The green and effective oxidation of alcohols to carboxylic acids with molecular oxygen via biocatalytic reaction

Jun ichiro Hirano, Kenji Miyamoto, Hiromichi Ohta

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

A clean and effective alcohol oxidizing system using three enzymes has been developed. Regeneration of NAD+ by NADH oxidase with molecular oxygen enabled to oxidize alcohols to carboxylic acids in good yield under mild conditions (25 °C, 1 atm).

Original languageEnglish
Pages (from-to)1217-1219
Number of pages3
JournalTetrahedron Letters
Volume49
Issue number7
DOIs
Publication statusPublished - 2008 Feb 11

Fingerprint

Molecular oxygen
Carboxylic Acids
Alcohols
Oxygen
Oxidation
NAD
Regeneration
Enzymes
NADH oxidase

Keywords

  • Alcohol oxidation
  • Biocatalyst
  • Green chemistry
  • Molecular oxygen
  • Regeneration of cofactor

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

The green and effective oxidation of alcohols to carboxylic acids with molecular oxygen via biocatalytic reaction. / Hirano, Jun ichiro; Miyamoto, Kenji; Ohta, Hiromichi.

In: Tetrahedron Letters, Vol. 49, No. 7, 11.02.2008, p. 1217-1219.

Research output: Contribution to journalArticle

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