Abstract
Ac1PIM1is a potential biosynthetic intermediate for phosphatidylinositol mannosides (PIMs) fromMycobacterium tuberculosis. We achieved the first synthesis of Ac1PIM1by utilizing an allyl-type protecting group strategy and regioselective phosphorylation of inositol. A very potent agonist of an innate immune receptor DCAR, which is better than previously known agonists, is demonstrated.
Original language | English |
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Pages (from-to) | 3659-3663 |
Number of pages | 5 |
Journal | Organic and Biomolecular Chemistry |
Volume | 18 |
Issue number | 19 |
DOIs | |
Publication status | Published - 2020 May 21 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry