The effects of flow on the transport of potassium ions through the walls of single perfused frog mesenteric capillaries

M. Kajimura, S. D. Head, C. C. Michel

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

1. We have investigated the effects of varying flow velocity upon permeability to potassium ions (P(K)) of single perfused mesenteric microvessels in pithed frogs. 2. P(K) was estimated using a development of the single bolus microperfusion technique at chosen flow velocities (U) in the range of 150-7000 μm s-1. 3. In thirty-seven out of forty-three vessels, there was a strong positive correlation between P(K) and U. Average values (median) for P(K)(μm s-1) were related to U (μm s-1) by the expression: P(K) = 0.0043U + 4.05 (n = 43). 4. The correlation between P(K) and U was independent of microvascular pressure (and hence fluid filtration) over the range of 5-70 cmH2O. 5. The correlation between P(K) and U was independent of the potassium concentration in the bolus over the range of 2-40 mmol l-1 and of the direction of the potassium flux through the capillary walls.

Original languageEnglish
Pages (from-to)707-718
Number of pages12
JournalJournal of Physiology
Volume511
Issue number3
DOIs
Publication statusPublished - 1998 Sep 15
Externally publishedYes

ASJC Scopus subject areas

  • Physiology

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