The fundamental and clinical studies on cefpiramide in pediatric field

K. Jozaki, S. Iwata, Y. Iwasaki

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Abstract

Fundamental and clinical studies on cefpiramide (CPM), a new semisynthetic cephalosporin, were made and the following results were obtained. The antibacterial activities of CPM against clinical isolates were almost similar to those of conventional cephems except for Pseudomonas aeruginosa. The antibacterial activity of CPM against P. aeruginosa was excellent and superior to those of the others. Ten or twenty mg/kg of CPM was given intravenously as one shot to 11 cases. The mean serum levels of CPM reached 231 μg/ml at 15 minutes, 119 μg/ml at 30 minutes, 88 μg/ml at 1 hour, 65 μg/ml at 2 hours and 33 μg/ml at 6 hours after administration at a single dose of 10 mg/kg, respectively with the half-life of 3.42 hours. In case of 20 mg/kg, the mean serum levels reached 306 μg/ml at 15 minutes, 245 μg/ml at 30 minutes, 160 μg/ml at 1 hour, 118 μg/ml at 2 hours and 66 μg/ml at 6 hours respectively after administration with the half-life of 5.20 hours. CPM was given intravenously to 12 patients with various bacterial infections. The clinical effects were excellent in 5 cases, good in 6 cases and poor in 1 case and the effective rate was 92%. No side effect was observed in any of the cases.

Original languageEnglish
Pages (from-to)2195-2200
Number of pages6
JournalJapanese Journal of Antibiotics
Volume36
Issue number8
Publication statusPublished - 1983

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ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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