Abstract
We investigated the expression of surfactant protein (SP)-D in pulmonary epithelial cells, compared with the expression of SP-A. A total of 15 fetuses aborted at 8, 15, 19, 20, 21 and 23 weeks gestation and four premature babies who were stillborn or died after birth between May 1997 and October 2001 were included in this study. Fetuses showing any findings associated with preterm premature rupture of membranes or infection were excluded. We performed immunohistochemical examinations for SP-D and SP-A. SP-D was not detected by immunostaining at 8, 15 and 19 weeks gestation. At 21 weeks gestation, SP-D was weakly localized, in some cases (5/9), in the epithelial lining of both bronchioles and terminal airways. In contrast at 21 weeks gestation, SP-A was more markedly detected in the epithelial lining of both bronchioles and terminal airways in all cases but not detected in bronchioles and terminal airways at 8, 15 and 19 weeks gestation. Conclusion: the findings in this investigation suggests that the production of SP-D in fetal human lungs begins in the bronchiolar and terminal epithelium from about 21 weeks of gestation.
| Original language | English |
|---|---|
| Pages (from-to) | 431-434 |
| Number of pages | 4 |
| Journal | European Journal of Pediatrics |
| Volume | 161 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2002 |
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Keywords
- Human fetus
- Pulmonary epithelial cell
- Surfactant proteins A and D
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
The intrauterine expression of surfactant protein D in the terminal airways of human fetuses compared with surfactant protein A. / Mori, Kazuhiro; Kurihara, Nobuyoshi; Hayashida, Shinya; Tanaka, Mamoru; Ikeda, Kazushige.
In: European Journal of Pediatrics, Vol. 161, No. 8, 2002, p. 431-434.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The intrauterine expression of surfactant protein D in the terminal airways of human fetuses compared with surfactant protein A
AU - Mori, Kazuhiro
AU - Kurihara, Nobuyoshi
AU - Hayashida, Shinya
AU - Tanaka, Mamoru
AU - Ikeda, Kazushige
PY - 2002
Y1 - 2002
N2 - We investigated the expression of surfactant protein (SP)-D in pulmonary epithelial cells, compared with the expression of SP-A. A total of 15 fetuses aborted at 8, 15, 19, 20, 21 and 23 weeks gestation and four premature babies who were stillborn or died after birth between May 1997 and October 2001 were included in this study. Fetuses showing any findings associated with preterm premature rupture of membranes or infection were excluded. We performed immunohistochemical examinations for SP-D and SP-A. SP-D was not detected by immunostaining at 8, 15 and 19 weeks gestation. At 21 weeks gestation, SP-D was weakly localized, in some cases (5/9), in the epithelial lining of both bronchioles and terminal airways. In contrast at 21 weeks gestation, SP-A was more markedly detected in the epithelial lining of both bronchioles and terminal airways in all cases but not detected in bronchioles and terminal airways at 8, 15 and 19 weeks gestation. Conclusion: the findings in this investigation suggests that the production of SP-D in fetal human lungs begins in the bronchiolar and terminal epithelium from about 21 weeks of gestation.
AB - We investigated the expression of surfactant protein (SP)-D in pulmonary epithelial cells, compared with the expression of SP-A. A total of 15 fetuses aborted at 8, 15, 19, 20, 21 and 23 weeks gestation and four premature babies who were stillborn or died after birth between May 1997 and October 2001 were included in this study. Fetuses showing any findings associated with preterm premature rupture of membranes or infection were excluded. We performed immunohistochemical examinations for SP-D and SP-A. SP-D was not detected by immunostaining at 8, 15 and 19 weeks gestation. At 21 weeks gestation, SP-D was weakly localized, in some cases (5/9), in the epithelial lining of both bronchioles and terminal airways. In contrast at 21 weeks gestation, SP-A was more markedly detected in the epithelial lining of both bronchioles and terminal airways in all cases but not detected in bronchioles and terminal airways at 8, 15 and 19 weeks gestation. Conclusion: the findings in this investigation suggests that the production of SP-D in fetal human lungs begins in the bronchiolar and terminal epithelium from about 21 weeks of gestation.
KW - Human fetus
KW - Pulmonary epithelial cell
KW - Surfactant proteins A and D
UR - http://www.scopus.com/inward/record.url?scp=0036354722&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036354722&partnerID=8YFLogxK
U2 - 10.1007/s00431-002-0917-9
DO - 10.1007/s00431-002-0917-9
M3 - Article
C2 - 12172826
AN - SCOPUS:0036354722
VL - 161
SP - 431
EP - 434
JO - European Journal of Pediatrics
JF - European Journal of Pediatrics
SN - 0340-6199
IS - 8
ER -