TY - JOUR
T1 - The influence of aminotransferase levels on liver stiffness assessed by Acoustic Radiation Force Impulse Elastography
T2 - A retrospective multicentre study
AU - Bota, Simona
AU - Sporea, Ioan
AU - Peck-Radosavljevic, Markus
AU - Sirli, Roxana
AU - Tanaka, Hironori
AU - Iijima, Hiroko
AU - Saito, Hidetsugu
AU - Ebinuma, Hirotoshi
AU - Lupsor, Monica
AU - Badea, Radu
AU - Fierbinteanu-Braticevici, Carmen
AU - Petrisor, Ana
AU - Friedrich-Rust, Mireen
AU - Sarrazin, Christoph
AU - Takahashi, Hirokazu
AU - Ono, Naofumi
AU - Piscaglia, Fabio
AU - Marinelli, Sara
AU - D'Onofrio, Mirko
AU - Gallotti, Anna
AU - Salzl, Petra
AU - Popescu, Alina
AU - Danila, Mirela
PY - 2013/9
Y1 - 2013/9
N2 - Background: Acoustic Radiation Force Impulse Elastography is a new method for non-invasive evaluation of liver fibrosis. Aim: To evaluate the impact of elevated alanine aminotransferase levels on liver stiffness assessment by Acoustic Radiation Force Impulse Elastography. Methods: A multicentre retrospective study including 1242 patients with chronic liver disease, who underwent liver biopsy and Acoustic Radiation Force Impulse. Transient Elastography was also performed in 512 patients. Results: The best Acoustic Radiation Force Impulse cut-off for predicting significant fibrosis was 1.29. m/s in cases with normal alanine aminotransferase levels and 1.44. m/s in patients with alanine aminotransferase levels. >. 5× the upper limit of normal. The best cut-off for predicting liver cirrhosis were 1.59 and 1.75. m/s, respectively.Acoustic Radiation Force Impulse cut-off for predicting significant fibrosis and cirrhosis were relatively similar in patients with normal alanine aminotransferase and in those with alanine aminotransferase levels between 1.1 and 5× the upper limit of normal: 1.29. m/s vs. 1.36. m/s and 1.59. m/s vs. 1.57. m/s, respectively.For predicting cirrhosis, the Transient Elastography cut-offs were significantly higher in patients with alanine aminotransferase levels between 1.1 and 5× the upper limit of normal compared to those with normal alanine aminotransferase: 12.3. kPa vs. 9.1. kPa. Conclusion: Liver stiffness values assessed by Acoustic Radiation Force Impulse and Transient Elastography are influenced by high aminotransferase levels. Transient Elastography was also influenced by moderately elevated aminotransferase levels.
AB - Background: Acoustic Radiation Force Impulse Elastography is a new method for non-invasive evaluation of liver fibrosis. Aim: To evaluate the impact of elevated alanine aminotransferase levels on liver stiffness assessment by Acoustic Radiation Force Impulse Elastography. Methods: A multicentre retrospective study including 1242 patients with chronic liver disease, who underwent liver biopsy and Acoustic Radiation Force Impulse. Transient Elastography was also performed in 512 patients. Results: The best Acoustic Radiation Force Impulse cut-off for predicting significant fibrosis was 1.29. m/s in cases with normal alanine aminotransferase levels and 1.44. m/s in patients with alanine aminotransferase levels. >. 5× the upper limit of normal. The best cut-off for predicting liver cirrhosis were 1.59 and 1.75. m/s, respectively.Acoustic Radiation Force Impulse cut-off for predicting significant fibrosis and cirrhosis were relatively similar in patients with normal alanine aminotransferase and in those with alanine aminotransferase levels between 1.1 and 5× the upper limit of normal: 1.29. m/s vs. 1.36. m/s and 1.59. m/s vs. 1.57. m/s, respectively.For predicting cirrhosis, the Transient Elastography cut-offs were significantly higher in patients with alanine aminotransferase levels between 1.1 and 5× the upper limit of normal compared to those with normal alanine aminotransferase: 12.3. kPa vs. 9.1. kPa. Conclusion: Liver stiffness values assessed by Acoustic Radiation Force Impulse and Transient Elastography are influenced by high aminotransferase levels. Transient Elastography was also influenced by moderately elevated aminotransferase levels.
KW - Acoustic Radiation Force Impulse (ARFI) Elastography
KW - Aminotransferase levels
KW - Liver fibrosis
KW - Liver stiffness
KW - Transient Elastography
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U2 - 10.1016/j.dld.2013.02.008
DO - 10.1016/j.dld.2013.02.008
M3 - Article
C2 - 23510533
AN - SCOPUS:84882249291
SN - 1590-8658
VL - 45
SP - 762
EP - 768
JO - Digestive and Liver Disease
JF - Digestive and Liver Disease
IS - 9
ER -