The efficacy, safety, and pharmacokinetics of biapenem administered thrice daily for the treatment of pneumonia in the elderly

Ho Namkoong, Youjyu Kameyama, Hiroyuki Yasuda, Sohei Nakayama, Hiroshi Kaneko, Chieko Kawashima, Tomoko Terajima, Kayoko Maezawa, Takeshi Hayashi, Mitsuru Sandoh, Makoto Ishii, Sadatomo Tasaka, Akiko Kanayama, Intetsu Kobayashi, Tomoko Betsuyaku, Junko Kizu, Satoshi Iwata, Yoshitake Sato, Naoki Hasegawa

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Abstract

Biapenem has been widely used to treat bacterial pneumonia; however, there is little information concerning its efficacy and safety in elderly patients. Based on pharmacokinetic-pharmacodynamic theory, administration of biapenem thrice rather than twice daily would be expected to be more effective because of longer time above the minimum inhibitory concentration. In this study, we aimed to evaluate the efficacy, safety, and pharmacokinetics of biapenem (300 mg) administered thrice daily in pneumonic patients aged 65 years or older. Biapenem was effective in 22 of 25 patients, as assessed by the improvement in clinical symptoms and/or the eradication of the causative organisms, and caused no serious adverse events. The pharmacokinetic profile was established based on simulations using a modeling program. Among 17 patients whose causative organisms were detected, time above the minimum inhibitory concentration was estimated to be 100% in 16 patients, all of whom showed clinical improvement. The results of this study confirmed the efficacy and safety of 300 mg of biapenem administered thrice daily for the treatment of pneumonia in elderly patients.

Original languageEnglish
Pages (from-to)356-360
Number of pages5
JournalJournal of Infection and Chemotherapy
Volume20
Issue number6
DOIs
Publication statusPublished - 2014 Jun

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Keywords

  • Biapenem
  • Elderly patients
  • Pharmacokinetics-pharmacodynamics (PK-PD)
  • Pneumonia

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Namkoong, H., Kameyama, Y., Yasuda, H., Nakayama, S., Kaneko, H., Kawashima, C., Terajima, T., Maezawa, K., Hayashi, T., Sandoh, M., Ishii, M., Tasaka, S., Kanayama, A., Kobayashi, I., Betsuyaku, T., Kizu, J., Iwata, S., Sato, Y., & Hasegawa, N. (2014). The efficacy, safety, and pharmacokinetics of biapenem administered thrice daily for the treatment of pneumonia in the elderly. Journal of Infection and Chemotherapy, 20(6), 356-360. https://doi.org/10.1016/j.jiac.2013.12.010