The influence of dietary protein on the synthesis of vasoactive substances in subtotally nephrectomized spontaneously hypertensive rats

K. Hayashi, H. Suzuki, H. Katsumata, A. Ohishi, H. Nakamoto, T. Saruta

Research output: Contribution to journalArticle

Abstract

The effects of dietary protein alterations on the synthesis of prostaglandins and kallikrein were examined in subtotally nephrectomized spontaneously hypertensive rats. Three diets containing 40, 24 and 8% protein were prepared. After subtotal nephrectomy, rats were given one of the three diets for the next 12 weeks. During the study, systolic blood pressure, urinary excretions of protein, 6-keto-prostaglandin F1α, thromboxane B2 and kallikrein were measured every 2 weeks. Although the diets did not prevent the further elevation of systolic blood pressure, the rats on the low protein diet displayed lower serum creatinine levels and urinary protein levels. The urinary excretion of thromboxane B2 was unaffected by the amount of dietary protein, but the urinary excretion of 6-keto-prostaglandin F1α was lower in the low protein diet group. Furthermore, the urinary excretion of kallikrein increased significantly in rats on high protein diet. These results suggest that manipulation of dietary protein may alter the natural course of renal failure induced by subtotal nephrectomy in spontaneously hypertensive rats.

Original languageEnglish
Pages (from-to)917-927
Number of pages11
JournalJapanese Heart Journal
Volume30
Issue number6
Publication statusPublished - 1989

Fingerprint

Dietary Proteins
Inbred SHR Rats
Diet
Blood Pressure
Thromboxane B2
Protein-Restricted Diet
Kallikreins
Nephrectomy
Proteins
Tissue Kallikreins
Prostaglandins
Renal Insufficiency
Creatinine
Serum
prostaglandin F1

Keywords

  • Kallikrein
  • Prostaglandins
  • Renin-angiotensin system

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Hayashi, K., Suzuki, H., Katsumata, H., Ohishi, A., Nakamoto, H., & Saruta, T. (1989). The influence of dietary protein on the synthesis of vasoactive substances in subtotally nephrectomized spontaneously hypertensive rats. Japanese Heart Journal, 30(6), 917-927.

The influence of dietary protein on the synthesis of vasoactive substances in subtotally nephrectomized spontaneously hypertensive rats. / Hayashi, K.; Suzuki, H.; Katsumata, H.; Ohishi, A.; Nakamoto, H.; Saruta, T.

In: Japanese Heart Journal, Vol. 30, No. 6, 1989, p. 917-927.

Research output: Contribution to journalArticle

Hayashi, K, Suzuki, H, Katsumata, H, Ohishi, A, Nakamoto, H & Saruta, T 1989, 'The influence of dietary protein on the synthesis of vasoactive substances in subtotally nephrectomized spontaneously hypertensive rats', Japanese Heart Journal, vol. 30, no. 6, pp. 917-927.
Hayashi, K. ; Suzuki, H. ; Katsumata, H. ; Ohishi, A. ; Nakamoto, H. ; Saruta, T. / The influence of dietary protein on the synthesis of vasoactive substances in subtotally nephrectomized spontaneously hypertensive rats. In: Japanese Heart Journal. 1989 ; Vol. 30, No. 6. pp. 917-927.
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