The genetic and epigenetic basis of distinct melanoma types

Junna Oba, Scott E. Woodman

Research output: Contribution to journalReview articlepeer-review

Abstract

Melanoma represents the deadliest skin cancer. Recent therapeutic developments, including targeted and immune therapies have revolutionized clinical management and improved patient outcome. This progress was achieved by rigorous molecular and functional studies followed by robust clinical trials. The identification of key genomic alterations and gene expression profiles have propelled the understanding of distinct characteristics within melanoma subtypes. The aim of this review is to summarize and highlight the main genetic and epigenetic findings of melanomas and highlight their pathological and therapeutic importance.

Original languageEnglish
Pages (from-to)925-939
Number of pages15
JournalJournal of Dermatology
Volume48
Issue number7
DOIs
Publication statusPublished - 2021 Jul

Keywords

  • epithelial-to-mesenchymal transition
  • gene expression
  • genomic alteration
  • melanoma subtypes
  • phenotypic switching

ASJC Scopus subject areas

  • Dermatology

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