The importance of para-aortic lymph nodes in sentinel lymph node mapping for endometrial cancer by using hysteroscopic radio-isotope tracer injection combined with subserosal dye injection: Prospective study

Fumio Kataoka, Nobuyuki Susumu, Wataru Yamagami, Michiko Kuwahata, Aya Takigawa, Hiroyuki Nomura, Hiroya Takeuchi, Tadaki Nakahara, Kaori Kameyama, Daisuke Aoki

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Objective The objective of this study is to evaluate the detection rate and diagnostic accuracy of sentinel lymph node (SN) mapping using hysteroscopic sub-endometrial injection of 99m-Technetium labeled phytate (Radio-isotope; RI method) and subserosal Indocyanine green (ICG) injection (Dye method) in patients with endometrial cancer. Methods From April 2009 to December 2012, prospective evaluation of 57 Japanese endometrial cancer patients undergoing SN mapping using RI method combined with Dye method was done. To combine RI method or no was determined by a status of RI supply of the tracer injection day. As for 32 cases, both (RI + Dye) methods were used and 23 cases were performed only in Dye method. The primary endpoint was estimation of sensitivity and negative predictive value (NPV) of SN, and analysis of the distribution of SNs with metastasis. Results At least one SN was detected in 100% and average number of detected SNs was 6.0 in RI + Dye method. Sensitivity and NPV were 100%, 100%, respectively. From results of SN mapping, 62.8% of SNs were present in pelvic and 37.1% in para-aortic lymph nodes (PAN). Total 56.3% of lymph nodes with metastasis were present in pelvic and 43.8% in PAN, and the distribution has no difference with SN mapping results (P = 0.602). Among 13 cases with metastatic SNs, 76.9% cases showed metastasis in PAN. Conclusions This SN mapping procedure for endometrial cancer patients revealed high detection rate, sensitivity, NPV, and also indicated the importance of the SN exploration in PAN area.

Original languageEnglish
Pages (from-to)400-404
Number of pages5
JournalGynecologic Oncology
Issue number3
Publication statusPublished - 2016 Mar 1



  • Endometrial cancer
  • Hysteroscopic
  • Para-aortic lymph node
  • Sentinel lymph node

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology

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