The G1 restriction point as critical regulator of neocortical neuronogenesis

V. S. Caviness, Takao Takahashi, R. S. Nowakowski

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Neuronogenesis in the pseudostratified ventricular epithelium is the initial process in a succession of histogenetic events which give rise to the laminate neocortex. Here we review experimental findings in mouse which support the thesis that the restriction point of the G1 phase of the cell cycle is the critical point of regulation of the overall neuronogenetic process. The neuronogenetic interval in mouse spans 6 days. In the course of these 6 days the founder population and its progeny execute 11 cell cycles. With each successive cycle there is an increase in the fraction of postmitotic cells which leaves the cycle (the Q fraction) and also an increase in the length of the cell cycle due to an increase in the length of the G1 phase of the cycle. Q corresponds to the probability that postmitotic cells will exit the cycle at the restriction point of the G1 phase of the cell cycle. Q increases non-linearly, but the rate of change of Q with cycle (i.e., the first derivative) over the course of the neuronogenetic interval is a constant, k, which appears to be set principally by cell internal mechanisms which are species specific. Q also seems to be modulated, but at low amplitude, by a balance of mitogenic and antimitogenic influences acting from without the cell. We suggest that intracellular signal transduction systems control a general advance of Q during development and thereby determine the general developmental plan (i.e., cell number and laminar composition) of the neocortex and that external mitogens and anti-mitogens modulate this advance regionally and temporally and thereby produce regional modifications of the general plan.

Original languageEnglish
Pages (from-to)497-506
Number of pages10
JournalNeurochemical Research
Volume24
Issue number4
Publication statusPublished - 1999

Fingerprint

G1 Phase Cell Cycle Checkpoints
Cell Cycle
Cells
Neocortex
Mitogens
Signal transduction
G1 Phase
Laminates
Signal Transduction
Epithelium
Cell Count
Derivatives
Control systems
Chemical analysis
Population

Keywords

  • Cell cycle
  • G1 restriction
  • Neuronogenesis

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry

Cite this

The G1 restriction point as critical regulator of neocortical neuronogenesis. / Caviness, V. S.; Takahashi, Takao; Nowakowski, R. S.

In: Neurochemical Research, Vol. 24, No. 4, 1999, p. 497-506.

Research output: Contribution to journalArticle

Caviness, V. S. ; Takahashi, Takao ; Nowakowski, R. S. / The G1 restriction point as critical regulator of neocortical neuronogenesis. In: Neurochemical Research. 1999 ; Vol. 24, No. 4. pp. 497-506.
@article{d300926b2fa4435cbab2f9be907d1f80,
title = "The G1 restriction point as critical regulator of neocortical neuronogenesis",
abstract = "Neuronogenesis in the pseudostratified ventricular epithelium is the initial process in a succession of histogenetic events which give rise to the laminate neocortex. Here we review experimental findings in mouse which support the thesis that the restriction point of the G1 phase of the cell cycle is the critical point of regulation of the overall neuronogenetic process. The neuronogenetic interval in mouse spans 6 days. In the course of these 6 days the founder population and its progeny execute 11 cell cycles. With each successive cycle there is an increase in the fraction of postmitotic cells which leaves the cycle (the Q fraction) and also an increase in the length of the cell cycle due to an increase in the length of the G1 phase of the cycle. Q corresponds to the probability that postmitotic cells will exit the cycle at the restriction point of the G1 phase of the cell cycle. Q increases non-linearly, but the rate of change of Q with cycle (i.e., the first derivative) over the course of the neuronogenetic interval is a constant, k, which appears to be set principally by cell internal mechanisms which are species specific. Q also seems to be modulated, but at low amplitude, by a balance of mitogenic and antimitogenic influences acting from without the cell. We suggest that intracellular signal transduction systems control a general advance of Q during development and thereby determine the general developmental plan (i.e., cell number and laminar composition) of the neocortex and that external mitogens and anti-mitogens modulate this advance regionally and temporally and thereby produce regional modifications of the general plan.",
keywords = "Cell cycle, G1 restriction, Neuronogenesis",
author = "Caviness, {V. S.} and Takao Takahashi and Nowakowski, {R. S.}",
year = "1999",
language = "English",
volume = "24",
pages = "497--506",
journal = "Neurochemical Research",
issn = "0364-3190",
publisher = "Springer New York",
number = "4",

}

TY - JOUR

T1 - The G1 restriction point as critical regulator of neocortical neuronogenesis

AU - Caviness, V. S.

AU - Takahashi, Takao

AU - Nowakowski, R. S.

PY - 1999

Y1 - 1999

N2 - Neuronogenesis in the pseudostratified ventricular epithelium is the initial process in a succession of histogenetic events which give rise to the laminate neocortex. Here we review experimental findings in mouse which support the thesis that the restriction point of the G1 phase of the cell cycle is the critical point of regulation of the overall neuronogenetic process. The neuronogenetic interval in mouse spans 6 days. In the course of these 6 days the founder population and its progeny execute 11 cell cycles. With each successive cycle there is an increase in the fraction of postmitotic cells which leaves the cycle (the Q fraction) and also an increase in the length of the cell cycle due to an increase in the length of the G1 phase of the cycle. Q corresponds to the probability that postmitotic cells will exit the cycle at the restriction point of the G1 phase of the cell cycle. Q increases non-linearly, but the rate of change of Q with cycle (i.e., the first derivative) over the course of the neuronogenetic interval is a constant, k, which appears to be set principally by cell internal mechanisms which are species specific. Q also seems to be modulated, but at low amplitude, by a balance of mitogenic and antimitogenic influences acting from without the cell. We suggest that intracellular signal transduction systems control a general advance of Q during development and thereby determine the general developmental plan (i.e., cell number and laminar composition) of the neocortex and that external mitogens and anti-mitogens modulate this advance regionally and temporally and thereby produce regional modifications of the general plan.

AB - Neuronogenesis in the pseudostratified ventricular epithelium is the initial process in a succession of histogenetic events which give rise to the laminate neocortex. Here we review experimental findings in mouse which support the thesis that the restriction point of the G1 phase of the cell cycle is the critical point of regulation of the overall neuronogenetic process. The neuronogenetic interval in mouse spans 6 days. In the course of these 6 days the founder population and its progeny execute 11 cell cycles. With each successive cycle there is an increase in the fraction of postmitotic cells which leaves the cycle (the Q fraction) and also an increase in the length of the cell cycle due to an increase in the length of the G1 phase of the cycle. Q corresponds to the probability that postmitotic cells will exit the cycle at the restriction point of the G1 phase of the cell cycle. Q increases non-linearly, but the rate of change of Q with cycle (i.e., the first derivative) over the course of the neuronogenetic interval is a constant, k, which appears to be set principally by cell internal mechanisms which are species specific. Q also seems to be modulated, but at low amplitude, by a balance of mitogenic and antimitogenic influences acting from without the cell. We suggest that intracellular signal transduction systems control a general advance of Q during development and thereby determine the general developmental plan (i.e., cell number and laminar composition) of the neocortex and that external mitogens and anti-mitogens modulate this advance regionally and temporally and thereby produce regional modifications of the general plan.

KW - Cell cycle

KW - G1 restriction

KW - Neuronogenesis

UR - http://www.scopus.com/inward/record.url?scp=0344958835&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0344958835&partnerID=8YFLogxK

M3 - Article

C2 - 10227682

AN - SCOPUS:0344958835

VL - 24

SP - 497

EP - 506

JO - Neurochemical Research

JF - Neurochemical Research

SN - 0364-3190

IS - 4

ER -