The factors related to the poor ADL in the patients with osteoporotic vertebral fracture after instrumentation surgery

Kazuma Murata, Yuji Matsuoka, Hirosuke Nishimura, Kenji Endo, Hidekazu Suzuki, Taichiro Takamatsu, Yasunobu Sawaji, Takato Aihara, Takuya Kusakabe, Asato Maekawa, Kengo Yamamoto, Kei Watanabe, Takashi Kaito, Hidetomi Terai, Koji Tamai, Atushi Tagami, Toshitaka Yoshii, Katsumi Harimaya, Kenichi Kawaguchi, Atsushi KimuraGen Inoue, Atsushi Nakano, Daisuke Sakai, Akihiko Hiyama, Shota Ikegami, Seiji Ohtori, Takeo Furuya, Sumihisa Orita, Shiro Imagama, Kazuyoshi Kobayashi, Katsuhito Kiyasu, Hideki Murakami, Katsuhito Yoshioka, Shoji Seki, Michio Hongo, Kenichiro Kakutani, Takashi Yurube, Yasuchika Aoki, Hiroshi Uei, Yasumitsu Ajiro, Masahiko Takahata, Hirooki Endo, Tetsuya Abe, Kazuyoshi Nakanishi, Kota Watanabe, Eijiro Okada, Naobumi Hosogane, Haruki Funao, Norihiro Isogai, Ken Ishii

Research output: Contribution to journalArticle

Abstract

Purpose: Osteoporotic vertebral fracture (OVF) with nonunion or neurological deficit may be a candidate for surgical treatment. However, some patients do not show improvement as expected. Therefore, we conducted a nationwide multicenter study to determine the predictors for postoperative poor activity of daily living (ADL) in patients with OVF. Methods: We retrospectively reviewed the case histories of 309 patients with OVF who underwent surgery. To determine the factors predicting postoperative poor ADL, uni- and multivariate statistical analyses were performed. Results: The frequency of poor ADL at final follow-up period was 9.1%. In univariate analysis, preoperative neurological deficit (OR, 4.1; 95% CI, 1.8–10.3; P < 0.001), perioperative complication (OR, 3.4; P = 0.006), absence of preoperative bone-modifying agent (BMA) administration (OR, 2.7; P = 0.03), and absence of postoperative recombinant human parathyroid hormone (rPTH) administration (OR, 3.9; P = 0.006) were significantly associated. In multivariate analysis, preoperative neurological deficit (OR, 4.6; P < 0.001), perioperative complication (OR, 3.4; P = 0.01), and absence of postoperative rPTH administration (OR, 3.9; P = 0.02) showed statistical significance. Conclusions: Preoperative neurological deficit, perioperative complication, and absence of postoperative rPTH administration were considered as predictors for postoperative poor ADL in patients with OVF. Neurological deficits and complications are often inevitable factors; therefore, rPTH is an important option for postoperative treatment for OVF. Graphic abstract: These slides can be retrieved under Electronic Supplementary Material.[Figure not available: see fulltext.].

Original languageEnglish
JournalEuropean Spine Journal
DOIs
Publication statusAccepted/In press - 2019 Jan 1

Fingerprint

Osteoporotic Fractures
Activities of Daily Living
Multivariate Analysis
Multicenter Studies
Bone and Bones
human PTH protein
Therapeutics

Keywords

  • Activity of daily living
  • Osteoporotic vertebral fracture
  • Parathyroid hormone

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

The factors related to the poor ADL in the patients with osteoporotic vertebral fracture after instrumentation surgery. / Murata, Kazuma; Matsuoka, Yuji; Nishimura, Hirosuke; Endo, Kenji; Suzuki, Hidekazu; Takamatsu, Taichiro; Sawaji, Yasunobu; Aihara, Takato; Kusakabe, Takuya; Maekawa, Asato; Yamamoto, Kengo; Watanabe, Kei; Kaito, Takashi; Terai, Hidetomi; Tamai, Koji; Tagami, Atushi; Yoshii, Toshitaka; Harimaya, Katsumi; Kawaguchi, Kenichi; Kimura, Atsushi; Inoue, Gen; Nakano, Atsushi; Sakai, Daisuke; Hiyama, Akihiko; Ikegami, Shota; Ohtori, Seiji; Furuya, Takeo; Orita, Sumihisa; Imagama, Shiro; Kobayashi, Kazuyoshi; Kiyasu, Katsuhito; Murakami, Hideki; Yoshioka, Katsuhito; Seki, Shoji; Hongo, Michio; Kakutani, Kenichiro; Yurube, Takashi; Aoki, Yasuchika; Uei, Hiroshi; Ajiro, Yasumitsu; Takahata, Masahiko; Endo, Hirooki; Abe, Tetsuya; Nakanishi, Kazuyoshi; Watanabe, Kota; Okada, Eijiro; Hosogane, Naobumi; Funao, Haruki; Isogai, Norihiro; Ishii, Ken.

In: European Spine Journal, 01.01.2019.

Research output: Contribution to journalArticle

Murata, K, Matsuoka, Y, Nishimura, H, Endo, K, Suzuki, H, Takamatsu, T, Sawaji, Y, Aihara, T, Kusakabe, T, Maekawa, A, Yamamoto, K, Watanabe, K, Kaito, T, Terai, H, Tamai, K, Tagami, A, Yoshii, T, Harimaya, K, Kawaguchi, K, Kimura, A, Inoue, G, Nakano, A, Sakai, D, Hiyama, A, Ikegami, S, Ohtori, S, Furuya, T, Orita, S, Imagama, S, Kobayashi, K, Kiyasu, K, Murakami, H, Yoshioka, K, Seki, S, Hongo, M, Kakutani, K, Yurube, T, Aoki, Y, Uei, H, Ajiro, Y, Takahata, M, Endo, H, Abe, T, Nakanishi, K, Watanabe, K, Okada, E, Hosogane, N, Funao, H, Isogai, N & Ishii, K 2019, 'The factors related to the poor ADL in the patients with osteoporotic vertebral fracture after instrumentation surgery', European Spine Journal. https://doi.org/10.1007/s00586-019-06092-0
Murata, Kazuma ; Matsuoka, Yuji ; Nishimura, Hirosuke ; Endo, Kenji ; Suzuki, Hidekazu ; Takamatsu, Taichiro ; Sawaji, Yasunobu ; Aihara, Takato ; Kusakabe, Takuya ; Maekawa, Asato ; Yamamoto, Kengo ; Watanabe, Kei ; Kaito, Takashi ; Terai, Hidetomi ; Tamai, Koji ; Tagami, Atushi ; Yoshii, Toshitaka ; Harimaya, Katsumi ; Kawaguchi, Kenichi ; Kimura, Atsushi ; Inoue, Gen ; Nakano, Atsushi ; Sakai, Daisuke ; Hiyama, Akihiko ; Ikegami, Shota ; Ohtori, Seiji ; Furuya, Takeo ; Orita, Sumihisa ; Imagama, Shiro ; Kobayashi, Kazuyoshi ; Kiyasu, Katsuhito ; Murakami, Hideki ; Yoshioka, Katsuhito ; Seki, Shoji ; Hongo, Michio ; Kakutani, Kenichiro ; Yurube, Takashi ; Aoki, Yasuchika ; Uei, Hiroshi ; Ajiro, Yasumitsu ; Takahata, Masahiko ; Endo, Hirooki ; Abe, Tetsuya ; Nakanishi, Kazuyoshi ; Watanabe, Kota ; Okada, Eijiro ; Hosogane, Naobumi ; Funao, Haruki ; Isogai, Norihiro ; Ishii, Ken. / The factors related to the poor ADL in the patients with osteoporotic vertebral fracture after instrumentation surgery. In: European Spine Journal. 2019.
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abstract = "Purpose: Osteoporotic vertebral fracture (OVF) with nonunion or neurological deficit may be a candidate for surgical treatment. However, some patients do not show improvement as expected. Therefore, we conducted a nationwide multicenter study to determine the predictors for postoperative poor activity of daily living (ADL) in patients with OVF. Methods: We retrospectively reviewed the case histories of 309 patients with OVF who underwent surgery. To determine the factors predicting postoperative poor ADL, uni- and multivariate statistical analyses were performed. Results: The frequency of poor ADL at final follow-up period was 9.1{\%}. In univariate analysis, preoperative neurological deficit (OR, 4.1; 95{\%} CI, 1.8–10.3; P < 0.001), perioperative complication (OR, 3.4; P = 0.006), absence of preoperative bone-modifying agent (BMA) administration (OR, 2.7; P = 0.03), and absence of postoperative recombinant human parathyroid hormone (rPTH) administration (OR, 3.9; P = 0.006) were significantly associated. In multivariate analysis, preoperative neurological deficit (OR, 4.6; P < 0.001), perioperative complication (OR, 3.4; P = 0.01), and absence of postoperative rPTH administration (OR, 3.9; P = 0.02) showed statistical significance. Conclusions: Preoperative neurological deficit, perioperative complication, and absence of postoperative rPTH administration were considered as predictors for postoperative poor ADL in patients with OVF. Neurological deficits and complications are often inevitable factors; therefore, rPTH is an important option for postoperative treatment for OVF. Graphic abstract: These slides can be retrieved under Electronic Supplementary Material.[Figure not available: see fulltext.].",
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author = "Kazuma Murata and Yuji Matsuoka and Hirosuke Nishimura and Kenji Endo and Hidekazu Suzuki and Taichiro Takamatsu and Yasunobu Sawaji and Takato Aihara and Takuya Kusakabe and Asato Maekawa and Kengo Yamamoto and Kei Watanabe and Takashi Kaito and Hidetomi Terai and Koji Tamai and Atushi Tagami and Toshitaka Yoshii and Katsumi Harimaya and Kenichi Kawaguchi and Atsushi Kimura and Gen Inoue and Atsushi Nakano and Daisuke Sakai and Akihiko Hiyama and Shota Ikegami and Seiji Ohtori and Takeo Furuya and Sumihisa Orita and Shiro Imagama and Kazuyoshi Kobayashi and Katsuhito Kiyasu and Hideki Murakami and Katsuhito Yoshioka and Shoji Seki and Michio Hongo and Kenichiro Kakutani and Takashi Yurube and Yasuchika Aoki and Hiroshi Uei and Yasumitsu Ajiro and Masahiko Takahata and Hirooki Endo and Tetsuya Abe and Kazuyoshi Nakanishi and Kota Watanabe and Eijiro Okada and Naobumi Hosogane and Haruki Funao and Norihiro Isogai and Ken Ishii",
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T1 - The factors related to the poor ADL in the patients with osteoporotic vertebral fracture after instrumentation surgery

AU - Murata, Kazuma

AU - Matsuoka, Yuji

AU - Nishimura, Hirosuke

AU - Endo, Kenji

AU - Suzuki, Hidekazu

AU - Takamatsu, Taichiro

AU - Sawaji, Yasunobu

AU - Aihara, Takato

AU - Kusakabe, Takuya

AU - Maekawa, Asato

AU - Yamamoto, Kengo

AU - Watanabe, Kei

AU - Kaito, Takashi

AU - Terai, Hidetomi

AU - Tamai, Koji

AU - Tagami, Atushi

AU - Yoshii, Toshitaka

AU - Harimaya, Katsumi

AU - Kawaguchi, Kenichi

AU - Kimura, Atsushi

AU - Inoue, Gen

AU - Nakano, Atsushi

AU - Sakai, Daisuke

AU - Hiyama, Akihiko

AU - Ikegami, Shota

AU - Ohtori, Seiji

AU - Furuya, Takeo

AU - Orita, Sumihisa

AU - Imagama, Shiro

AU - Kobayashi, Kazuyoshi

AU - Kiyasu, Katsuhito

AU - Murakami, Hideki

AU - Yoshioka, Katsuhito

AU - Seki, Shoji

AU - Hongo, Michio

AU - Kakutani, Kenichiro

AU - Yurube, Takashi

AU - Aoki, Yasuchika

AU - Uei, Hiroshi

AU - Ajiro, Yasumitsu

AU - Takahata, Masahiko

AU - Endo, Hirooki

AU - Abe, Tetsuya

AU - Nakanishi, Kazuyoshi

AU - Watanabe, Kota

AU - Okada, Eijiro

AU - Hosogane, Naobumi

AU - Funao, Haruki

AU - Isogai, Norihiro

AU - Ishii, Ken

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Purpose: Osteoporotic vertebral fracture (OVF) with nonunion or neurological deficit may be a candidate for surgical treatment. However, some patients do not show improvement as expected. Therefore, we conducted a nationwide multicenter study to determine the predictors for postoperative poor activity of daily living (ADL) in patients with OVF. Methods: We retrospectively reviewed the case histories of 309 patients with OVF who underwent surgery. To determine the factors predicting postoperative poor ADL, uni- and multivariate statistical analyses were performed. Results: The frequency of poor ADL at final follow-up period was 9.1%. In univariate analysis, preoperative neurological deficit (OR, 4.1; 95% CI, 1.8–10.3; P < 0.001), perioperative complication (OR, 3.4; P = 0.006), absence of preoperative bone-modifying agent (BMA) administration (OR, 2.7; P = 0.03), and absence of postoperative recombinant human parathyroid hormone (rPTH) administration (OR, 3.9; P = 0.006) were significantly associated. In multivariate analysis, preoperative neurological deficit (OR, 4.6; P < 0.001), perioperative complication (OR, 3.4; P = 0.01), and absence of postoperative rPTH administration (OR, 3.9; P = 0.02) showed statistical significance. Conclusions: Preoperative neurological deficit, perioperative complication, and absence of postoperative rPTH administration were considered as predictors for postoperative poor ADL in patients with OVF. Neurological deficits and complications are often inevitable factors; therefore, rPTH is an important option for postoperative treatment for OVF. Graphic abstract: These slides can be retrieved under Electronic Supplementary Material.[Figure not available: see fulltext.].

AB - Purpose: Osteoporotic vertebral fracture (OVF) with nonunion or neurological deficit may be a candidate for surgical treatment. However, some patients do not show improvement as expected. Therefore, we conducted a nationwide multicenter study to determine the predictors for postoperative poor activity of daily living (ADL) in patients with OVF. Methods: We retrospectively reviewed the case histories of 309 patients with OVF who underwent surgery. To determine the factors predicting postoperative poor ADL, uni- and multivariate statistical analyses were performed. Results: The frequency of poor ADL at final follow-up period was 9.1%. In univariate analysis, preoperative neurological deficit (OR, 4.1; 95% CI, 1.8–10.3; P < 0.001), perioperative complication (OR, 3.4; P = 0.006), absence of preoperative bone-modifying agent (BMA) administration (OR, 2.7; P = 0.03), and absence of postoperative recombinant human parathyroid hormone (rPTH) administration (OR, 3.9; P = 0.006) were significantly associated. In multivariate analysis, preoperative neurological deficit (OR, 4.6; P < 0.001), perioperative complication (OR, 3.4; P = 0.01), and absence of postoperative rPTH administration (OR, 3.9; P = 0.02) showed statistical significance. Conclusions: Preoperative neurological deficit, perioperative complication, and absence of postoperative rPTH administration were considered as predictors for postoperative poor ADL in patients with OVF. Neurological deficits and complications are often inevitable factors; therefore, rPTH is an important option for postoperative treatment for OVF. Graphic abstract: These slides can be retrieved under Electronic Supplementary Material.[Figure not available: see fulltext.].

KW - Activity of daily living

KW - Osteoporotic vertebral fracture

KW - Parathyroid hormone

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DO - 10.1007/s00586-019-06092-0

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JO - European Spine Journal

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SN - 0940-6719

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