The laser driven short-term heating balloon catheter: Relation between the chronic neointimal hyperplasia formation and thermal damage to arterial smooth muscle cells

Natsumi Shimazaki, Tomoaki Hayashi, Mie Kunio, Yuka Igami, Tsunenori Arai, Masami Sakurada

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

We proposed a novel laser-driven short-term heating angioplasty to realize restenosis-suppressive angioplasty for peripheral artery disease. In this study, we investigated the chronic intimal hyperplasia formation after the short-term heating dilatation in vivo, as well as the thermal damage calculation on arterial smooth muscle cells (SMCs). The prototype short-term heating balloon catheter with 5.0, 5.5, 6.0 mm φ in balloon diameter and 25mm in balloon length were employed. The short-term heating dilatation was performed in porcine iliac arteries with dilatation conditions of 75° (N=4) and 65° (N=5) as peak balloon temperature, 18± 4s as heating duration, 3.5atm as balloon dilatation pressure. Four weeks after the balloon dilatation, the balloon-dilated artery segments were extracted and were stained with HE and picrosirius red for histological observation. In the case of 75° as the peak balloon temperature, neointimal hyperplasia formation was significantly reduced. In this case, the SMCs density in the artery media measured from the HE-stained specimen was 20% lower than that in the reference artery. According to the thermal damage calculation, it was estimated that the SMCs lethality in artery media after the short-term heating angioplasty was 20% in the case of 75° as the peak balloon temperature. We demonstrated that the short-term heating dilatation reduced the number of SMCs in artery media. We think this SMCs reduction might contribute to the suppression of chronic neointimal hyperplasia.

Original languageEnglish
Title of host publication2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10
Pages1618-1621
Number of pages4
DOIs
Publication statusPublished - 2010
Event2010 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10 - Buenos Aires, Argentina
Duration: 2010 Aug 312010 Sep 4

Other

Other2010 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10
CountryArgentina
CityBuenos Aires
Period10/8/3110/9/4

Fingerprint

Catheters
Balloons
Muscle
Cells
Heating
Lasers
Hot Temperature
Temperature

ASJC Scopus subject areas

  • Biomedical Engineering

Cite this

Shimazaki, N., Hayashi, T., Kunio, M., Igami, Y., Arai, T., & Sakurada, M. (2010). The laser driven short-term heating balloon catheter: Relation between the chronic neointimal hyperplasia formation and thermal damage to arterial smooth muscle cells. In 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10 (pp. 1618-1621). [5626651] https://doi.org/10.1109/IEMBS.2010.5626651

The laser driven short-term heating balloon catheter : Relation between the chronic neointimal hyperplasia formation and thermal damage to arterial smooth muscle cells. / Shimazaki, Natsumi; Hayashi, Tomoaki; Kunio, Mie; Igami, Yuka; Arai, Tsunenori; Sakurada, Masami.

2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10. 2010. p. 1618-1621 5626651.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Shimazaki, N, Hayashi, T, Kunio, M, Igami, Y, Arai, T & Sakurada, M 2010, The laser driven short-term heating balloon catheter: Relation between the chronic neointimal hyperplasia formation and thermal damage to arterial smooth muscle cells. in 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10., 5626651, pp. 1618-1621, 2010 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10, Buenos Aires, Argentina, 10/8/31. https://doi.org/10.1109/IEMBS.2010.5626651
Shimazaki N, Hayashi T, Kunio M, Igami Y, Arai T, Sakurada M. The laser driven short-term heating balloon catheter: Relation between the chronic neointimal hyperplasia formation and thermal damage to arterial smooth muscle cells. In 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10. 2010. p. 1618-1621. 5626651 https://doi.org/10.1109/IEMBS.2010.5626651
Shimazaki, Natsumi ; Hayashi, Tomoaki ; Kunio, Mie ; Igami, Yuka ; Arai, Tsunenori ; Sakurada, Masami. / The laser driven short-term heating balloon catheter : Relation between the chronic neointimal hyperplasia formation and thermal damage to arterial smooth muscle cells. 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10. 2010. pp. 1618-1621
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