TY - JOUR
T1 - The evaluation of the treatment response in obstructive meibomian gland disease by in vivo laser confocal microscopy
AU - Matsumoto, Yukihiro
AU - Shigeno, Yuta
AU - Sato, Enrique Adan
AU - Ibrahim, Osama M.A.
AU - Saiki, Megumi
AU - Negishi, Kazuno
AU - Ogawa, Yoko
AU - Dogru, Murat
AU - Tsubota, Kazuo
N1 - Funding Information:
Acknowledgement The authors have no proprietary interest in any of the products mentioned in this paper. Presented at the 32nd Japan Cornea Conference, 28 February-1 March 2008, Urayasu, Japan. This work was supported in part by research grants from J&J Vision Care Company. Yukihiro Matsumoto and Yuta Shigeno contributed equally to the work and request acknowledgement of double first authorship.
PY - 2009/6
Y1 - 2009/6
N2 - Purpose: To evaluate the status of periglandular inflammation, ocular surface and tear function alterations in patients with obstructive meibomian gland disease (OMGD) by in vivo confocal microscopy before and after anti-inflammatory treatment, and to compare the results with patients receiving only topical non-preserved artificial tears and sodium hyaluronate eye drops without anti-inflammatory agents. Methods: Thirty-two eyes of 16 OMGD patients receiving anti-inflammatory treatment (treatment group) and 22 eyes of 11 OMGD patients receiving only topical non-preserved artificial tears and sodium hyaluronate eye drops (control group) were recruited in this prospective study. All subjects underwent slit-lamp examinations, tear film break-up time (BUT) measurements, fluorescein and Rose-Bengal stainings, Schirmer test I without anesthesia, transillumination of the lids (meibography), and in vivo laser confocal microscopy of the lids (HRTII-RCM). Results: The mean BUT, fluorescein staining scores, and inflammatory cell densities observed by in vivo confocal microscopy improved significantly in the group receiving anti-inflammatory treatment (p<0.05), whereas no significant alterations of these parameters were observed in the group not receiving anti-inflammatory agents (p>0.05). Conclusions: In vivo confocal microscopy was able to effectively demonstrate the treatment responses in patients with OMGD. Inflammatory cell density calculation seems to be a promising new parameter of in vivo confocal microscopy in the evaluation of treatment responses.
AB - Purpose: To evaluate the status of periglandular inflammation, ocular surface and tear function alterations in patients with obstructive meibomian gland disease (OMGD) by in vivo confocal microscopy before and after anti-inflammatory treatment, and to compare the results with patients receiving only topical non-preserved artificial tears and sodium hyaluronate eye drops without anti-inflammatory agents. Methods: Thirty-two eyes of 16 OMGD patients receiving anti-inflammatory treatment (treatment group) and 22 eyes of 11 OMGD patients receiving only topical non-preserved artificial tears and sodium hyaluronate eye drops (control group) were recruited in this prospective study. All subjects underwent slit-lamp examinations, tear film break-up time (BUT) measurements, fluorescein and Rose-Bengal stainings, Schirmer test I without anesthesia, transillumination of the lids (meibography), and in vivo laser confocal microscopy of the lids (HRTII-RCM). Results: The mean BUT, fluorescein staining scores, and inflammatory cell densities observed by in vivo confocal microscopy improved significantly in the group receiving anti-inflammatory treatment (p<0.05), whereas no significant alterations of these parameters were observed in the group not receiving anti-inflammatory agents (p>0.05). Conclusions: In vivo confocal microscopy was able to effectively demonstrate the treatment responses in patients with OMGD. Inflammatory cell density calculation seems to be a promising new parameter of in vivo confocal microscopy in the evaluation of treatment responses.
KW - Confocal microscopy
KW - Inflammation
KW - Meibomian gland dysfunction
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U2 - 10.1007/s00417-008-1017-y
DO - 10.1007/s00417-008-1017-y
M3 - Article
C2 - 19101718
AN - SCOPUS:67349083532
SN - 0065-6100
VL - 247
SP - 821
EP - 829
JO - Albrecht von Graefes Archiv für Klinische und Experimentelle Ophthalmologie
JF - Albrecht von Graefes Archiv für Klinische und Experimentelle Ophthalmologie
IS - 6
ER -