The influence of cefotaxime on intestinal flora and bleeding diathesis in infants and neonates, compared with other β-lactams

K. Sunakawa; H. Akita; S. Iwata; Y. Sato

doi:10.1093/jac/14.suppl_B.317

The influence of cefotaxime on intestinal flora and bleeding diathesis in infants and neonates, compared with other β-lactams

K. Sunakawa, H. Akita, S. Iwata, Y. Sato

Department of Infectious Diseases

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Various second- and third-generation cephem antibiotics were administered to infants 2 years of age or less. Excluding Streptococcus faecalis, which is resistant to cephems, all of the intestinal bacteria decreased in number, and in many cases these were replaced by yeasts. A positive reaction for protein induced by vitamin K absence or antagonism (PIVKA II) occurred in 25 to 63 % of the subjects administered cephems possessing a methylthiotetrazole group, but not in those dosed with cefotaxime or ceftazidime. The effects of cefotaxime and latamoxef (moxalactam) on platelet ADP aggregation were also investigated. When these drugs were administered to clinical patients, moxalactam showed stronger inhibition of aggregation than cefotaxime.

Original language	English
Pages (from-to)	317-324
Number of pages	8
Journal	Journal of Antimicrobial Chemotherapy
Volume	14
DOIs	https://doi.org/10.1093/jac/14.suppl_B.317
Publication status	Published - 1984

ASJC Scopus subject areas

Pharmacology
Microbiology (medical)
Infectious Diseases
Pharmacology (medical)

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/jac/14.suppl_B.317

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abstract = "Various second- and third-generation cephem antibiotics were administered to infants 2 years of age or less. Excluding Streptococcus faecalis, which is resistant to cephems, all of the intestinal bacteria decreased in number, and in many cases these were replaced by yeasts. A positive reaction for protein induced by vitamin K absence or antagonism (PIVKA II) occurred in 25 to 63 % of the subjects administered cephems possessing a methylthiotetrazole group, but not in those dosed with cefotaxime or ceftazidime. The effects of cefotaxime and latamoxef (moxalactam) on platelet ADP aggregation were also investigated. When these drugs were administered to clinical patients, moxalactam showed stronger inhibition of aggregation than cefotaxime.",

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AU - Sunakawa, K.

AU - Akita, H.

AU - Iwata, S.

AU - Sato, Y.

PY - 1984

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AB - Various second- and third-generation cephem antibiotics were administered to infants 2 years of age or less. Excluding Streptococcus faecalis, which is resistant to cephems, all of the intestinal bacteria decreased in number, and in many cases these were replaced by yeasts. A positive reaction for protein induced by vitamin K absence or antagonism (PIVKA II) occurred in 25 to 63 % of the subjects administered cephems possessing a methylthiotetrazole group, but not in those dosed with cefotaxime or ceftazidime. The effects of cefotaxime and latamoxef (moxalactam) on platelet ADP aggregation were also investigated. When these drugs were administered to clinical patients, moxalactam showed stronger inhibition of aggregation than cefotaxime.

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The influence of cefotaxime on intestinal flora and bleeding diathesis in infants and neonates, compared with other β-lactams

Abstract

ASJC Scopus subject areas

UN SDGs

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