Abstract
To examine the effect of prolactin-raising antipsychotics on bone mineral density (BMD), data of 164 schizophrenia patients who received ?. 2 dual-energy x-ray absorptiometry scans were analyzed (49.3% men; mean. ±. SD age: 58.5. ±. 11.0. years; duration of treatment: 26.7. ± 13.8. years). Patients were divided into a prolactin-raising antipsychotic (n = 141) or prolactin-sparing (n = 23) group, and time x group interaction was examined using mixed effect model. Although the BMD difference did not reach significance over 3.4. ± 1.6. years, a significant antipsychotic-class vs. time interaction was found (p = 0.011), indicating a negative impact of prolactin-raising antipsychotics on BMD. Large-scale, randomized-controlled data are required to replicate and extend these findings.
| Original language | English |
|---|---|
| Pages (from-to) | 383-386 |
| Number of pages | 4 |
| Journal | Schizophrenia Research |
| Volume | 147 |
| Issue number | 2-3 |
| DOIs | |
| Publication status | Published - 2013 Jul |
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Keywords
- Antipsychotics
- Bone mineral density
- Dual-energy x-ray absorptiometry
- Prolactin
- Schizophrenia
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry
Cite this
The impact of prolactin-raising antipsychotics on bone mineral density in patients with schizophrenia : Findings from a longitudinal observational cohort. / Takahashi, Tatsuichiro; Uchida, Hiroyuki; John, Majnu; Hirano, Jinichi; Watanabe, Koichiro; Mimura, Masaru; Correll, Christoph U.; Kishimoto, Taishiro.
In: Schizophrenia Research, Vol. 147, No. 2-3, 07.2013, p. 383-386.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The impact of prolactin-raising antipsychotics on bone mineral density in patients with schizophrenia
T2 - Findings from a longitudinal observational cohort
AU - Takahashi, Tatsuichiro
AU - Uchida, Hiroyuki
AU - John, Majnu
AU - Hirano, Jinichi
AU - Watanabe, Koichiro
AU - Mimura, Masaru
AU - Correll, Christoph U.
AU - Kishimoto, Taishiro
PY - 2013/7
Y1 - 2013/7
N2 - To examine the effect of prolactin-raising antipsychotics on bone mineral density (BMD), data of 164 schizophrenia patients who received ?. 2 dual-energy x-ray absorptiometry scans were analyzed (49.3% men; mean. ±. SD age: 58.5. ±. 11.0. years; duration of treatment: 26.7. ± 13.8. years). Patients were divided into a prolactin-raising antipsychotic (n = 141) or prolactin-sparing (n = 23) group, and time x group interaction was examined using mixed effect model. Although the BMD difference did not reach significance over 3.4. ± 1.6. years, a significant antipsychotic-class vs. time interaction was found (p = 0.011), indicating a negative impact of prolactin-raising antipsychotics on BMD. Large-scale, randomized-controlled data are required to replicate and extend these findings.
AB - To examine the effect of prolactin-raising antipsychotics on bone mineral density (BMD), data of 164 schizophrenia patients who received ?. 2 dual-energy x-ray absorptiometry scans were analyzed (49.3% men; mean. ±. SD age: 58.5. ±. 11.0. years; duration of treatment: 26.7. ± 13.8. years). Patients were divided into a prolactin-raising antipsychotic (n = 141) or prolactin-sparing (n = 23) group, and time x group interaction was examined using mixed effect model. Although the BMD difference did not reach significance over 3.4. ± 1.6. years, a significant antipsychotic-class vs. time interaction was found (p = 0.011), indicating a negative impact of prolactin-raising antipsychotics on BMD. Large-scale, randomized-controlled data are required to replicate and extend these findings.
KW - Antipsychotics
KW - Bone mineral density
KW - Dual-energy x-ray absorptiometry
KW - Prolactin
KW - Schizophrenia
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UR - http://www.scopus.com/inward/citedby.url?scp=84879004266&partnerID=8YFLogxK
U2 - 10.1016/j.schres.2013.04.015
DO - 10.1016/j.schres.2013.04.015
M3 - Article
VL - 147
SP - 383
EP - 386
JO - Schizophrenia Research
JF - Schizophrenia Research
SN - 0920-9964
IS - 2-3
ER -