Abstract
Aims: To test a hypothesis that women with diabetes mellitus (DM) versus those without DM had a significantly higher risk of heart disease (HD), stroke and all-cause mortality than their male counterparts in the U.S. as well as in Japan. Methods: We analyzed two nationally representative datasets, one from the U.S. NHANES III cohort (n = 13,169), and the other from the Japan NIPPON DATA90 cohort (n = 7445). Hazard ratios (HRs) of DM for risk of mortality and sex-DM interaction effect on mortality were analyzed prospectively using Cox's proportional hazards regression models. Results: Patients with DM had significantly higher mortality from HD, stroke and all-cause mortality in the U.S. and in Japan. However, the HRs of DM versus non-DM for HD and all-cause mortality were significantly higher in women compared to men in the U.S. (sex-DM interaction: HR = 1.59, p = 0.01, and 1.24, p = 0.045 for HD and all-cause mortality), but the sex-DM interaction effect was not statistically significant in the Japanese cohort. Discussion: Patients with DM had a significantly higher risk of mortality than those without DM in the U.S. and Japan. However, women with DM versus those without DM had a higher relative risk of HD and all-cause mortality than their counterparts in men in the U.S, but this sex difference by DM status was not observed in the Japanese cohort. Whether the sex-difference effect of DM on HD and all-cause mortality is due to a difference in metabolic disorders between the two populations warrants consideration and further studies.
| Original language | English |
|---|---|
| Journal | Journal of Diabetes and its Complications |
| DOIs | |
| Publication status | Published - 2019 Jan 1 |
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Keywords
- CVD
- Diabetes mellitus
- US-Japan comparison
ASJC Scopus subject areas
- Internal Medicine
- Endocrinology, Diabetes and Metabolism
- Endocrinology
Cite this
The impact of sex on risk of cardiovascular disease and all-cause mortality in adults with or without diabetes mellitus : A comparison between the U.S. and Japan. / Liu, Longjian; Miura, Katsuyuki; Kadota, Aya; Fujiyoshi, Akira; Gracely, Edward J.; Xue, Fuzhong; Liu, Zuolu; Takashima, Naoyuki; Miyagawa, Naoko; Ohkubo, Takayoshi; Arima, Hisatomi; Okayama, Akira; Okamura, Tomonori; Ueshima, Hirotsugu.
In: Journal of Diabetes and its Complications, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The impact of sex on risk of cardiovascular disease and all-cause mortality in adults with or without diabetes mellitus
T2 - A comparison between the U.S. and Japan
AU - Liu, Longjian
AU - Miura, Katsuyuki
AU - Kadota, Aya
AU - Fujiyoshi, Akira
AU - Gracely, Edward J.
AU - Xue, Fuzhong
AU - Liu, Zuolu
AU - Takashima, Naoyuki
AU - Miyagawa, Naoko
AU - Ohkubo, Takayoshi
AU - Arima, Hisatomi
AU - Okayama, Akira
AU - Okamura, Tomonori
AU - Ueshima, Hirotsugu
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Aims: To test a hypothesis that women with diabetes mellitus (DM) versus those without DM had a significantly higher risk of heart disease (HD), stroke and all-cause mortality than their male counterparts in the U.S. as well as in Japan. Methods: We analyzed two nationally representative datasets, one from the U.S. NHANES III cohort (n = 13,169), and the other from the Japan NIPPON DATA90 cohort (n = 7445). Hazard ratios (HRs) of DM for risk of mortality and sex-DM interaction effect on mortality were analyzed prospectively using Cox's proportional hazards regression models. Results: Patients with DM had significantly higher mortality from HD, stroke and all-cause mortality in the U.S. and in Japan. However, the HRs of DM versus non-DM for HD and all-cause mortality were significantly higher in women compared to men in the U.S. (sex-DM interaction: HR = 1.59, p = 0.01, and 1.24, p = 0.045 for HD and all-cause mortality), but the sex-DM interaction effect was not statistically significant in the Japanese cohort. Discussion: Patients with DM had a significantly higher risk of mortality than those without DM in the U.S. and Japan. However, women with DM versus those without DM had a higher relative risk of HD and all-cause mortality than their counterparts in men in the U.S, but this sex difference by DM status was not observed in the Japanese cohort. Whether the sex-difference effect of DM on HD and all-cause mortality is due to a difference in metabolic disorders between the two populations warrants consideration and further studies.
AB - Aims: To test a hypothesis that women with diabetes mellitus (DM) versus those without DM had a significantly higher risk of heart disease (HD), stroke and all-cause mortality than their male counterparts in the U.S. as well as in Japan. Methods: We analyzed two nationally representative datasets, one from the U.S. NHANES III cohort (n = 13,169), and the other from the Japan NIPPON DATA90 cohort (n = 7445). Hazard ratios (HRs) of DM for risk of mortality and sex-DM interaction effect on mortality were analyzed prospectively using Cox's proportional hazards regression models. Results: Patients with DM had significantly higher mortality from HD, stroke and all-cause mortality in the U.S. and in Japan. However, the HRs of DM versus non-DM for HD and all-cause mortality were significantly higher in women compared to men in the U.S. (sex-DM interaction: HR = 1.59, p = 0.01, and 1.24, p = 0.045 for HD and all-cause mortality), but the sex-DM interaction effect was not statistically significant in the Japanese cohort. Discussion: Patients with DM had a significantly higher risk of mortality than those without DM in the U.S. and Japan. However, women with DM versus those without DM had a higher relative risk of HD and all-cause mortality than their counterparts in men in the U.S, but this sex difference by DM status was not observed in the Japanese cohort. Whether the sex-difference effect of DM on HD and all-cause mortality is due to a difference in metabolic disorders between the two populations warrants consideration and further studies.
KW - CVD
KW - Diabetes mellitus
KW - US-Japan comparison
UR - http://www.scopus.com/inward/record.url?scp=85064270202&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85064270202&partnerID=8YFLogxK
U2 - 10.1016/j.jdiacomp.2019.03.008
DO - 10.1016/j.jdiacomp.2019.03.008
M3 - Article
C2 - 31003923
AN - SCOPUS:85064270202
JO - Journal of Diabetes and its Complications
JF - Journal of Diabetes and its Complications
SN - 1056-8727
ER -