The fifth exon of the myelin proteolipid protein-coding gene is not utilized in the brain of jimpy mutant mice

Akira Moriguchi, Kazuhiro Ikenaka, Teiichi Furuichi, Hideyuki Okano, Yasuno Iwasaki, Katsuhiko Mikoshiba

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The jimpy mouse, an X-linked recessive dysmyelinating and demyelinating mutant, has been shown to contain abnormal myelin proteolipid protein (PLP) mRNA. To understand the molecular basis of the mutation, we analyzed the structure of PLP mRNA by an RNase-mapping procedure, using the probes specific to each exon of the mouse PLP gene. We found that the fifth exon of the PLP gene is not utilized in the jimpy.

Original languageEnglish
Pages (from-to)333-337
Number of pages5
JournalGene
Volume55
Issue number2-3
DOIs
Publication statusPublished - 1987
Externally publishedYes

Keywords

  • Pelizaeus-Merzbacher disease
  • RNase A and T1 mapping
  • X-linked
  • myelin deficiency
  • oligodendrocytes
  • phage vectors
  • recombinant DNA

ASJC Scopus subject areas

  • Genetics

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