The intrauterine expression of surfactant protein D in the terminal airways of human fetuses compared with surfactant protein A

Kazuhiro Mori, Nobuyoshi Kurihara, Shinya Hayashida, Mamoru Tanaka, Kazushige Ikeda

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

We investigated the expression of surfactant protein (SP)-D in pulmonary epithelial cells, compared with the expression of SP-A. A total of 15 fetuses aborted at 8, 15, 19, 20, 21 and 23 weeks gestation and four premature babies who were stillborn or died after birth between May 1997 and October 2001 were included in this study. Fetuses showing any findings associated with preterm premature rupture of membranes or infection were excluded. We performed immunohistochemical examinations for SP-D and SP-A. SP-D was not detected by immunostaining at 8, 15 and 19 weeks gestation. At 21 weeks gestation, SP-D was weakly localized, in some cases (5/9), in the epithelial lining of both bronchioles and terminal airways. In contrast at 21 weeks gestation, SP-A was more markedly detected in the epithelial lining of both bronchioles and terminal airways in all cases but not detected in bronchioles and terminal airways at 8, 15 and 19 weeks gestation. Conclusion: the findings in this investigation suggests that the production of SP-D in fetal human lungs begins in the bronchiolar and terminal epithelium from about 21 weeks of gestation.

Original languageEnglish
Pages (from-to)431-434
Number of pages4
JournalEuropean Journal of Pediatrics
Volume161
Issue number8
DOIs
Publication statusPublished - 2002

Fingerprint

Pulmonary Surfactant-Associated Protein D
Pulmonary Surfactant-Associated Protein A
Fetus
Bronchioles
Pregnancy
Aborted Fetus
Epithelium
Epithelial Cells
Parturition
Lung
Infection

Keywords

  • Human fetus
  • Pulmonary epithelial cell
  • Surfactant proteins A and D

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

The intrauterine expression of surfactant protein D in the terminal airways of human fetuses compared with surfactant protein A. / Mori, Kazuhiro; Kurihara, Nobuyoshi; Hayashida, Shinya; Tanaka, Mamoru; Ikeda, Kazushige.

In: European Journal of Pediatrics, Vol. 161, No. 8, 2002, p. 431-434.

Research output: Contribution to journalArticle

Mori, Kazuhiro ; Kurihara, Nobuyoshi ; Hayashida, Shinya ; Tanaka, Mamoru ; Ikeda, Kazushige. / The intrauterine expression of surfactant protein D in the terminal airways of human fetuses compared with surfactant protein A. In: European Journal of Pediatrics. 2002 ; Vol. 161, No. 8. pp. 431-434.
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