The impact of extent of resection and histological subtype on the outcome of adult patients with high-grade gliomas

Shigeru Yamaguchi, Hiroyuki Kobayashi, Shunsuke Terasaka, Nobuaki Ishii, Jun Ikeda, Hiromi Kanno, Hiroshi Nishihara, Shinya Tanaka, Kiyohiro Houkin

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Objective: We reviewed the relationship between extent of resection and survival of patients with high-grade gliomas with special consideration of an oligodendroglial component. Methods: A retrospective review was performed on 160 adult patients with histological diagnosis of high-grade gliomas since 2000. All histological slides were categorized as high-grade astrocytomas or oligodendroglial tumors. Extent of resection was assessed by early post-operative magnetic resonance imaging and classified as complete resection, incomplete resection and biopsy. Measured outcomes were overall survival and progression-free survival. The independent association of extent of resection and survival was analyzed by the multivariate proportional hazard model adjusting for prognostic factors. Results: The lesions were classified as high-grade astrocytomas in 93 patients and high-grade oligodendroglial tumors in 67 patients. In high-grade astrocytomas, the median survival after complete resection (n = 36), incomplete resection (n = 36) and biopsy (n = 21) was 23.4, 15.3 and 12.6 months, respectively. Complete resection was independently associated with increased overall survival (P < 0.001) and progression-free survival (P = 0.002) compared with incomplete resection, while incomplete resection was not associated with survival benefit compared with biopsy by multivariate analysis. On the other hand, in high-grade oligodendroglial tumors, the majority of patients were still alive and there is no significant difference in the survival between complete resection (n = 24) and incomplete resection (n = 33), while even incomplete resection had a significantly longer overall survival (P < 0.001) and progression-free survival (P = 0.006) compared with biopsy (n = 10). Conclusions: Maximal cytoreduction improves the survival of high-grade gliomas, although our data indicated that the impact of extent of resection in high-grade astrocytomas is different from that in high-grade oligodendroglial tumors.

Original languageEnglish
Article numberhys016
Pages (from-to)270-277
Number of pages8
JournalJapanese journal of clinical oncology
Volume42
Issue number4
DOIs
Publication statusPublished - 2012 Apr 1
Externally publishedYes

Fingerprint

Glioma
Survival
Astrocytoma
Disease-Free Survival
Biopsy
Neoplasms
Proportional Hazards Models
Multivariate Analysis
Magnetic Resonance Imaging

Keywords

  • Astrocytoma
  • Malignant glioma
  • Multivariate analyses
  • Oligodendroglioma
  • Survival

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Yamaguchi, S., Kobayashi, H., Terasaka, S., Ishii, N., Ikeda, J., Kanno, H., ... Houkin, K. (2012). The impact of extent of resection and histological subtype on the outcome of adult patients with high-grade gliomas. Japanese journal of clinical oncology, 42(4), 270-277. [hys016]. https://doi.org/10.1093/jjco/hys016

The impact of extent of resection and histological subtype on the outcome of adult patients with high-grade gliomas. / Yamaguchi, Shigeru; Kobayashi, Hiroyuki; Terasaka, Shunsuke; Ishii, Nobuaki; Ikeda, Jun; Kanno, Hiromi; Nishihara, Hiroshi; Tanaka, Shinya; Houkin, Kiyohiro.

In: Japanese journal of clinical oncology, Vol. 42, No. 4, hys016, 01.04.2012, p. 270-277.

Research output: Contribution to journalArticle

Yamaguchi, S, Kobayashi, H, Terasaka, S, Ishii, N, Ikeda, J, Kanno, H, Nishihara, H, Tanaka, S & Houkin, K 2012, 'The impact of extent of resection and histological subtype on the outcome of adult patients with high-grade gliomas', Japanese journal of clinical oncology, vol. 42, no. 4, hys016, pp. 270-277. https://doi.org/10.1093/jjco/hys016
Yamaguchi, Shigeru ; Kobayashi, Hiroyuki ; Terasaka, Shunsuke ; Ishii, Nobuaki ; Ikeda, Jun ; Kanno, Hiromi ; Nishihara, Hiroshi ; Tanaka, Shinya ; Houkin, Kiyohiro. / The impact of extent of resection and histological subtype on the outcome of adult patients with high-grade gliomas. In: Japanese journal of clinical oncology. 2012 ; Vol. 42, No. 4. pp. 270-277.
@article{179ae924a4bc48188eab672f3fca6d31,
title = "The impact of extent of resection and histological subtype on the outcome of adult patients with high-grade gliomas",
abstract = "Objective: We reviewed the relationship between extent of resection and survival of patients with high-grade gliomas with special consideration of an oligodendroglial component. Methods: A retrospective review was performed on 160 adult patients with histological diagnosis of high-grade gliomas since 2000. All histological slides were categorized as high-grade astrocytomas or oligodendroglial tumors. Extent of resection was assessed by early post-operative magnetic resonance imaging and classified as complete resection, incomplete resection and biopsy. Measured outcomes were overall survival and progression-free survival. The independent association of extent of resection and survival was analyzed by the multivariate proportional hazard model adjusting for prognostic factors. Results: The lesions were classified as high-grade astrocytomas in 93 patients and high-grade oligodendroglial tumors in 67 patients. In high-grade astrocytomas, the median survival after complete resection (n = 36), incomplete resection (n = 36) and biopsy (n = 21) was 23.4, 15.3 and 12.6 months, respectively. Complete resection was independently associated with increased overall survival (P < 0.001) and progression-free survival (P = 0.002) compared with incomplete resection, while incomplete resection was not associated with survival benefit compared with biopsy by multivariate analysis. On the other hand, in high-grade oligodendroglial tumors, the majority of patients were still alive and there is no significant difference in the survival between complete resection (n = 24) and incomplete resection (n = 33), while even incomplete resection had a significantly longer overall survival (P < 0.001) and progression-free survival (P = 0.006) compared with biopsy (n = 10). Conclusions: Maximal cytoreduction improves the survival of high-grade gliomas, although our data indicated that the impact of extent of resection in high-grade astrocytomas is different from that in high-grade oligodendroglial tumors.",
keywords = "Astrocytoma, Malignant glioma, Multivariate analyses, Oligodendroglioma, Survival",
author = "Shigeru Yamaguchi and Hiroyuki Kobayashi and Shunsuke Terasaka and Nobuaki Ishii and Jun Ikeda and Hiromi Kanno and Hiroshi Nishihara and Shinya Tanaka and Kiyohiro Houkin",
year = "2012",
month = "4",
day = "1",
doi = "10.1093/jjco/hys016",
language = "English",
volume = "42",
pages = "270--277",
journal = "Japanese Journal of Clinical Oncology",
issn = "0368-2811",
publisher = "Oxford University Press",
number = "4",

}

TY - JOUR

T1 - The impact of extent of resection and histological subtype on the outcome of adult patients with high-grade gliomas

AU - Yamaguchi, Shigeru

AU - Kobayashi, Hiroyuki

AU - Terasaka, Shunsuke

AU - Ishii, Nobuaki

AU - Ikeda, Jun

AU - Kanno, Hiromi

AU - Nishihara, Hiroshi

AU - Tanaka, Shinya

AU - Houkin, Kiyohiro

PY - 2012/4/1

Y1 - 2012/4/1

N2 - Objective: We reviewed the relationship between extent of resection and survival of patients with high-grade gliomas with special consideration of an oligodendroglial component. Methods: A retrospective review was performed on 160 adult patients with histological diagnosis of high-grade gliomas since 2000. All histological slides were categorized as high-grade astrocytomas or oligodendroglial tumors. Extent of resection was assessed by early post-operative magnetic resonance imaging and classified as complete resection, incomplete resection and biopsy. Measured outcomes were overall survival and progression-free survival. The independent association of extent of resection and survival was analyzed by the multivariate proportional hazard model adjusting for prognostic factors. Results: The lesions were classified as high-grade astrocytomas in 93 patients and high-grade oligodendroglial tumors in 67 patients. In high-grade astrocytomas, the median survival after complete resection (n = 36), incomplete resection (n = 36) and biopsy (n = 21) was 23.4, 15.3 and 12.6 months, respectively. Complete resection was independently associated with increased overall survival (P < 0.001) and progression-free survival (P = 0.002) compared with incomplete resection, while incomplete resection was not associated with survival benefit compared with biopsy by multivariate analysis. On the other hand, in high-grade oligodendroglial tumors, the majority of patients were still alive and there is no significant difference in the survival between complete resection (n = 24) and incomplete resection (n = 33), while even incomplete resection had a significantly longer overall survival (P < 0.001) and progression-free survival (P = 0.006) compared with biopsy (n = 10). Conclusions: Maximal cytoreduction improves the survival of high-grade gliomas, although our data indicated that the impact of extent of resection in high-grade astrocytomas is different from that in high-grade oligodendroglial tumors.

AB - Objective: We reviewed the relationship between extent of resection and survival of patients with high-grade gliomas with special consideration of an oligodendroglial component. Methods: A retrospective review was performed on 160 adult patients with histological diagnosis of high-grade gliomas since 2000. All histological slides were categorized as high-grade astrocytomas or oligodendroglial tumors. Extent of resection was assessed by early post-operative magnetic resonance imaging and classified as complete resection, incomplete resection and biopsy. Measured outcomes were overall survival and progression-free survival. The independent association of extent of resection and survival was analyzed by the multivariate proportional hazard model adjusting for prognostic factors. Results: The lesions were classified as high-grade astrocytomas in 93 patients and high-grade oligodendroglial tumors in 67 patients. In high-grade astrocytomas, the median survival after complete resection (n = 36), incomplete resection (n = 36) and biopsy (n = 21) was 23.4, 15.3 and 12.6 months, respectively. Complete resection was independently associated with increased overall survival (P < 0.001) and progression-free survival (P = 0.002) compared with incomplete resection, while incomplete resection was not associated with survival benefit compared with biopsy by multivariate analysis. On the other hand, in high-grade oligodendroglial tumors, the majority of patients were still alive and there is no significant difference in the survival between complete resection (n = 24) and incomplete resection (n = 33), while even incomplete resection had a significantly longer overall survival (P < 0.001) and progression-free survival (P = 0.006) compared with biopsy (n = 10). Conclusions: Maximal cytoreduction improves the survival of high-grade gliomas, although our data indicated that the impact of extent of resection in high-grade astrocytomas is different from that in high-grade oligodendroglial tumors.

KW - Astrocytoma

KW - Malignant glioma

KW - Multivariate analyses

KW - Oligodendroglioma

KW - Survival

UR - http://www.scopus.com/inward/record.url?scp=84859232962&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84859232962&partnerID=8YFLogxK

U2 - 10.1093/jjco/hys016

DO - 10.1093/jjco/hys016

M3 - Article

C2 - 22399670

AN - SCOPUS:84859232962

VL - 42

SP - 270

EP - 277

JO - Japanese Journal of Clinical Oncology

JF - Japanese Journal of Clinical Oncology

SN - 0368-2811

IS - 4

M1 - hys016

ER -