The ever-expanding function of NOD2: Autophagy, viral recognition, and T cell activation

Michael H. Shaw, Nobuhiko Kamada, Neil Warner, Yun Gi Kim, Gabriel Nuñez

Research output: Contribution to journalReview article

52 Citations (Scopus)


The identification of several families of innate pattern recognition receptors has greatly enhanced our understanding of the host innate immune response against a variety of pathogens. One such family of innate receptors is the nucleotide-binding domain and leucine rich repeat containing receptors (NLRs). NOD2 has been characterized as a cytosolic sensor of bacteria peptidoglycan (PGN). For almost 10 years, NOD2 was assigned with the function of mediating the RICK- and nuclear factor-κB induced proinflammatory response triggered by PGN. Recent studies have extended the biological activity of NOD2 to include the induction of autophagy and antiviral responses, as well as mediating direct T cell activation. Here, we highlight and discuss these new findings in the context of immune activation and pathogen detection.

Original languageEnglish
Pages (from-to)73-79
Number of pages7
JournalTrends in Immunology
Issue number2
Publication statusPublished - 2011 Feb 1
Externally publishedYes


ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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