The IASLC lung cancer staging project: Background data and proposals for the classification of lung cancer with separate tumor nodules in the forthcoming eighth edition of the TNM classification for lung cancer

Frank C. Detterbeck, Vanessa Bolejack, Douglas A. Arenberg, John Crowley, Jessica S. Donington, Wilbur A. Franklin, Nicolas Girard, Edith M. Marom, Peter J. Mazzone, Andrew G. Nicholson, Valerie W. Rusch, Lynn T. Tanoue, William D. Travis, Hisao Asamura, Ramón Rami-Porta

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Introduction: Separate tumor nodules with the same histologic appearance occur in the lungs in a small proportion of patients with primary lung cancer. This article addresses how such tumors canbe classified to informthe eightheditionof the anatomic classification of lung cancer. Separate tumor nodules should be distinguished from second primary lung cancer, multifocal ground glass/lepidic tumors, and pneumonic-type lung cancer, which are addressed in separate analyses. Methods: Survival of patients with separate tumor nodules in the International Association for the Study of Lung Cancer database were analyzed. This was compared with a systematic literature review. Results: Survival of clinically staged patients decreased according to the location of the separate tumor nodule relative to the index tumor (same lobe > same side > other side) in N0 and N-any cohorts (all M0 except possible other-side nodules). However, there was also a decrease in the proportion of patients resected; among only surgically resected or among nonresected patients no survival differences were noted. There were no survival differences between patients with same-lobe nodules and those with other T3 tumors, between patients with sameside nodules and those with T4 tumors, and patients with other-side nodules and those with other M1a tumors. The data correlated with those identified in a literature review. Conclusions: Tumors with same-lobe separate tumor nodules (with the same histologic appearance) are recommended to be classified as T3, same-side nodules as T4, and other-side nodules as M1a. Thus, there is no recommended change between the seventh and eighth edition of the TNM classification of lung cancer.

Original languageEnglish
Pages (from-to)681-692
Number of pages12
JournalJournal of Thoracic Oncology
Volume11
Issue number5
DOIs
Publication statusPublished - 2016

Fingerprint

Neoplasm Staging
Lung Neoplasms
Neoplasms
Survival
Second Primary Neoplasms
Glass
Databases

Keywords

  • Lung cancer
  • Lung cancer staging
  • Multiple tumors
  • Non-small cell lung cancer
  • TNM classification

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine

Cite this

The IASLC lung cancer staging project : Background data and proposals for the classification of lung cancer with separate tumor nodules in the forthcoming eighth edition of the TNM classification for lung cancer. / Detterbeck, Frank C.; Bolejack, Vanessa; Arenberg, Douglas A.; Crowley, John; Donington, Jessica S.; Franklin, Wilbur A.; Girard, Nicolas; Marom, Edith M.; Mazzone, Peter J.; Nicholson, Andrew G.; Rusch, Valerie W.; Tanoue, Lynn T.; Travis, William D.; Asamura, Hisao; Rami-Porta, Ramón.

In: Journal of Thoracic Oncology, Vol. 11, No. 5, 2016, p. 681-692.

Research output: Contribution to journalArticle

Detterbeck, FC, Bolejack, V, Arenberg, DA, Crowley, J, Donington, JS, Franklin, WA, Girard, N, Marom, EM, Mazzone, PJ, Nicholson, AG, Rusch, VW, Tanoue, LT, Travis, WD, Asamura, H & Rami-Porta, R 2016, 'The IASLC lung cancer staging project: Background data and proposals for the classification of lung cancer with separate tumor nodules in the forthcoming eighth edition of the TNM classification for lung cancer', Journal of Thoracic Oncology, vol. 11, no. 5, pp. 681-692. https://doi.org/10.1016/j.jtho.2015.12.114
Detterbeck, Frank C. ; Bolejack, Vanessa ; Arenberg, Douglas A. ; Crowley, John ; Donington, Jessica S. ; Franklin, Wilbur A. ; Girard, Nicolas ; Marom, Edith M. ; Mazzone, Peter J. ; Nicholson, Andrew G. ; Rusch, Valerie W. ; Tanoue, Lynn T. ; Travis, William D. ; Asamura, Hisao ; Rami-Porta, Ramón. / The IASLC lung cancer staging project : Background data and proposals for the classification of lung cancer with separate tumor nodules in the forthcoming eighth edition of the TNM classification for lung cancer. In: Journal of Thoracic Oncology. 2016 ; Vol. 11, No. 5. pp. 681-692.
@article{508454de41d744b3ba67d17dcbbd2080,
title = "The IASLC lung cancer staging project: Background data and proposals for the classification of lung cancer with separate tumor nodules in the forthcoming eighth edition of the TNM classification for lung cancer",
abstract = "Introduction: Separate tumor nodules with the same histologic appearance occur in the lungs in a small proportion of patients with primary lung cancer. This article addresses how such tumors canbe classified to informthe eightheditionof the anatomic classification of lung cancer. Separate tumor nodules should be distinguished from second primary lung cancer, multifocal ground glass/lepidic tumors, and pneumonic-type lung cancer, which are addressed in separate analyses. Methods: Survival of patients with separate tumor nodules in the International Association for the Study of Lung Cancer database were analyzed. This was compared with a systematic literature review. Results: Survival of clinically staged patients decreased according to the location of the separate tumor nodule relative to the index tumor (same lobe > same side > other side) in N0 and N-any cohorts (all M0 except possible other-side nodules). However, there was also a decrease in the proportion of patients resected; among only surgically resected or among nonresected patients no survival differences were noted. There were no survival differences between patients with same-lobe nodules and those with other T3 tumors, between patients with sameside nodules and those with T4 tumors, and patients with other-side nodules and those with other M1a tumors. The data correlated with those identified in a literature review. Conclusions: Tumors with same-lobe separate tumor nodules (with the same histologic appearance) are recommended to be classified as T3, same-side nodules as T4, and other-side nodules as M1a. Thus, there is no recommended change between the seventh and eighth edition of the TNM classification of lung cancer.",
keywords = "Lung cancer, Lung cancer staging, Multiple tumors, Non-small cell lung cancer, TNM classification",
author = "Detterbeck, {Frank C.} and Vanessa Bolejack and Arenberg, {Douglas A.} and John Crowley and Donington, {Jessica S.} and Franklin, {Wilbur A.} and Nicolas Girard and Marom, {Edith M.} and Mazzone, {Peter J.} and Nicholson, {Andrew G.} and Rusch, {Valerie W.} and Tanoue, {Lynn T.} and Travis, {William D.} and Hisao Asamura and Ram{\'o}n Rami-Porta",
year = "2016",
doi = "10.1016/j.jtho.2015.12.114",
language = "English",
volume = "11",
pages = "681--692",
journal = "Journal of Thoracic Oncology",
issn = "1556-0864",
publisher = "International Association for the Study of Lung Cancer",
number = "5",

}

TY - JOUR

T1 - The IASLC lung cancer staging project

T2 - Background data and proposals for the classification of lung cancer with separate tumor nodules in the forthcoming eighth edition of the TNM classification for lung cancer

AU - Detterbeck, Frank C.

AU - Bolejack, Vanessa

AU - Arenberg, Douglas A.

AU - Crowley, John

AU - Donington, Jessica S.

AU - Franklin, Wilbur A.

AU - Girard, Nicolas

AU - Marom, Edith M.

AU - Mazzone, Peter J.

AU - Nicholson, Andrew G.

AU - Rusch, Valerie W.

AU - Tanoue, Lynn T.

AU - Travis, William D.

AU - Asamura, Hisao

AU - Rami-Porta, Ramón

PY - 2016

Y1 - 2016

N2 - Introduction: Separate tumor nodules with the same histologic appearance occur in the lungs in a small proportion of patients with primary lung cancer. This article addresses how such tumors canbe classified to informthe eightheditionof the anatomic classification of lung cancer. Separate tumor nodules should be distinguished from second primary lung cancer, multifocal ground glass/lepidic tumors, and pneumonic-type lung cancer, which are addressed in separate analyses. Methods: Survival of patients with separate tumor nodules in the International Association for the Study of Lung Cancer database were analyzed. This was compared with a systematic literature review. Results: Survival of clinically staged patients decreased according to the location of the separate tumor nodule relative to the index tumor (same lobe > same side > other side) in N0 and N-any cohorts (all M0 except possible other-side nodules). However, there was also a decrease in the proportion of patients resected; among only surgically resected or among nonresected patients no survival differences were noted. There were no survival differences between patients with same-lobe nodules and those with other T3 tumors, between patients with sameside nodules and those with T4 tumors, and patients with other-side nodules and those with other M1a tumors. The data correlated with those identified in a literature review. Conclusions: Tumors with same-lobe separate tumor nodules (with the same histologic appearance) are recommended to be classified as T3, same-side nodules as T4, and other-side nodules as M1a. Thus, there is no recommended change between the seventh and eighth edition of the TNM classification of lung cancer.

AB - Introduction: Separate tumor nodules with the same histologic appearance occur in the lungs in a small proportion of patients with primary lung cancer. This article addresses how such tumors canbe classified to informthe eightheditionof the anatomic classification of lung cancer. Separate tumor nodules should be distinguished from second primary lung cancer, multifocal ground glass/lepidic tumors, and pneumonic-type lung cancer, which are addressed in separate analyses. Methods: Survival of patients with separate tumor nodules in the International Association for the Study of Lung Cancer database were analyzed. This was compared with a systematic literature review. Results: Survival of clinically staged patients decreased according to the location of the separate tumor nodule relative to the index tumor (same lobe > same side > other side) in N0 and N-any cohorts (all M0 except possible other-side nodules). However, there was also a decrease in the proportion of patients resected; among only surgically resected or among nonresected patients no survival differences were noted. There were no survival differences between patients with same-lobe nodules and those with other T3 tumors, between patients with sameside nodules and those with T4 tumors, and patients with other-side nodules and those with other M1a tumors. The data correlated with those identified in a literature review. Conclusions: Tumors with same-lobe separate tumor nodules (with the same histologic appearance) are recommended to be classified as T3, same-side nodules as T4, and other-side nodules as M1a. Thus, there is no recommended change between the seventh and eighth edition of the TNM classification of lung cancer.

KW - Lung cancer

KW - Lung cancer staging

KW - Multiple tumors

KW - Non-small cell lung cancer

KW - TNM classification

UR - http://www.scopus.com/inward/record.url?scp=84969765414&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84969765414&partnerID=8YFLogxK

U2 - 10.1016/j.jtho.2015.12.114

DO - 10.1016/j.jtho.2015.12.114

M3 - Article

C2 - 26940530

AN - SCOPUS:84969765414

VL - 11

SP - 681

EP - 692

JO - Journal of Thoracic Oncology

JF - Journal of Thoracic Oncology

SN - 1556-0864

IS - 5

ER -