TY - JOUR
T1 - The impact of prolactin-raising antipsychotics on bone mineral density in patients with schizophrenia
T2 - Findings from a longitudinal observational cohort
AU - Takahashi, Tatsuichiro
AU - Uchida, Hiroyuki
AU - John, Majnu
AU - Hirano, Jinichi
AU - Watanabe, Koichiro
AU - Mimura, Masaru
AU - Correll, Christoph U.
AU - Kishimoto, Taishiro
PY - 2013/7/1
Y1 - 2013/7/1
N2 - To examine the effect of prolactin-raising antipsychotics on bone mineral density (BMD), data of 164 schizophrenia patients who received ?. 2 dual-energy x-ray absorptiometry scans were analyzed (49.3% men; mean. ±. SD age: 58.5. ±. 11.0. years; duration of treatment: 26.7. ± 13.8. years). Patients were divided into a prolactin-raising antipsychotic (n = 141) or prolactin-sparing (n = 23) group, and time x group interaction was examined using mixed effect model. Although the BMD difference did not reach significance over 3.4. ± 1.6. years, a significant antipsychotic-class vs. time interaction was found (p = 0.011), indicating a negative impact of prolactin-raising antipsychotics on BMD. Large-scale, randomized-controlled data are required to replicate and extend these findings.
AB - To examine the effect of prolactin-raising antipsychotics on bone mineral density (BMD), data of 164 schizophrenia patients who received ?. 2 dual-energy x-ray absorptiometry scans were analyzed (49.3% men; mean. ±. SD age: 58.5. ±. 11.0. years; duration of treatment: 26.7. ± 13.8. years). Patients were divided into a prolactin-raising antipsychotic (n = 141) or prolactin-sparing (n = 23) group, and time x group interaction was examined using mixed effect model. Although the BMD difference did not reach significance over 3.4. ± 1.6. years, a significant antipsychotic-class vs. time interaction was found (p = 0.011), indicating a negative impact of prolactin-raising antipsychotics on BMD. Large-scale, randomized-controlled data are required to replicate and extend these findings.
KW - Antipsychotics
KW - Bone mineral density
KW - Dual-energy x-ray absorptiometry
KW - Prolactin
KW - Schizophrenia
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U2 - 10.1016/j.schres.2013.04.015
DO - 10.1016/j.schres.2013.04.015
M3 - Article
C2 - 23668975
AN - SCOPUS:84879004266
VL - 147
SP - 383
EP - 386
JO - Schizophrenia Research
JF - Schizophrenia Research
SN - 0920-9964
IS - 2-3
ER -