The healing process of gastric artificial ulcers after endoscopic submucosal dissection

Naomi Kakushima, Naohisa Yahagi, Mitsuhiro Fujishiro, Mikitaka Iguchi, Masashi Oka, Katsuya Kobayashi, Takuhei Hashimoto, Masao Omata

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

Background: Due to the remarkable progress of endoscopic resection techniques, endoscopic submucosal dissection (ESD) has been widely performed for larger mucosal tumors that would result in large artificial ulcers. The healing process of peptic ulcers has been previously studied in detail; however, no precise investigation for artificial ulcers after ESD has been reported. To confirm the validity of the treatment from the aspect of wound healing, we aimed to clarify the healing process of large gastric artificial ulcers after ESD. Methods: Seventy patients with gastric mucosal tumors treated by ESD were enrolled. The size, location and time of scar formation of the ulcers were reviewed using endoscopic pictures taken from the same view and angle. Follow-up endoscopy was performed at 1, 4, 8 and 12 weeks after ESD. For postoperative medication, all patients received normal doses of proton pump inhibitors and sucralfate for 8 weeks. Results: The average size of the resected specimen was 34.7 mm (20-90 mm). Irrespective of ulcer size and location, all of the cases healed up to scarring stages within 8 weeks. Conclusions: Gastric artificial ulcers after ESD healed within 8 weeks regardless of size and location using normal doses of medication as peptic ulcers. The fact that even giant ulcers after ESD heal within 8 weeks could be helpful information for candidates for ESD and for postoperative management of patients after ESD.

Original languageEnglish
Pages (from-to)327-331
Number of pages5
JournalDigestive Endoscopy
Volume16
Issue number4
DOIs
Publication statusPublished - 2004 Oct 1
Externally publishedYes

Keywords

  • Artificial ulcer
  • Endoscopic resection
  • Endoscopic submucosal dissection

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology

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  • Cite this

    Kakushima, N., Yahagi, N., Fujishiro, M., Iguchi, M., Oka, M., Kobayashi, K., Hashimoto, T., & Omata, M. (2004). The healing process of gastric artificial ulcers after endoscopic submucosal dissection. Digestive Endoscopy, 16(4), 327-331. https://doi.org/10.1111/j.1443-1661.2004.00413.x