The expression of granulysin in systemic anaplastic large cell lymphoma in childhood

Noriko Kitamura; Yohko U. Katagiri; Mitsuko Itagaki; Yoshitaka Miyagawa; Keiko Onda; Hajime Okita; Akio Mori; Junichiro Fujimoto; Nobutaka Kiyokawa

doi:10.1016/j.leukres.2009.01.032

The expression of granulysin in systemic anaplastic large cell lymphoma in childhood

Noriko Kitamura, Yohko U. Katagiri, Mitsuko Itagaki, Yoshitaka Miyagawa, Keiko Onda, Hajime Okita, Akio Mori, Junichiro Fujimoto, Nobutaka Kiyokawa

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

The expression of granulysin, a cytolytic protein produced by activated T and NK cells, has been revealed to be correlated with the prognosis of some adult cancer patients. By examination on various childhood lymphoma tissues, we found that granulysin level was especially high in systemic anaplastic large cell lymphoma (ALCL) cases, whereas no close correlation with the expression of CD96, a marker for activated T and NK cells, was observed. We further demonstrated that both ALCL cells in biopsy specimens and cell lines established from ALCL express granulysin, indicating some correlation of granulysin with biological features of ALCL.

Original language	English
Pages (from-to)	908-912
Number of pages	5
Journal	Leukemia Research
Volume	33
Issue number	7
DOIs	https://doi.org/10.1016/j.leukres.2009.01.032
Publication status	Published - 2009 Jul
Externally published	Yes

Keywords

CD96
Cell origin
Childhood lymphomas
Granulysin
NK cells
Systemic anaplastic large cell lymphoma
T cells

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.leukres.2009.01.032

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title = "The expression of granulysin in systemic anaplastic large cell lymphoma in childhood",

abstract = "The expression of granulysin, a cytolytic protein produced by activated T and NK cells, has been revealed to be correlated with the prognosis of some adult cancer patients. By examination on various childhood lymphoma tissues, we found that granulysin level was especially high in systemic anaplastic large cell lymphoma (ALCL) cases, whereas no close correlation with the expression of CD96, a marker for activated T and NK cells, was observed. We further demonstrated that both ALCL cells in biopsy specimens and cell lines established from ALCL express granulysin, indicating some correlation of granulysin with biological features of ALCL.",

keywords = "CD96, Cell origin, Childhood lymphomas, Granulysin, NK cells, Systemic anaplastic large cell lymphoma, T cells",

author = "Noriko Kitamura and Katagiri, {Yohko U.} and Mitsuko Itagaki and Yoshitaka Miyagawa and Keiko Onda and Hajime Okita and Akio Mori and Junichiro Fujimoto and Nobutaka Kiyokawa",

note = "Funding Information: We thank S. Yamauchi for excellent secretarial work. This work was supported in part by a grant from JSPS. KAKENHI (No. 18790750) and Health and Labour Sciences Research Grants the 3rd term comprehensive 10-year-strategy for cancer control from the Ministry of Health, Labour and Welfare of Japan (No. H19-010). ",

year = "2009",

month = jul,

doi = "10.1016/j.leukres.2009.01.032",

language = "English",

volume = "33",

pages = "908--912",

journal = "Leukemia Research",

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T1 - The expression of granulysin in systemic anaplastic large cell lymphoma in childhood

AU - Kitamura, Noriko

AU - Katagiri, Yohko U.

AU - Itagaki, Mitsuko

AU - Miyagawa, Yoshitaka

AU - Onda, Keiko

AU - Okita, Hajime

AU - Mori, Akio

AU - Fujimoto, Junichiro

AU - Kiyokawa, Nobutaka

N1 - Funding Information: We thank S. Yamauchi for excellent secretarial work. This work was supported in part by a grant from JSPS. KAKENHI (No. 18790750) and Health and Labour Sciences Research Grants the 3rd term comprehensive 10-year-strategy for cancer control from the Ministry of Health, Labour and Welfare of Japan (No. H19-010).

PY - 2009/7

Y1 - 2009/7

N2 - The expression of granulysin, a cytolytic protein produced by activated T and NK cells, has been revealed to be correlated with the prognosis of some adult cancer patients. By examination on various childhood lymphoma tissues, we found that granulysin level was especially high in systemic anaplastic large cell lymphoma (ALCL) cases, whereas no close correlation with the expression of CD96, a marker for activated T and NK cells, was observed. We further demonstrated that both ALCL cells in biopsy specimens and cell lines established from ALCL express granulysin, indicating some correlation of granulysin with biological features of ALCL.

AB - The expression of granulysin, a cytolytic protein produced by activated T and NK cells, has been revealed to be correlated with the prognosis of some adult cancer patients. By examination on various childhood lymphoma tissues, we found that granulysin level was especially high in systemic anaplastic large cell lymphoma (ALCL) cases, whereas no close correlation with the expression of CD96, a marker for activated T and NK cells, was observed. We further demonstrated that both ALCL cells in biopsy specimens and cell lines established from ALCL express granulysin, indicating some correlation of granulysin with biological features of ALCL.

KW - CD96

KW - Cell origin

KW - Childhood lymphomas

KW - Granulysin

KW - NK cells

KW - Systemic anaplastic large cell lymphoma

KW - T cells

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DO - 10.1016/j.leukres.2009.01.032

M3 - Article

C2 - 19243819

AN - SCOPUS:67349247372

SN - 0145-2126

VL - 33

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EP - 912

JO - Leukemia Research

JF - Leukemia Research

IS - 7

ER -

The expression of granulysin in systemic anaplastic large cell lymphoma in childhood

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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