The function of the Drosophila argos gene product in the development of embryonic chordotonal organs

Masataka Okabe, Kazunobu Sawamoto, Hideyuki Okano

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

We characterized the embryonic expression pattern and mutant phenotypes of the Drosophila gene argos, which encodes a secreted protein with an epidermal growth factor motif. The argos null mutation caused an increase in chordotonal (Ch) organs in both the thoracic and the abdominal segments, whereas overexpression of the argos gene resulted in a decrease in these organs. We showed that the argos transcripts are expressed transiently in the cells surrounding the Ch organ precursor and that the gene rhomboid (rho), which is involved in the regulation of the number of Ch organs, acts epistatically to argos in this event. Our findings suggest that argos plays a role in Ch organ precursor formation and regulates the final number of Ch organs.

Original languageEnglish
Pages (from-to)37-49
Number of pages13
JournalDevelopmental Biology
Volume175
Issue number1
DOIs
Publication statusPublished - 1996 Apr 10
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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