The identification of two germ-line mutations in the human breast cancer resistance protein gene that result in the expression of a low/non-functional protein

Medicine & Life Sciences

• human ABCG2 protein 100%
• Germ-Line Mutation 60%
• Genes 21%
• Proteins 19%
• Irinotecan 13%
• ATP Binding Cassette Transporter, Subfamily G, Member 2 9%
• Drug Resistance 5%
• Single Nucleotide Polymorphism 4%
• Complementary DNA 4%
• Pharmacokinetics 4%
• Alleles 4%
• Breast Neoplasms 3%
• Gene Expression 3%
• Mutation 3%

Chemical Compounds

• Mutation 45%
• SN-38 43%
• Resistance 33%
• Protein 22%
• Pharmacokinetics 10%
• Amount 5%
• Surface 4%