Abstract
Ac1PIM1is a potential biosynthetic intermediate for phosphatidylinositol mannosides (PIMs) fromMycobacterium tuberculosis. We achieved the first synthesis of Ac1PIM1by utilizing an allyl-type protecting group strategy and regioselective phosphorylation of inositol. A very potent agonist of an innate immune receptor DCAR, which is better than previously known agonists, is demonstrated.
| Original language | English |
|---|---|
| Pages (from-to) | 3659-3663 |
| Number of pages | 5 |
| Journal | Organic and Biomolecular Chemistry |
| Volume | 18 |
| Issue number | 19 |
| DOIs | |
| Publication status | Published - 2020 May 21 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
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Arai, Y., Torigoe, S., Matsumaru, T., Yamasaki, S., & Fujimoto, Y. (2020). The key entity of a DCAR agonist, phosphatidylinositol mannoside Ac1PIM1: Its synthesis and immunomodulatory function. Organic and Biomolecular Chemistry, 18(19), 3659-3663. https://doi.org/10.1039/c9ob02724f