The feasibility of reduced-intensity allogeneic hematopoietic stem cell transplantation from a related donor with HLA one-antigen with or without one-allele mismatch

Kunihisa Nakai, Shin Mineishi, Masahiro Kami, Yoshinobu Konda, Ryuji Tanosaki, Yoichi Takaue

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

It is still unclear whether reduced-intensity stem cell transplantation (RIST) from an HLA-mismatched related donor is feasible for hematologic malignancies. In the current study on the use of antithymocyte globulin (ATG) in 13 patients, we focused on this issue by evaluating regimenrelated toxicities, engraftment, graft-versus-host disease (GVHD), infection, and overall survival. Our results suggest that this procedure may be acceptable for patients without a matched related donor.

Original languageEnglish
Pages (from-to)115-117
Number of pages3
JournalHaematologica
Volume88
Issue number1
Publication statusPublished - 2003 Feb 1
Externally publishedYes

Keywords

  • Engraftment
  • GVHD
  • Mismatched reduced-intensity stem cell transplantation

ASJC Scopus subject areas

  • Hematology

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