The entire nucleotide sequence of baboon endogenous virus DNA

A chimeric genome structure of murine type C and simian type D retroviruses

Shingo Kato, Koichi Matsuo, Naomi Takahashi, Toshiya Takano, Naoyuki Nishimura

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

We determined the complete nucleotide sequence of baboon endogenous virus (BaEV) strain M7. The total length of the retroviral DNA is 8,507 base pairs. The order of viral proteins encoded is NH2-pl2-pl5-p30-plO-COOH in the gag, NH2-protease-reverse transcriptase-endonuclease-COOH in the pol, and NH2-gp70-p20E-COOH in the env genes. The transmembrane env protein, p20E, contains an amino acid sequence closely related to the “immunosuppressive peptide.” Uncharacteristically, the pol and env genes do not overlap and are translated in the same frame. The deduced amino acid sequence of BaEV is related to 1) reticuloendotheliosis virus strain A in both the pol and env regions, 2) murine leukemia viruses in the pol but not in the env region, 3) simian type D retroviruses in the env but not in the pol region. This suggests that env genes in retroviruses may have been independently interchanged during evolution.

Original languageEnglish
Pages (from-to)127-137
Number of pages11
JournalThe Japanese Journal of Genetics
Volume62
Issue number2
DOIs
Publication statusPublished - 1987

Fingerprint

Simian Retroviruses
env Genes
DNA Viruses
Papio
Genome
Amino Acid Sequence
Reticuloendotheliosis virus
pol Genes
env Gene Products
Viruses
Murine Leukemia Viruses
Endonucleases
RNA-Directed DNA Polymerase
Viral Proteins
Retroviridae
Immunosuppressive Agents
Base Pairing
Peptide Hydrolases
Peptides
DNA

ASJC Scopus subject areas

  • Genetics

Cite this

The entire nucleotide sequence of baboon endogenous virus DNA : A chimeric genome structure of murine type C and simian type D retroviruses. / Kato, Shingo; Matsuo, Koichi; Takahashi, Naomi; Takano, Toshiya; Nishimura, Naoyuki.

In: The Japanese Journal of Genetics, Vol. 62, No. 2, 1987, p. 127-137.

Research output: Contribution to journalArticle

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