The feasibility of reduced-intensity allogeneic hematopoietic stem cell transplantation from a related donor with HLA one-antigen with or without one-allele mismatch

Kunihisa Nakai; Shin Mineishi; Masahiro Kami; Yoshinobu Konda; Ryuji Tanosaki; Yoichi Takaue

The feasibility of reduced-intensity allogeneic hematopoietic stem cell transplantation from a related donor with HLA one-antigen with or without one-allele mismatch

Kunihisa Nakai, Shin Mineishi, Masahiro Kami, Yoshinobu Konda, Ryuji Tanosaki, Yoichi Takaue

Research output: Contribution to journal › Article › peer-review

Abstract

It is still unclear whether reduced-intensity stem cell transplantation (RIST) from an HLA-mismatched related donor is feasible for hematologic malignancies. In the current study on the use of antithymocyte globulin (ATG) in 13 patients, we focused on this issue by evaluating regimenrelated toxicities, engraftment, graft-versus-host disease (GVHD), infection, and overall survival. Our results suggest that this procedure may be acceptable for patients without a matched related donor.

Original language	English
Pages (from-to)	115-117
Number of pages	3
Journal	Haematologica
Volume	88
Issue number	1
Publication status	Published - 2003 Feb 1
Externally published	Yes

Keywords

Engraftment
GVHD
Mismatched reduced-intensity stem cell transplantation

ASJC Scopus subject areas

Hematology

Cite this

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abstract = "It is still unclear whether reduced-intensity stem cell transplantation (RIST) from an HLA-mismatched related donor is feasible for hematologic malignancies. In the current study on the use of antithymocyte globulin (ATG) in 13 patients, we focused on this issue by evaluating regimenrelated toxicities, engraftment, graft-versus-host disease (GVHD), infection, and overall survival. Our results suggest that this procedure may be acceptable for patients without a matched related donor.",

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AU - Kami, Masahiro

AU - Konda, Yoshinobu

AU - Tanosaki, Ryuji

AU - Takaue, Yoichi

PY - 2003/2/1

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N2 - It is still unclear whether reduced-intensity stem cell transplantation (RIST) from an HLA-mismatched related donor is feasible for hematologic malignancies. In the current study on the use of antithymocyte globulin (ATG) in 13 patients, we focused on this issue by evaluating regimenrelated toxicities, engraftment, graft-versus-host disease (GVHD), infection, and overall survival. Our results suggest that this procedure may be acceptable for patients without a matched related donor.

AB - It is still unclear whether reduced-intensity stem cell transplantation (RIST) from an HLA-mismatched related donor is feasible for hematologic malignancies. In the current study on the use of antithymocyte globulin (ATG) in 13 patients, we focused on this issue by evaluating regimenrelated toxicities, engraftment, graft-versus-host disease (GVHD), infection, and overall survival. Our results suggest that this procedure may be acceptable for patients without a matched related donor.

KW - Engraftment

KW - GVHD

KW - Mismatched reduced-intensity stem cell transplantation

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The feasibility of reduced-intensity allogeneic hematopoietic stem cell transplantation from a related donor with HLA one-antigen with or without one-allele mismatch

Abstract

Keywords

ASJC Scopus subject areas

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