The Input-Output Relationship of AIY Interneurons in Caenorhabditis elegans in Noisy Environment

K. Ashida, K. Hotta, Kotaro Oka

Research output: Contribution to journalArticle

Abstract

Determining how neurotransmitter input causes various neuronal activities is crucial to understanding neuronal information processing. In Caenorhabditis elegans, AIY interneurons receive several sources of sensory information as glutamate inputs and regulate behavior by integrating these inputs. However, the relationship between glutamate input and the Ca2+ response in AIY under environmental noise, in other words, without explicit stimulation, remains unknown. Here, we show that glutamate-input fluctuations evoke a sporadic Ca2+ response in AIY without stimulation. To ensure that Ca2+ response can be considered AIY output, we show that the membrane-potential depolarization precedes Ca2+ responses in AIY. We used an odor as model stimulation to modulate the sensory inputs. Simultaneous imaging of glutamate input and Ca2+ response, together with glutamate transmission mutants, showed that glutamate-input fluctuations evoke sporadic Ca2+ responses. We identified the input-output relationships under environmental noise in vivo, and our results address the relationship between sensory-input fluctuations and behavioral variability. Neuroscience; Systems Neuroscience; Sensory Neuroscience

Original languageEnglish
Pages (from-to)191-203
Number of pages13
JournaliScience
Volume19
DOIs
Publication statusPublished - 2019 Sep 27

Fingerprint

Caenorhabditis elegans
Interneurons
Glutamic Acid
Neurosciences
Noise
Automatic Data Processing
Membrane Potentials
Neurotransmitter Agents

Keywords

  • Neuroscience
  • Sensory Neuroscience
  • Systems Neuroscience

ASJC Scopus subject areas

  • General

Cite this

The Input-Output Relationship of AIY Interneurons in Caenorhabditis elegans in Noisy Environment. / Ashida, K.; Hotta, K.; Oka, Kotaro.

In: iScience, Vol. 19, 27.09.2019, p. 191-203.

Research output: Contribution to journalArticle

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