The human immunodeficiency virus-reverse transcriptase inhibition activity of novel pyridine/pyridinium-type fullerene derivatives

Takumi Yasuno, Tomoyuki Ohe, Kyoko Takahashi, Shigeo Nakamura, Tadahiko Mashino

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12 Citations (Scopus)

Abstract

Abstract In the present study, we describe the synthesis of a novel set of pyridine/pyridinium-type fullerene derivatives. The products were assessed for human immunodeficiency virus-reverse transcriptase inhibition activities. All novel fullerene derivatives showed potent human immunodeficiency virus-reverse transcriptase inhibition without cytotoxicity.

Original languageEnglish
Article number22776
Pages (from-to)3226-3229
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume25
Issue number16
DOIs
Publication statusPublished - 2015 Jul 3

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Fullerenes
HIV Reverse Transcriptase
Derivatives
Cytotoxicity
pyridine

Keywords

  • Abbreviations ART antiretroviral therapy
  • HIV human immunodeficiency virus
  • HIV-RT human immunodeficiency virus-reverse transcriptase
  • PMB p-methoxybenzyl

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Molecular Biology
  • Molecular Medicine
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

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abstract = "Abstract In the present study, we describe the synthesis of a novel set of pyridine/pyridinium-type fullerene derivatives. The products were assessed for human immunodeficiency virus-reverse transcriptase inhibition activities. All novel fullerene derivatives showed potent human immunodeficiency virus-reverse transcriptase inhibition without cytotoxicity.",
keywords = "Abbreviations ART antiretroviral therapy, HIV human immunodeficiency virus, HIV-RT human immunodeficiency virus-reverse transcriptase, PMB p-methoxybenzyl",
author = "Takumi Yasuno and Tomoyuki Ohe and Kyoko Takahashi and Shigeo Nakamura and Tadahiko Mashino",
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T1 - The human immunodeficiency virus-reverse transcriptase inhibition activity of novel pyridine/pyridinium-type fullerene derivatives

AU - Yasuno, Takumi

AU - Ohe, Tomoyuki

AU - Takahashi, Kyoko

AU - Nakamura, Shigeo

AU - Mashino, Tadahiko

PY - 2015/7/3

Y1 - 2015/7/3

N2 - Abstract In the present study, we describe the synthesis of a novel set of pyridine/pyridinium-type fullerene derivatives. The products were assessed for human immunodeficiency virus-reverse transcriptase inhibition activities. All novel fullerene derivatives showed potent human immunodeficiency virus-reverse transcriptase inhibition without cytotoxicity.

AB - Abstract In the present study, we describe the synthesis of a novel set of pyridine/pyridinium-type fullerene derivatives. The products were assessed for human immunodeficiency virus-reverse transcriptase inhibition activities. All novel fullerene derivatives showed potent human immunodeficiency virus-reverse transcriptase inhibition without cytotoxicity.

KW - Abbreviations ART antiretroviral therapy

KW - HIV human immunodeficiency virus

KW - HIV-RT human immunodeficiency virus-reverse transcriptase

KW - PMB p-methoxybenzyl

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DO - 10.1016/j.bmcl.2015.05.086

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