The influence of cefotaxime on intestinal flora and bleeding diathesis in infants and neonates, compared with other β-lactams

K. Sunakawa, H. Akita, S. Iwata, Y. Sato

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Various second- and third-generation cephem antibiotics were administered to infants 2 years of age or less. Excluding Streptococcus faecalis, which is resistant to cephems, all of the intestinal bacteria decreased in number, and in many cases these were replaced by yeasts. A positive reaction for protein induced by vitamin K absence or antagonism (PIVKA II) occurred in 25 to 63 % of the subjects administered cephems possessing a methylthiotetrazole group, but not in those dosed with cefotaxime or ceftazidime. The effects of cefotaxime and latamoxef (moxalactam) on platelet ADP aggregation were also investigated. When these drugs were administered to clinical patients, moxalactam showed stronger inhibition of aggregation than cefotaxime.

Original languageEnglish
Pages (from-to)317-324
Number of pages8
JournalJournal of Antimicrobial Chemotherapy
Volume14
DOIs
Publication statusPublished - 1984 Jan 1

ASJC Scopus subject areas

  • Pharmacology
  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

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