The first synthesis of both enantiomers of [α-2H]phenylacetic acid in high enantiomeric excess

K. Matoishi, S. Hanzawa, H. Kakidani, M. Suzuki, Takeshi Sugai, H. Ohta

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Arylmalonate decarboxylase (EC. 4. 1. 1. 76) catalysed decarboxylation followed by enantioface-differentiating protonation of [α-2H]- and [α-1H]phenylmalonic acid in 1H2O and 2H2O respectively, gave highly enantiomerically enriched (R)- and (S)-[α-2H]phenylacetic acid in quantitative yields.

Original languageEnglish
Pages (from-to)1519-1520
Number of pages2
JournalChemical Communications
Issue number16
Publication statusPublished - 2000 Aug 21

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Enantiomers
Protonation
Acids
phenylmalonic acid
phenylacetic acid
Decarboxylation
malonate decarboxylase

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Matoishi, K., Hanzawa, S., Kakidani, H., Suzuki, M., Sugai, T., & Ohta, H. (2000). The first synthesis of both enantiomers of [α-2H]phenylacetic acid in high enantiomeric excess. Chemical Communications, (16), 1519-1520.

The first synthesis of both enantiomers of [α-2H]phenylacetic acid in high enantiomeric excess. / Matoishi, K.; Hanzawa, S.; Kakidani, H.; Suzuki, M.; Sugai, Takeshi; Ohta, H.

In: Chemical Communications, No. 16, 21.08.2000, p. 1519-1520.

Research output: Contribution to journalArticle

Matoishi, K, Hanzawa, S, Kakidani, H, Suzuki, M, Sugai, T & Ohta, H 2000, 'The first synthesis of both enantiomers of [α-2H]phenylacetic acid in high enantiomeric excess', Chemical Communications, no. 16, pp. 1519-1520.
Matoishi, K. ; Hanzawa, S. ; Kakidani, H. ; Suzuki, M. ; Sugai, Takeshi ; Ohta, H. / The first synthesis of both enantiomers of [α-2H]phenylacetic acid in high enantiomeric excess. In: Chemical Communications. 2000 ; No. 16. pp. 1519-1520.
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