The impact of body temperature abnormalities on the disease severity and outcome in patients with severe sepsis: An analysis from a multicenter, prospective survey of severe sepsis

Shigeki Kushimoto, Satoshi Gando, Daizoh Saitoh, Toshihiko Mayumi, Hiroshi Ogura, Seitaro Fujishima, Tsunetoshi Araki, Hiroto Ikeda, Joji Kotani, Yasuo Miki, Shin ichiro Shiraishi, Koichiro Suzuki, Yasushi Suzuki, Naoshi Takeyama, Kiyotsugu Takuma, Ryosuke Tsuruta, Yoshihiro Yamaguchi, Norio Yamashita, Naoki Aikawa

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Abstract

Introduction: Abnormal body temperatures (Tb) are frequently seen in patients with severe sepsis. However, the relationship between Tb abnormalities and the severity of disease is not clear. This study investigated the impact of Tb on disease severity and outcomes in patients with severe sepsis. Methods: We enrolled 624 patients with severe sepsis and grouped them into 6 categories according to their Tb at the time of enrollment. The temperature categories (≤35.5°C, 35.6-36.5°C, 36.6-37.5°C, 37.6-38.5°C, 38.6-39.5°C, ≥39.6°C) were based on the temperature data of the Acute Physiology and Chronic Health Evaluation II (APACHE II) scoring. We compared patient characteristics, physiological data, and mortality between groups. Results: Patients with Tb of ≤36.5°C had significantly worse sequential organ failure assessment (SOFA) scores when compared with patients with Tb >37.5°C on the day of enrollment. Scores for APACHE II were also higher in patients with Tb ≤35.5°C when compared with patients with Tb >36.5°C. The 28-day and hospital mortality was significantly higher in patients with Tb ≤36.5°C. The difference in mortality rate was especially noticeable when patients with Tb ≤35.5°C were compared with patients who had Tb of >36.5°C. Although mortality did not relate to Tb ranges of ≥37.6°C as compared to reference range of 36.6-37.5°C, relative risk for 28-day mortality was significantly greater in patients with 35.6-36.5°C and ≤35.5°C (odds ratio; 2.032, 3.096, respectively). When patients were divided into groups based on the presence (≤36.5°C, n = 160) or absence (>36.5°C, n = 464) of hypothermia, disseminated intravascular coagulation (DIC) as well as SOFA and APACHE II scores were significantly higher in patients with hypothermia. Patients with hypothermia had significantly higher 28-day and hospital mortality rates than those without hypothermia (38.1% vs. 17.9% and 49.4% vs. 22.6%, respectively). The presence of hypothermia was an independent predictor of 28-day mortality, and the differences between patients with and without hypothermia were observed irrespective of the presence of septic shock. Conclusions: In patients with severe sepsis, hypothermia (Tb ≤36.5°C) was associated with increased mortality and organ failure, irrespective of the presence of septic shock.Trial registration: UMIN-CTR ID UMIN000008195.

Original languageEnglish
Article numberR271
JournalCritical Care
Volume17
Issue number6
DOIs
Publication statusPublished - 2013 Nov 13

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Body Temperature
Sepsis
Hypothermia
Mortality
APACHE
Surveys and Questionnaires
Septic Shock
Hospital Mortality
Organ Dysfunction Scores
Temperature
Disseminated Intravascular Coagulation

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Medicine(all)

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The impact of body temperature abnormalities on the disease severity and outcome in patients with severe sepsis : An analysis from a multicenter, prospective survey of severe sepsis. / Kushimoto, Shigeki; Gando, Satoshi; Saitoh, Daizoh; Mayumi, Toshihiko; Ogura, Hiroshi; Fujishima, Seitaro; Araki, Tsunetoshi; Ikeda, Hiroto; Kotani, Joji; Miki, Yasuo; Shiraishi, Shin ichiro; Suzuki, Koichiro; Suzuki, Yasushi; Takeyama, Naoshi; Takuma, Kiyotsugu; Tsuruta, Ryosuke; Yamaguchi, Yoshihiro; Yamashita, Norio; Aikawa, Naoki.

In: Critical Care, Vol. 17, No. 6, R271, 13.11.2013.

Research output: Contribution to journalArticle

Kushimoto, S, Gando, S, Saitoh, D, Mayumi, T, Ogura, H, Fujishima, S, Araki, T, Ikeda, H, Kotani, J, Miki, Y, Shiraishi, SI, Suzuki, K, Suzuki, Y, Takeyama, N, Takuma, K, Tsuruta, R, Yamaguchi, Y, Yamashita, N & Aikawa, N 2013, 'The impact of body temperature abnormalities on the disease severity and outcome in patients with severe sepsis: An analysis from a multicenter, prospective survey of severe sepsis', Critical Care, vol. 17, no. 6, R271. https://doi.org/10.1186/cc13106
Kushimoto, Shigeki ; Gando, Satoshi ; Saitoh, Daizoh ; Mayumi, Toshihiko ; Ogura, Hiroshi ; Fujishima, Seitaro ; Araki, Tsunetoshi ; Ikeda, Hiroto ; Kotani, Joji ; Miki, Yasuo ; Shiraishi, Shin ichiro ; Suzuki, Koichiro ; Suzuki, Yasushi ; Takeyama, Naoshi ; Takuma, Kiyotsugu ; Tsuruta, Ryosuke ; Yamaguchi, Yoshihiro ; Yamashita, Norio ; Aikawa, Naoki. / The impact of body temperature abnormalities on the disease severity and outcome in patients with severe sepsis : An analysis from a multicenter, prospective survey of severe sepsis. In: Critical Care. 2013 ; Vol. 17, No. 6.
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T1 - The impact of body temperature abnormalities on the disease severity and outcome in patients with severe sepsis

T2 - An analysis from a multicenter, prospective survey of severe sepsis

AU - Kushimoto, Shigeki

AU - Gando, Satoshi

AU - Saitoh, Daizoh

AU - Mayumi, Toshihiko

AU - Ogura, Hiroshi

AU - Fujishima, Seitaro

AU - Araki, Tsunetoshi

AU - Ikeda, Hiroto

AU - Kotani, Joji

AU - Miki, Yasuo

AU - Shiraishi, Shin ichiro

AU - Suzuki, Koichiro

AU - Suzuki, Yasushi

AU - Takeyama, Naoshi

AU - Takuma, Kiyotsugu

AU - Tsuruta, Ryosuke

AU - Yamaguchi, Yoshihiro

AU - Yamashita, Norio

AU - Aikawa, Naoki

PY - 2013/11/13

Y1 - 2013/11/13

N2 - Introduction: Abnormal body temperatures (Tb) are frequently seen in patients with severe sepsis. However, the relationship between Tb abnormalities and the severity of disease is not clear. This study investigated the impact of Tb on disease severity and outcomes in patients with severe sepsis. Methods: We enrolled 624 patients with severe sepsis and grouped them into 6 categories according to their Tb at the time of enrollment. The temperature categories (≤35.5°C, 35.6-36.5°C, 36.6-37.5°C, 37.6-38.5°C, 38.6-39.5°C, ≥39.6°C) were based on the temperature data of the Acute Physiology and Chronic Health Evaluation II (APACHE II) scoring. We compared patient characteristics, physiological data, and mortality between groups. Results: Patients with Tb of ≤36.5°C had significantly worse sequential organ failure assessment (SOFA) scores when compared with patients with Tb >37.5°C on the day of enrollment. Scores for APACHE II were also higher in patients with Tb ≤35.5°C when compared with patients with Tb >36.5°C. The 28-day and hospital mortality was significantly higher in patients with Tb ≤36.5°C. The difference in mortality rate was especially noticeable when patients with Tb ≤35.5°C were compared with patients who had Tb of >36.5°C. Although mortality did not relate to Tb ranges of ≥37.6°C as compared to reference range of 36.6-37.5°C, relative risk for 28-day mortality was significantly greater in patients with 35.6-36.5°C and ≤35.5°C (odds ratio; 2.032, 3.096, respectively). When patients were divided into groups based on the presence (≤36.5°C, n = 160) or absence (>36.5°C, n = 464) of hypothermia, disseminated intravascular coagulation (DIC) as well as SOFA and APACHE II scores were significantly higher in patients with hypothermia. Patients with hypothermia had significantly higher 28-day and hospital mortality rates than those without hypothermia (38.1% vs. 17.9% and 49.4% vs. 22.6%, respectively). The presence of hypothermia was an independent predictor of 28-day mortality, and the differences between patients with and without hypothermia were observed irrespective of the presence of septic shock. Conclusions: In patients with severe sepsis, hypothermia (Tb ≤36.5°C) was associated with increased mortality and organ failure, irrespective of the presence of septic shock.Trial registration: UMIN-CTR ID UMIN000008195.

AB - Introduction: Abnormal body temperatures (Tb) are frequently seen in patients with severe sepsis. However, the relationship between Tb abnormalities and the severity of disease is not clear. This study investigated the impact of Tb on disease severity and outcomes in patients with severe sepsis. Methods: We enrolled 624 patients with severe sepsis and grouped them into 6 categories according to their Tb at the time of enrollment. The temperature categories (≤35.5°C, 35.6-36.5°C, 36.6-37.5°C, 37.6-38.5°C, 38.6-39.5°C, ≥39.6°C) were based on the temperature data of the Acute Physiology and Chronic Health Evaluation II (APACHE II) scoring. We compared patient characteristics, physiological data, and mortality between groups. Results: Patients with Tb of ≤36.5°C had significantly worse sequential organ failure assessment (SOFA) scores when compared with patients with Tb >37.5°C on the day of enrollment. Scores for APACHE II were also higher in patients with Tb ≤35.5°C when compared with patients with Tb >36.5°C. The 28-day and hospital mortality was significantly higher in patients with Tb ≤36.5°C. The difference in mortality rate was especially noticeable when patients with Tb ≤35.5°C were compared with patients who had Tb of >36.5°C. Although mortality did not relate to Tb ranges of ≥37.6°C as compared to reference range of 36.6-37.5°C, relative risk for 28-day mortality was significantly greater in patients with 35.6-36.5°C and ≤35.5°C (odds ratio; 2.032, 3.096, respectively). When patients were divided into groups based on the presence (≤36.5°C, n = 160) or absence (>36.5°C, n = 464) of hypothermia, disseminated intravascular coagulation (DIC) as well as SOFA and APACHE II scores were significantly higher in patients with hypothermia. Patients with hypothermia had significantly higher 28-day and hospital mortality rates than those without hypothermia (38.1% vs. 17.9% and 49.4% vs. 22.6%, respectively). The presence of hypothermia was an independent predictor of 28-day mortality, and the differences between patients with and without hypothermia were observed irrespective of the presence of septic shock. Conclusions: In patients with severe sepsis, hypothermia (Tb ≤36.5°C) was associated with increased mortality and organ failure, irrespective of the presence of septic shock.Trial registration: UMIN-CTR ID UMIN000008195.

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