TY - JOUR
T1 - The ever-expanding function of NOD2
T2 - Autophagy, viral recognition, and T cell activation
AU - Shaw, Michael H.
AU - Kamada, Nobuhiko
AU - Warner, Neil
AU - Kim, Yun Gi
AU - Nuñez, Gabriel
N1 - Funding Information:
We apologize to investigators whose work was not explicitly cited because of space constrains. The authors’ work is supported by NIH grants DK61707, AR051790, AI063331, AR059688 and DK091191. M.H.S. was supported by training grant 2T32 HL007517 from the NIH, N.K. by a Fellowship from the Uehara Memorial Foundation, Y.-G.K. by training funds from the University of Michigan Comprehensive Cancer Center. N.W. is supported by a Center for Genetics in Health and Medicine (CGHM) Postdoctoral Fellowship Award.
PY - 2011/2
Y1 - 2011/2
N2 - The identification of several families of innate pattern recognition receptors has greatly enhanced our understanding of the host innate immune response against a variety of pathogens. One such family of innate receptors is the nucleotide-binding domain and leucine rich repeat containing receptors (NLRs). NOD2 has been characterized as a cytosolic sensor of bacteria peptidoglycan (PGN). For almost 10 years, NOD2 was assigned with the function of mediating the RICK- and nuclear factor-κB induced proinflammatory response triggered by PGN. Recent studies have extended the biological activity of NOD2 to include the induction of autophagy and antiviral responses, as well as mediating direct T cell activation. Here, we highlight and discuss these new findings in the context of immune activation and pathogen detection.
AB - The identification of several families of innate pattern recognition receptors has greatly enhanced our understanding of the host innate immune response against a variety of pathogens. One such family of innate receptors is the nucleotide-binding domain and leucine rich repeat containing receptors (NLRs). NOD2 has been characterized as a cytosolic sensor of bacteria peptidoglycan (PGN). For almost 10 years, NOD2 was assigned with the function of mediating the RICK- and nuclear factor-κB induced proinflammatory response triggered by PGN. Recent studies have extended the biological activity of NOD2 to include the induction of autophagy and antiviral responses, as well as mediating direct T cell activation. Here, we highlight and discuss these new findings in the context of immune activation and pathogen detection.
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U2 - 10.1016/j.it.2010.12.007
DO - 10.1016/j.it.2010.12.007
M3 - Review article
C2 - 21251876
AN - SCOPUS:79751524964
SN - 1471-4906
VL - 32
SP - 73
EP - 79
JO - Trends in Immunology
JF - Trends in Immunology
IS - 2
ER -