The first case of cutaneous mucormycosis caused by Rhizopus azygosporus

Atsushi Fujimoto, K. Nagao, K. Tanaka, J. Yamagami, S. I. Udagawa, M. Sugiura

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

A rapidly enlarging leg ulcer appeared in a 54-year-old woman with systemic lupus erythematosus receiving aggressive immunosuppressive therapy. Skin biopsy revealed proliferation of hyphae in the midst of a neutrophilic abscess. Culture yielded Rhizopus azygosporus. As no organ involvement was detected by thorough examination, the patient was diagnosed as having primary cutaneous mucormycosis. Although intravenous amphotericin B therapy seemed to be very effective, it had to be discontinued due to nephrotoxicity. She unfortunately died of subsequent disseminated fungal infection and cerebral infarction in which the primary cause could not be determined. Minimum inhibitory concentrations of several antifungal drugs to the isolate were examined and amphotericin B proved to be the only agent that may potentially reach the effective plasma concentration. This is the first case report of cutaneous mucormycosis caused by R. azygosporus.

Original languageEnglish
Pages (from-to)428-430
Number of pages3
JournalBritish Journal of Dermatology
Volume153
Issue number2
DOIs
Publication statusPublished - 2005 Aug 1
Externally publishedYes

Keywords

  • Amphotericin B
  • Cutaneous
  • Leg ulcer
  • Minimum inhibitory concentration
  • Mucormycosis
  • Rhizopus azygosporus

ASJC Scopus subject areas

  • Dermatology

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