The isolation and synthesis of two novel N-acetyl glucosamine derivatives from Dictyostelium cellular slime molds which exhibit neurite outgrowth activity

Haruhisa Kikuchi, Jun Komiya, Yoshinori Saito, Jun Ichi Sekiya, Shigeyoshi Honma, Norimichi Nakahata, Yoshiteru Oshima

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

To clarify the diversity of secondary metabolites of Dictyostelium cellular slime molds and explore any biologically active substances which they may hold, constituents of two species were investigated. From a methanol extract of their fruit bodies, two novel acylated amino sugars were isolated, dictyoglucosamine A (1) from D. purpureum and dictyoglucosamine B (2) from D. discoideum. For further analysis, these compounds were then synthesized from N-acetyl-D-glucosamine. Biological evaluation of 1 and 2 showed they induce neuronal differentiation of rat pheochromocytoma (PC-12) cells.

Original languageEnglish
Pages (from-to)1477-1480
Number of pages4
JournalTetrahedron Letters
Volume43
Issue number8
DOIs
Publication statusPublished - 2002 Feb 18
Externally publishedYes

Keywords

  • Amino sugars
  • Cellular slime molds
  • Differentiation
  • PC-12 cell

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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