin and thienopyridine use and non-users. Conclusions: DOAC, warfarin, aspirin and thienopyridine use did not decrease the PPVs of the iFOBT used to evaluate all colorectal neoplasia.

Original languageEnglish
Pages (from-to)117-126
Number of pages10
JournalDigestion
Volume100
Issue number2
DOIs
Publication statusPublished - 2019 Aug 1
Externally publishedYes

Keywords

  • Colorectal neoplasia
  • Direct oral anticoagulant
  • Immunochemical faecal occult blood test

ASJC Scopus subject areas

  • Gastroenterology

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  • Cite this

    Niikura, R., Yamada, A., Fujishiro, M., Tanaka, K., Matsuda, K., Saito, Y., Ohtsuka, K., Oda, I., Katada, C., Kato, M., Kida, M., Kobayashi, K., Hoteya, S., Horimatsu, T., Kodashima, S., Matsuda, T., Muto, M., Yamamoto, H., Ryozawa, S., ... Koike, K. (2019). The Effects of Direct Oral Anticoagulants, Warfarin, Aspirin and Thienopyridine on the Performance of Immunochemical, Faecal, Occult Blood Tests. Digestion, 100(2), 117-126. https://doi.org/10.1159/000494251