The expression of granulysin in systemic anaplastic large cell lymphoma in childhood

Noriko Kitamura, Yohko U. Katagiri, Mitsuko Itagaki, Yoshitaka Miyagawa, Keiko Onda, Hajime Okita, Akio Mori, Junichiro Fujimoto, Nobutaka Kiyokawa

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12 Citations (Scopus)

Abstract

The expression of granulysin, a cytolytic protein produced by activated T and NK cells, has been revealed to be correlated with the prognosis of some adult cancer patients. By examination on various childhood lymphoma tissues, we found that granulysin level was especially high in systemic anaplastic large cell lymphoma (ALCL) cases, whereas no close correlation with the expression of CD96, a marker for activated T and NK cells, was observed. We further demonstrated that both ALCL cells in biopsy specimens and cell lines established from ALCL express granulysin, indicating some correlation of granulysin with biological features of ALCL.

Original languageEnglish
Pages (from-to)908-912
Number of pages5
JournalLeukemia Research
Volume33
Issue number7
DOIs
Publication statusPublished - 2009 Jul 1
Externally publishedYes

Keywords

  • CD96
  • Cell origin
  • Childhood lymphomas
  • Granulysin
  • NK cells
  • Systemic anaplastic large cell lymphoma
  • T cells

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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  • Cite this

    Kitamura, N., Katagiri, Y. U., Itagaki, M., Miyagawa, Y., Onda, K., Okita, H., Mori, A., Fujimoto, J., & Kiyokawa, N. (2009). The expression of granulysin in systemic anaplastic large cell lymphoma in childhood. Leukemia Research, 33(7), 908-912. https://doi.org/10.1016/j.leukres.2009.01.032