The incidence of pediatric invasive Haemophilus influenzae and pneumococcal disease in Chiba prefecture, Japan before and after the introduction of conjugate vaccines

Naruhiko Ishiwada, Haruka Hishiki, Koo Nagasawa, Sachiko Naito, Yasunori Sato, Bin Chang, Yuko Sasaki, Kouji Kimura, Makoto Ohnishi, Keigo Shibayama

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The Haemophilus influenzae type b (Hib) vaccine and the heptavalent pneumococcal conjugate vaccine (PCV7) were introduced in Japan in 2008 and 2010, respectively. In 2011, immunization with these two vaccines was encouraged throughout Japan through a governmental program. Children treated in Chiba prefecture for culture-proven invasive H. influenzae disease (IHiD) and invasive Streptococcus pneumoniae disease (IPD) were identified in a prefectural surveillance study from 2008 to 2013. The incidence rate ratio (IRR) and its confidence interval (CI) were calculated to compare the 3 years before and after governmental financial support for vaccination. The average number of IHiD and IPD cases among children <5 years of age in 2011-2013 decreased 84% (IRR: 0.16, 95% CI: 0.09-0.26, p < 0.0001) and 51% (IRR: 0.49, 95% CI: 0.37-0.63, p < 0.0001) compared with those occurring in 2008-2010. The most common non-PCV7 serotype encountered in 2011 and 2013 was 19A. After governmental subsidization of Hib and PCV7 vaccination, IHiD and IPD decreased in Chiba prefecture, Japan. Continuous surveillance is necessary to determine the effectiveness of these two vaccines and for detection of emerging invasive serotypes.

Original languageEnglish
Pages (from-to)5425-5431
Number of pages7
JournalVaccine
Volume32
Issue number42
DOIs
Publication statusPublished - 2014

Keywords

  • Children
  • Haemophilus influenzae
  • Invasive disease
  • Japan
  • Streptococcus pneumoniae

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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