The INTERPHONE study: Design, epidemiological methods, and description of the study population

Elisabeth Cardis, Lesley Richardson, Isabelle Deltour, Bruce Armstrong, Maria Feychting, Christoffer Johansen, Monique Kilkenny, Patricia McKinney, Baruch Modan, Siegal Sadetzki, Joachim Schüz, Anthony Swerdlow, Martine Vrijheid, Anssi Auvinen, Gabriele Berg, Maria Blettner, Joseph Bowman, Julianne Brown, Angela Chetrit, Helle Collatz ChristensenAngus Cook, Sarah Hepworth, Graham Giles, Martine Hours, Ivano Iavarone, Avital Jarus-Hakak, Lars Klaeboe, Daniel Krewski, Susanna Lagorio, Stefan Lönn, Simon Mann, Mary McBride, Kenneth Muir, Louise Nadon, Marie Elise Parent, Neil Pearce, Tiina Salminen, Minouk Schoemaker, Brigitte Schlehofer, Jack Siemiatycki, Masao Taki, Toru Takebayashi, Tore Tynes, Martie Van Tongeren, Paolo Vecchia, Joe Wiart, Alistair Woodward, Naohito Yamaguchi

Research output: Contribution to journalArticlepeer-review

201 Citations (Scopus)

Abstract

The very rapid worldwide increase in mobile phone use in the last decade has generated considerable interest in the possible health effects of exposure to radio frequency (RF) fields. A multinational case-control study, INTERPHONE, was set-up to investigate whether mobile phone use increases the risk of cancer and, more specifically, whether the RF fields emitted by mobile phones are carcinogenic. The study focused on tumours arising in the tissues most exposed to RF fields from mobile phones: glioma, meningioma, acoustic neurinoma and parotid gland tumours. In addition to a detailed history of mobile phone use, information was collected on a number of known and potential risk factors for these tumours. The study was conducted in 13 countries. Australia, Canada, Denmark, Finland, France, Germany, Israel, Italy, Japan, New Zealand, Norway, Sweden, and the UK using a common core protocol. This paper describes the study design and methods and the main characteristics of the study population. INTERPHONE is the largest case-control study to date investigating risks related to mobile phone use and to other potential risk factors for the tumours of interest and includes 2,765 glioma, 2,425 meningioma, 1,121 acoustic neurinoma, 109 malignant parotid gland tumour cases and 7,658 controls. Particular attention was paid to estimating the amount and direction of potential recall and participation biases and their impact on the study results.

Original languageEnglish
Pages (from-to)647-664
Number of pages18
JournalEuropean Journal of Epidemiology
Volume22
Issue number9
DOIs
Publication statusPublished - 2007 Sep

Keywords

  • Acoustic neurinoma
  • Benign tumours
  • Brain tumours
  • Cancer
  • Case-control
  • Methods
  • Mobile phones
  • Parotid gland tumours
  • Study design

ASJC Scopus subject areas

  • Epidemiology

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