The green and effective oxidation of alcohols to carboxylic acids with molecular oxygen via biocatalytic reaction

Jun ichiro Hirano; Kenji Miyamoto; Hiromichi Ohta

doi:10.1016/j.tetlet.2007.12.032

The green and effective oxidation of alcohols to carboxylic acids with molecular oxygen via biocatalytic reaction

Jun ichiro Hirano, Kenji Miyamoto, Hiromichi Ohta

Department of Biosciences and Informatics

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

A clean and effective alcohol oxidizing system using three enzymes has been developed. Regeneration of NAD⁺ by NADH oxidase with molecular oxygen enabled to oxidize alcohols to carboxylic acids in good yield under mild conditions (25 °C, 1 atm).

Original language	English
Pages (from-to)	1217-1219
Number of pages	3
Journal	Tetrahedron Letters
Volume	49
Issue number	7
DOIs	https://doi.org/10.1016/j.tetlet.2007.12.032
Publication status	Published - 2008 Feb 11

Keywords

Alcohol oxidation
Biocatalyst
Green chemistry
Molecular oxygen
Regeneration of cofactor

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2007.12.032

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title = "The green and effective oxidation of alcohols to carboxylic acids with molecular oxygen via biocatalytic reaction",

abstract = "A clean and effective alcohol oxidizing system using three enzymes has been developed. Regeneration of NAD+ by NADH oxidase with molecular oxygen enabled to oxidize alcohols to carboxylic acids in good yield under mild conditions (25 °C, 1 atm).",

keywords = "Alcohol oxidation, Biocatalyst, Green chemistry, Molecular oxygen, Regeneration of cofactor",

author = "Hirano, {Jun ichiro} and Kenji Miyamoto and Hiromichi Ohta",

note = "Funding Information: This research was partially supported by the Ministry of Education, Culture, Sports, Science and Technology, Grant-in-Aid for the 21st century COE Program entitled {\textquoteleft}Understanding and Control of Life{\textquoteright}s Function via Systems Biology{\textquoteright}, Keio University. ",

year = "2008",

month = feb,

day = "11",

doi = "10.1016/j.tetlet.2007.12.032",

language = "English",

volume = "49",

pages = "1217--1219",

journal = "Tetrahedron Letters",

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T1 - The green and effective oxidation of alcohols to carboxylic acids with molecular oxygen via biocatalytic reaction

AU - Hirano, Jun ichiro

AU - Miyamoto, Kenji

AU - Ohta, Hiromichi

N1 - Funding Information: This research was partially supported by the Ministry of Education, Culture, Sports, Science and Technology, Grant-in-Aid for the 21st century COE Program entitled ‘Understanding and Control of Life’s Function via Systems Biology’, Keio University.

PY - 2008/2/11

Y1 - 2008/2/11

N2 - A clean and effective alcohol oxidizing system using three enzymes has been developed. Regeneration of NAD+ by NADH oxidase with molecular oxygen enabled to oxidize alcohols to carboxylic acids in good yield under mild conditions (25 °C, 1 atm).

AB - A clean and effective alcohol oxidizing system using three enzymes has been developed. Regeneration of NAD+ by NADH oxidase with molecular oxygen enabled to oxidize alcohols to carboxylic acids in good yield under mild conditions (25 °C, 1 atm).

KW - Alcohol oxidation

KW - Biocatalyst

KW - Green chemistry

KW - Molecular oxygen

KW - Regeneration of cofactor

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DO - 10.1016/j.tetlet.2007.12.032

M3 - Article

AN - SCOPUS:38349076961

SN - 0040-4039

VL - 49

SP - 1217

EP - 1219

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 7

ER -

The green and effective oxidation of alcohols to carboxylic acids with molecular oxygen via biocatalytic reaction

Abstract

Keywords

ASJC Scopus subject areas

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