The impact on survival of positive intraoperative pleural lavage cytology in patients with non-small-cell lung cancer

Keiju Aokage, Junji Yoshida, Genichiro Ishii, Sotarou Enatsu, Tomoyuki Hishida, Mitsuyo Nishimura, Yutaka Nishiwaki, Kanji Nagai

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Objective: The aim of this study was to analyze intraoperative pleural lavage cytology results in patients with non-small-cell lung cancer and quantify the impact on survival and recurrence. Methods: From August 1992 through November 2006, pleural lavage cytology results before and after lung resection were both available in 2178 patients with non-small-cell lung cancer. We assessed the pre-pleural lavage cytology impact on survival, comparing with 9 factors available before lung resection by multivariate analyses. We also compared the impact with that of pleural dissemination or malignant pleural effusion. For post-pleural lavage cytology, we analyzed its survival impact in relation with 15 clinicopathologic factors, including those available after resection, by multivariate analyses. Results: Pre-pleural lavage cytology proved to be a strong independent prognostic factor, but the 5-year survival rate was 37% in 65 patients without dissemination but with a positive pre-pleural lavage cytology, which was significantly higher than 12% in 86 patients with dissemination. When factors available after resection were combined, post-pleural lavage cytology showed a stronger survival impact than pre-pleural lavage cytology. Post-pleural lavage cytology was also a strong predictor of recurrence. The positive post-pleural lavage cytology group had a marginally, but not significantly, better survival compared with the malignant pleural effusion group. Almost all patients with positive post-pleural lavage cytology relapsed within 5 years. Conclusions: Pre-pleural lavage cytology is of less use in clinical practice. Post-pleural lavage cytology was a very strong independent prognostic factor, and almost all patients with positive post-pleural lavage cytology relapsed within 5 years. We propose that positive post-pleural lavage cytology disease should be classified to pathologic T4 and managed similarly to dissemination.

Original languageEnglish
JournalJournal of Thoracic and Cardiovascular Surgery
Volume139
Issue number5
DOIs
Publication statusPublished - 2010 May
Externally publishedYes

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Therapeutic Irrigation
Non-Small Cell Lung Carcinoma
Cell Biology
Survival
Malignant Pleural Effusion
Multivariate Analysis
Recurrence
Lung

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Pulmonary and Respiratory Medicine

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The impact on survival of positive intraoperative pleural lavage cytology in patients with non-small-cell lung cancer. / Aokage, Keiju; Yoshida, Junji; Ishii, Genichiro; Enatsu, Sotarou; Hishida, Tomoyuki; Nishimura, Mitsuyo; Nishiwaki, Yutaka; Nagai, Kanji.

In: Journal of Thoracic and Cardiovascular Surgery, Vol. 139, No. 5, 05.2010.

Research output: Contribution to journalArticle

Aokage, Keiju ; Yoshida, Junji ; Ishii, Genichiro ; Enatsu, Sotarou ; Hishida, Tomoyuki ; Nishimura, Mitsuyo ; Nishiwaki, Yutaka ; Nagai, Kanji. / The impact on survival of positive intraoperative pleural lavage cytology in patients with non-small-cell lung cancer. In: Journal of Thoracic and Cardiovascular Surgery. 2010 ; Vol. 139, No. 5.
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abstract = "Objective: The aim of this study was to analyze intraoperative pleural lavage cytology results in patients with non-small-cell lung cancer and quantify the impact on survival and recurrence. Methods: From August 1992 through November 2006, pleural lavage cytology results before and after lung resection were both available in 2178 patients with non-small-cell lung cancer. We assessed the pre-pleural lavage cytology impact on survival, comparing with 9 factors available before lung resection by multivariate analyses. We also compared the impact with that of pleural dissemination or malignant pleural effusion. For post-pleural lavage cytology, we analyzed its survival impact in relation with 15 clinicopathologic factors, including those available after resection, by multivariate analyses. Results: Pre-pleural lavage cytology proved to be a strong independent prognostic factor, but the 5-year survival rate was 37{\%} in 65 patients without dissemination but with a positive pre-pleural lavage cytology, which was significantly higher than 12{\%} in 86 patients with dissemination. When factors available after resection were combined, post-pleural lavage cytology showed a stronger survival impact than pre-pleural lavage cytology. Post-pleural lavage cytology was also a strong predictor of recurrence. The positive post-pleural lavage cytology group had a marginally, but not significantly, better survival compared with the malignant pleural effusion group. Almost all patients with positive post-pleural lavage cytology relapsed within 5 years. Conclusions: Pre-pleural lavage cytology is of less use in clinical practice. Post-pleural lavage cytology was a very strong independent prognostic factor, and almost all patients with positive post-pleural lavage cytology relapsed within 5 years. We propose that positive post-pleural lavage cytology disease should be classified to pathologic T4 and managed similarly to dissemination.",
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AU - Hishida, Tomoyuki

AU - Nishimura, Mitsuyo

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AU - Nagai, Kanji

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AB - Objective: The aim of this study was to analyze intraoperative pleural lavage cytology results in patients with non-small-cell lung cancer and quantify the impact on survival and recurrence. Methods: From August 1992 through November 2006, pleural lavage cytology results before and after lung resection were both available in 2178 patients with non-small-cell lung cancer. We assessed the pre-pleural lavage cytology impact on survival, comparing with 9 factors available before lung resection by multivariate analyses. We also compared the impact with that of pleural dissemination or malignant pleural effusion. For post-pleural lavage cytology, we analyzed its survival impact in relation with 15 clinicopathologic factors, including those available after resection, by multivariate analyses. Results: Pre-pleural lavage cytology proved to be a strong independent prognostic factor, but the 5-year survival rate was 37% in 65 patients without dissemination but with a positive pre-pleural lavage cytology, which was significantly higher than 12% in 86 patients with dissemination. When factors available after resection were combined, post-pleural lavage cytology showed a stronger survival impact than pre-pleural lavage cytology. Post-pleural lavage cytology was also a strong predictor of recurrence. The positive post-pleural lavage cytology group had a marginally, but not significantly, better survival compared with the malignant pleural effusion group. Almost all patients with positive post-pleural lavage cytology relapsed within 5 years. Conclusions: Pre-pleural lavage cytology is of less use in clinical practice. Post-pleural lavage cytology was a very strong independent prognostic factor, and almost all patients with positive post-pleural lavage cytology relapsed within 5 years. We propose that positive post-pleural lavage cytology disease should be classified to pathologic T4 and managed similarly to dissemination.

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