The induction of Treg cells by gut-indigenous Clostridium

Yuji Nagano, Kikuji Itoh, Kenya Honda

Research output: Contribution to journalReview article

66 Citations (Scopus)

Abstract

Foxp3+ CD4+ cells are prominent immune regulatory T (Treg) cells that are most abundant in the intestine. Recent studies have suggested that intestinal Treg cells consist of thymically and extrathymically developed cells that have unique characteristics. A fraction of intestinal Treg cells express T cell receptors that recognize antigens that are derived from the gut microbiota. The presence of the gut microbiota, particularly the Clostridium species, affects the development and function of Treg cells. These intestinal bacteria-induced Treg cells are likely to play a role in the tolerance toward the gut microbiota. These recent advances provide new insight into how T cells are educated in the intestine to maintain homeostasis with the gut microbiota.

Original languageEnglish
Pages (from-to)392-397
Number of pages6
JournalCurrent Opinion in Immunology
Volume24
Issue number4
DOIs
Publication statusPublished - 2012 Aug 1
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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