The Impact of Nasal Conjunctivochalasis on Tear Functions and Ocular Surface Findings

Yan Wang, Murat Dogru, Yukihiro Matsumoto, Samantha K. Ward, Igarashi Ayako, Yiqian Hu, Naoko Okada, Yoko Ogawa, Jun Shimazaki, Kazuo Tsubota

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Purpose: To investigate the effect of grade 3 nasal conjunctivochalasis (NCCh) on the tear film inflammation, ocular surface findings, and tear function findings. Design: Prospective, observational case series. Methods: Eleven eyes with Yokoi grade 3 NCCh in which the chalatic conjunctiva occluded the punctum and 18 eyes without NCCh but with central or temporal conjunctivochalasis, or both, and 16 eyes of healthy controls were recruited prospectively. Enzyme-linked immunosorbent assay for inflammatory tear cytokines, tear film break-up time (BUT), Schirmer I test measurements, and fluorescein and rose bengal vital stainings and impression cytologic and brush cytologic analysis for real-time reverse-transcriptase polymerase chain reaction analysis of MUC5AC messenger ribonucleic acid (mRNA) expression were performed. Results: Eyes with grade 3 NCCh had significantly delayed tear clearance. All inflammatory cytokines showed higher values in eyes with grade 3 NCCh compared with the eyes without nasal chalasis with a comparably significant elevation in interleukin-1b and tumor necrosis factor α levels. The mean rose bengal score in eyes with grade 3 NCCh was significantly higher compared with eyes without nasal chalasis and eyes of controls. The mean goblet cell density was significantly lower in eyes with grade 3 NCCh with downregulation of the relative MUC5AC mRNA expression. Conclusions: Inflammation plays an important role in the pathogenesis of conjunctivochalasis and is more pronounced in eyes with nasal chalasis. Pooling of inflammatory cytokines in tears of patients with NCCh associated with delayed tear clearance induces distinct adverse effects that affect the ocular surface health.

Original languageEnglish
JournalAmerican Journal of Ophthalmology
Volume144
Issue number6
DOIs
Publication statusPublished - 2007 Dec

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Tears
Nose
Rose Bengal
Cytokines
RNA
Inflammation
Goblet Cells
Interleukins
Conjunctiva
Reverse Transcriptase Polymerase Chain Reaction
Fluorescein
Real-Time Polymerase Chain Reaction
Down-Regulation
Tumor Necrosis Factor-alpha
Cell Count
Enzyme-Linked Immunosorbent Assay
Staining and Labeling

ASJC Scopus subject areas

  • Ophthalmology

Cite this

The Impact of Nasal Conjunctivochalasis on Tear Functions and Ocular Surface Findings. / Wang, Yan; Dogru, Murat; Matsumoto, Yukihiro; Ward, Samantha K.; Ayako, Igarashi; Hu, Yiqian; Okada, Naoko; Ogawa, Yoko; Shimazaki, Jun; Tsubota, Kazuo.

In: American Journal of Ophthalmology, Vol. 144, No. 6, 12.2007.

Research output: Contribution to journalArticle

Wang, Y, Dogru, M, Matsumoto, Y, Ward, SK, Ayako, I, Hu, Y, Okada, N, Ogawa, Y, Shimazaki, J & Tsubota, K 2007, 'The Impact of Nasal Conjunctivochalasis on Tear Functions and Ocular Surface Findings', American Journal of Ophthalmology, vol. 144, no. 6. https://doi.org/10.1016/j.ajo.2007.07.037
Wang, Yan ; Dogru, Murat ; Matsumoto, Yukihiro ; Ward, Samantha K. ; Ayako, Igarashi ; Hu, Yiqian ; Okada, Naoko ; Ogawa, Yoko ; Shimazaki, Jun ; Tsubota, Kazuo. / The Impact of Nasal Conjunctivochalasis on Tear Functions and Ocular Surface Findings. In: American Journal of Ophthalmology. 2007 ; Vol. 144, No. 6.
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abstract = "Purpose: To investigate the effect of grade 3 nasal conjunctivochalasis (NCCh) on the tear film inflammation, ocular surface findings, and tear function findings. Design: Prospective, observational case series. Methods: Eleven eyes with Yokoi grade 3 NCCh in which the chalatic conjunctiva occluded the punctum and 18 eyes without NCCh but with central or temporal conjunctivochalasis, or both, and 16 eyes of healthy controls were recruited prospectively. Enzyme-linked immunosorbent assay for inflammatory tear cytokines, tear film break-up time (BUT), Schirmer I test measurements, and fluorescein and rose bengal vital stainings and impression cytologic and brush cytologic analysis for real-time reverse-transcriptase polymerase chain reaction analysis of MUC5AC messenger ribonucleic acid (mRNA) expression were performed. Results: Eyes with grade 3 NCCh had significantly delayed tear clearance. All inflammatory cytokines showed higher values in eyes with grade 3 NCCh compared with the eyes without nasal chalasis with a comparably significant elevation in interleukin-1b and tumor necrosis factor α levels. The mean rose bengal score in eyes with grade 3 NCCh was significantly higher compared with eyes without nasal chalasis and eyes of controls. The mean goblet cell density was significantly lower in eyes with grade 3 NCCh with downregulation of the relative MUC5AC mRNA expression. Conclusions: Inflammation plays an important role in the pathogenesis of conjunctivochalasis and is more pronounced in eyes with nasal chalasis. Pooling of inflammatory cytokines in tears of patients with NCCh associated with delayed tear clearance induces distinct adverse effects that affect the ocular surface health.",
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AU - Ayako, Igarashi

AU - Hu, Yiqian

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N2 - Purpose: To investigate the effect of grade 3 nasal conjunctivochalasis (NCCh) on the tear film inflammation, ocular surface findings, and tear function findings. Design: Prospective, observational case series. Methods: Eleven eyes with Yokoi grade 3 NCCh in which the chalatic conjunctiva occluded the punctum and 18 eyes without NCCh but with central or temporal conjunctivochalasis, or both, and 16 eyes of healthy controls were recruited prospectively. Enzyme-linked immunosorbent assay for inflammatory tear cytokines, tear film break-up time (BUT), Schirmer I test measurements, and fluorescein and rose bengal vital stainings and impression cytologic and brush cytologic analysis for real-time reverse-transcriptase polymerase chain reaction analysis of MUC5AC messenger ribonucleic acid (mRNA) expression were performed. Results: Eyes with grade 3 NCCh had significantly delayed tear clearance. All inflammatory cytokines showed higher values in eyes with grade 3 NCCh compared with the eyes without nasal chalasis with a comparably significant elevation in interleukin-1b and tumor necrosis factor α levels. The mean rose bengal score in eyes with grade 3 NCCh was significantly higher compared with eyes without nasal chalasis and eyes of controls. The mean goblet cell density was significantly lower in eyes with grade 3 NCCh with downregulation of the relative MUC5AC mRNA expression. Conclusions: Inflammation plays an important role in the pathogenesis of conjunctivochalasis and is more pronounced in eyes with nasal chalasis. Pooling of inflammatory cytokines in tears of patients with NCCh associated with delayed tear clearance induces distinct adverse effects that affect the ocular surface health.

AB - Purpose: To investigate the effect of grade 3 nasal conjunctivochalasis (NCCh) on the tear film inflammation, ocular surface findings, and tear function findings. Design: Prospective, observational case series. Methods: Eleven eyes with Yokoi grade 3 NCCh in which the chalatic conjunctiva occluded the punctum and 18 eyes without NCCh but with central or temporal conjunctivochalasis, or both, and 16 eyes of healthy controls were recruited prospectively. Enzyme-linked immunosorbent assay for inflammatory tear cytokines, tear film break-up time (BUT), Schirmer I test measurements, and fluorescein and rose bengal vital stainings and impression cytologic and brush cytologic analysis for real-time reverse-transcriptase polymerase chain reaction analysis of MUC5AC messenger ribonucleic acid (mRNA) expression were performed. Results: Eyes with grade 3 NCCh had significantly delayed tear clearance. All inflammatory cytokines showed higher values in eyes with grade 3 NCCh compared with the eyes without nasal chalasis with a comparably significant elevation in interleukin-1b and tumor necrosis factor α levels. The mean rose bengal score in eyes with grade 3 NCCh was significantly higher compared with eyes without nasal chalasis and eyes of controls. The mean goblet cell density was significantly lower in eyes with grade 3 NCCh with downregulation of the relative MUC5AC mRNA expression. Conclusions: Inflammation plays an important role in the pathogenesis of conjunctivochalasis and is more pronounced in eyes with nasal chalasis. Pooling of inflammatory cytokines in tears of patients with NCCh associated with delayed tear clearance induces distinct adverse effects that affect the ocular surface health.

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