@article{edd6211bc4174e109eeb38622614de61,
title = "The key entity of a DCAR agonist, phosphatidylinositol mannoside Ac1PIM1: Its synthesis and immunomodulatory function",
abstract = "Ac1PIM1is a potential biosynthetic intermediate for phosphatidylinositol mannosides (PIMs) fromMycobacterium tuberculosis. We achieved the first synthesis of Ac1PIM1by utilizing an allyl-type protecting group strategy and regioselective phosphorylation of inositol. A very potent agonist of an innate immune receptor DCAR, which is better than previously known agonists, is demonstrated.",
author = "Yohei Arai and Shota Torigoe and Takanori Matsumaru and Sho Yamasaki and Yukari Fujimoto",
note = "Funding Information: This research was also financially supported by JSPS KAKENHI (No. JP17H02207, JP18H04426, JP19H04815, JP19J13192, and JP17H05800), by AMED under Grant Numbers JP19ae0101052, JP19gm0910010, JP19ak0101070, JP19fk0108075 and by Takeda Science Foundation. Funding Information: We thank Prof. Kazuya Iwabuchi (Kitasato University) and Dr Kazuya Kabayama (Osaka University) for providing 2E10 hybridoma, and also thank Prof. Koichi Kato and Dr Saeko Yanaka (Institute for Molecular Science) for high resolution NMR measurements, supported by Nanotechnology Platform Program (Molecule and Material Synthesis) of the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2020.",
year = "2020",
month = may,
day = "21",
doi = "10.1039/c9ob02724f",
language = "English",
volume = "18",
pages = "3659--3663",
journal = "Organic and Biomolecular Chemistry",
issn = "1477-0520",
publisher = "Royal Society of Chemistry",
number = "19",
}
