The key entity of a DCAR agonist, phosphatidylinositol mannoside Ac1PIM1: Its synthesis and immunomodulatory function

Yohei Arai, Shota Torigoe, Takanori Matsumaru, Sho Yamasaki, Yukari Fujimoto

Research output: Contribution to journalArticle

Abstract

Ac1PIM1is a potential biosynthetic intermediate for phosphatidylinositol mannosides (PIMs) fromMycobacterium tuberculosis. We achieved the first synthesis of Ac1PIM1by utilizing an allyl-type protecting group strategy and regioselective phosphorylation of inositol. A very potent agonist of an innate immune receptor DCAR, which is better than previously known agonists, is demonstrated.

Original languageEnglish
Pages (from-to)3659-3663
Number of pages5
JournalOrganic and Biomolecular Chemistry
Volume18
Issue number19
DOIs
Publication statusPublished - 2020 May 21

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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