The impact of interfractional anatomical changes on the accumulated dose in carbon ion therapy of pancreatic cancer patients

Antonetta C. Houweling, Kyohei Fukata, Yoshiki Kubota, Hirofumi Shimada, Coen R.N. Rasch, Tatsuya Ohno, Arjan Bel, Astrid Van Der Horst

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background and purpose We evaluated the robustness of carbon ion therapy for pancreatic cancer patients by investigating the impact of interfractional anatomical changes on the accumulated dose when using bony anatomy- and fiducial marker-based position verification. Material and methods Carbon ion treatment plans were created for 9 patients in this retrospective planning study. The planning CT was deformably registered to each daily cone-beam CT (CBCT). The gastrointestinal gas volume visible on each CBCT was copied to these deformed CT images. Subsequently, the fraction doses were calculated by aligning the treatment plan according to a bony anatomy- and a fiducial marker-based registration. We compared the accumulated fraction doses with the planned dose using dose-volume histograms (DVHs) of the internal gross tumour volume (iGTV), internal clinical target volume (iCTV), duodenum, stomach, liver, spinal cord and kidneys. Results iCTV coverage (D98%) was on average reduced from 98.6% as planned to 81.9% and 88.6% for the bony anatomy- and marker-based registrations, respectively. DVHs of the duodenum showed large differences between the planned and accumulated dose. Conclusions Severe reductions in dose coverage of the target due to interfractional anatomical changes were observed in both position verification methods.

Original languageEnglish
Pages (from-to)319-325
Number of pages7
JournalRadiotherapy and Oncology
Volume119
Issue number2
DOIs
Publication statusPublished - 2016 May 1
Externally publishedYes

Fingerprint

Heavy Ion Radiotherapy
Pancreatic Neoplasms
Fiducial Markers
Anatomy
Duodenum
Cone-Beam Computed Tomography
Tumor Burden
Spinal Cord
Stomach
Carbon
Retrospective Studies
Gases
Ions
Kidney
Liver
Therapeutics

Keywords

  • Accumulated dose
  • Anatomical changes
  • Carbon ion therapy
  • Pancreatic cancer
  • Position verification

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

Houweling, A. C., Fukata, K., Kubota, Y., Shimada, H., Rasch, C. R. N., Ohno, T., ... Van Der Horst, A. (2016). The impact of interfractional anatomical changes on the accumulated dose in carbon ion therapy of pancreatic cancer patients. Radiotherapy and Oncology, 119(2), 319-325. https://doi.org/10.1016/j.radonc.2016.03.004

The impact of interfractional anatomical changes on the accumulated dose in carbon ion therapy of pancreatic cancer patients. / Houweling, Antonetta C.; Fukata, Kyohei; Kubota, Yoshiki; Shimada, Hirofumi; Rasch, Coen R.N.; Ohno, Tatsuya; Bel, Arjan; Van Der Horst, Astrid.

In: Radiotherapy and Oncology, Vol. 119, No. 2, 01.05.2016, p. 319-325.

Research output: Contribution to journalArticle

Houweling, AC, Fukata, K, Kubota, Y, Shimada, H, Rasch, CRN, Ohno, T, Bel, A & Van Der Horst, A 2016, 'The impact of interfractional anatomical changes on the accumulated dose in carbon ion therapy of pancreatic cancer patients', Radiotherapy and Oncology, vol. 119, no. 2, pp. 319-325. https://doi.org/10.1016/j.radonc.2016.03.004
Houweling, Antonetta C. ; Fukata, Kyohei ; Kubota, Yoshiki ; Shimada, Hirofumi ; Rasch, Coen R.N. ; Ohno, Tatsuya ; Bel, Arjan ; Van Der Horst, Astrid. / The impact of interfractional anatomical changes on the accumulated dose in carbon ion therapy of pancreatic cancer patients. In: Radiotherapy and Oncology. 2016 ; Vol. 119, No. 2. pp. 319-325.
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