The Japan Multi-institutional Collaborative Cohort Study (JMICC Study) to detect gene-environment interactions for cancer

Nobuyuki Hamajima, Kenji Wakai, Mariko Naito, Kazuko Nishio, Yoshiko Ishida, Rieko Okada, Kaori Masui, Emi Morita, Tetsuo Kuroishi, Chiba Cohort, Haruo Mikami, Miki Ohira, Shuichi Fujimoto, Kimiko Takayama, Eiji Maruyama, Yuka Orii, Keiko Sato, Toru Masui, Kenji Matsui, Akiko Tamakoshi.Shuji Hashimoto, Kei Nakachi, Kazue Imai, Hidetaka Eguchi, Takashi Takahashi, Akira Okayama, Yoichi Kurosawa, Takeo Nakayama, Kaori Muto, Zentaro Yamagata, Yatami Asai, Masumi Suzuki, Hiroko Fukada, Akiko Tomoda, Yasoko Misu, Shiro Katase, Satoru Tokumasu, Yoko Kato, Murakami Yoichi, Koyama Atsushi, Kazuo Tajima, Kaoru Hirose, Akio Hiraki, Keitaro Matsuo, Takeshi Suzuki, Kiyonori Kuriki, Toshiko Saito, Miki Watanabe, Sadao Suzuki, Shinkan Tokudome, Akihiro Hosono, Kazuyuki Arakawa, Nami Hattori, Ryosuke Ando, Tsutomu Tanaka, Yukiko Kitabayashi, Hirotsugu Ueshima, Yoshikuni Kita, Yasuyuki Nakamura, Kenji Matsui, Takako Yamamoto, Turin Tanvir Chowdhury, Hideki Sugihara, Yutaka Morita, Nobuyoshi Tomioka, Yoshiyuki Watanabe, Kotaro Ozasa, Mariko Yuge, Kyohei Hayashi, Masako Shigeta, Satoko Mitani, Etsuko Ozaki, Daisuke Matsui, Tomio Sakazaki, Kokichi Arisawa, Hirokazu Uemura, Mineyoshi Hiyoshi, Yasunobu Sagara, Suminori Kono, Guang Yin, Jun Nagano, Tetsuya Mizoue, Ryoichi Takayanagi, Keizo Ohnaka, Hisaya Kawate, Masahiro Adachi, Malcolm A. Moore, Kengo Toyomura, Kayoko Isomura, Tomoko Hagiwara, Jin Fukumoto, Akiko Nanri, Taiki Yamaji, Daigo Yoshida, Makiko Morita, Naoyuki Ueda, Takako Maki, Mizuko Ikeda, Keitaro Tanaka, Koichi Shinchi, Yasuki Higaki, Megumi Hara, Tatsuhiko Sakamoto, Takeshi Imaizumi, Naoto Taguchi, Mikako Horita, Toshiro Takezaki, Hideshi Niimura, Kazuyo Kuwabara, Masaya Tatebou, Tsunematsu Noriko, Ken Kus

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Abstract

The Japan Multi-institutional Collaborative Cohort Study (J-MICC Study) launched in 2005, supported by a research grant for Scientific Research on Special Priority Areas of Cancer from the Japanese Ministry of Education, Culture, Sports, Science and Technology. Although the main purpose is to confirm and detect gene-environment interactions of lifestyle-related diseases, mainly of cancer, through the cohort analyses, it includes cross-sectional analyses on lifestyle factors, biomarkers, and genotypes, as well as confirmation/screening of new biomarkers usable for early diagnosis of cancer. The endpoints are cancer diagnosis and death. The participants diagnosed as cancer will be identified through population-based cancer registries, hospital cancer registries, mail questionnaires, questionnaires at repeated visits, death certificates, health insurance data, and second survey questionnaires. Subjects are individuals aged 35 to 69 years enrolled from respondents to study announcements in specified areas, inhabitants attending health checkup examinations by local governments, visitors at health checkup centers, and patients at a cancer hospital. The number of subjects was set to be 100,000 throughout Japan. The enrollment period is from April 2005 to March 2010. The second survey is scheduled 5 years after their enrollment. The participants will be followed until 2025. The J-MICC Central Office is placed at Nagoya University Graduate School of Medicine. Ten participating research groups (Cohort Study Executing Groups) send baseline data and blood samples (buffy coat, serum, and plasma) anonymized with an identification number (J-MICC ID) to the Central Office. The data of second survey and follow-up will be linked using J-MICC ID. This study is expected to produce many findings on lifestyle and genetic traits associated with lifestyle-related diseases including cancer among Japanese.

Original languageEnglish
Pages (from-to)317-323
Number of pages7
JournalAsian Pacific Journal of Cancer Prevention
Volume8
Issue number2
Publication statusPublished - 2007
Externally publishedYes

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Keywords

  • Biomarkers\lifestyle-related diseases\cancer
  • Cohort study
  • Gene-environment interactions

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Public Health, Environmental and Occupational Health
  • Epidemiology
  • Medicine(all)

Cite this

Hamajima, N., Wakai, K., Naito, M., Nishio, K., Ishida, Y., Okada, R., Masui, K., Morita, E., Kuroishi, T., Cohort, C., Mikami, H., Ohira, M., Fujimoto, S., Takayama, K., Maruyama, E., Orii, Y., Sato, K., Masui, T., Matsui, K., ... Kus, K. (2007). The Japan Multi-institutional Collaborative Cohort Study (JMICC Study) to detect gene-environment interactions for cancer. Asian Pacific Journal of Cancer Prevention, 8(2), 317-323.