TY - JOUR
T1 - The function of the Drosophila argos gene product in the development of embryonic chordotonal organs
AU - Okabe, Masataka
AU - Sawamoto, Kazunobu
AU - Okano, Hideyuki
N1 - Funding Information:
The authors express their thanks to Drs. Shingo Yoshikawa, Keita Koizumi, Tadashi Uemura, Teiichi Tanimura, and Katsuhiko Mikoshiba for enlightening discussions, to Drs. Akira Chiba, Mika Takahashi for technical instructions, to Drs. Yuh Nung Jan, Shigeo Hayashi, and Miyuki Yamamoto for their valuable comments on the manuscript, and to the entire staff of the Okano Laboratory and that of the Hotta Laboratory for their encouragement. We are also grateful to the Bloomington Stock Center for providing the strains used in this study. This work was supported by grants to H.O. from the Ministry of Education, Science, and Culture of Japan and the TARA Okano project.
PY - 1996/4/10
Y1 - 1996/4/10
N2 - We characterized the embryonic expression pattern and mutant phenotypes of the Drosophila gene argos, which encodes a secreted protein with an epidermal growth factor motif. The argos null mutation caused an increase in chordotonal (Ch) organs in both the thoracic and the abdominal segments, whereas overexpression of the argos gene resulted in a decrease in these organs. We showed that the argos transcripts are expressed transiently in the cells surrounding the Ch organ precursor and that the gene rhomboid (rho), which is involved in the regulation of the number of Ch organs, acts epistatically to argos in this event. Our findings suggest that argos plays a role in Ch organ precursor formation and regulates the final number of Ch organs.
AB - We characterized the embryonic expression pattern and mutant phenotypes of the Drosophila gene argos, which encodes a secreted protein with an epidermal growth factor motif. The argos null mutation caused an increase in chordotonal (Ch) organs in both the thoracic and the abdominal segments, whereas overexpression of the argos gene resulted in a decrease in these organs. We showed that the argos transcripts are expressed transiently in the cells surrounding the Ch organ precursor and that the gene rhomboid (rho), which is involved in the regulation of the number of Ch organs, acts epistatically to argos in this event. Our findings suggest that argos plays a role in Ch organ precursor formation and regulates the final number of Ch organs.
UR - http://www.scopus.com/inward/record.url?scp=0029932730&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029932730&partnerID=8YFLogxK
U2 - 10.1006/dbio.1996.0093
DO - 10.1006/dbio.1996.0093
M3 - Article
C2 - 8608867
AN - SCOPUS:0029932730
SN - 0012-1606
VL - 175
SP - 37
EP - 49
JO - Developmental Biology
JF - Developmental Biology
IS - 1
ER -