The lipocalin 24p3, which is an essential molecule in IL-3 withdrawal-induced apoptosis, is not involved in the G-CSF withdrawal-induced apoptosis

Kenjirou Kamezaki, Kazuya Shimoda, Akihiko Numata, Kenichi Aoki, Kouji Kato, Ken Takase, Hideaki Nakajima, Kenji Ihara, Takashi Haro, Fumihiko Ishikawa, Rie Imamura, Toshihiro Miyamoto, Koji Nagafuji, Hisashi Gondo, Toshiro Hara, Mine Harada

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Many hematopoietic cells undergo apoptosis when deprived of specific cytokines. Lipocalin 24p3, reported to be induced in hematopoietic cells by interleukin 3 (IL-3) depletion, induces hematopoietic cell apoptosis despite the presence of IL-3. As granulocyte colony stimulating factor (G-CSF) depletion also induces the apoptosis of G-CSF-dependent cell line cells, we examined the effect of 24p3 on the apoptotic function induced by G-CSF depletion. 24p3 was induced by the depletion of IL-3, but not G-CSF, in cytokine-dependent cell lines. Although 24p3 suppressed growth induced by IL-3, it did not influence G-CSF-dependent cell growth. These observations show that 24p3 is not involved in the G-CSF withdrawal-induced apoptosis, although it is essential in IL-3 withdrawal-induced apoptosis.

Original languageEnglish
Pages (from-to)412-417
Number of pages6
JournalEuropean Journal of Haematology
Volume71
Issue number6
DOIs
Publication statusPublished - 2003 Dec
Externally publishedYes

Fingerprint

Lipocalins
Interleukin-3
Granulocyte Colony-Stimulating Factor
Apoptosis
Cytokines
Cell Line
Growth

Keywords

  • 24p3
  • Apoptosis
  • Granulocyte colony stimulating factor
  • Interleukin 3
  • Stat3

ASJC Scopus subject areas

  • Hematology

Cite this

The lipocalin 24p3, which is an essential molecule in IL-3 withdrawal-induced apoptosis, is not involved in the G-CSF withdrawal-induced apoptosis. / Kamezaki, Kenjirou; Shimoda, Kazuya; Numata, Akihiko; Aoki, Kenichi; Kato, Kouji; Takase, Ken; Nakajima, Hideaki; Ihara, Kenji; Haro, Takashi; Ishikawa, Fumihiko; Imamura, Rie; Miyamoto, Toshihiro; Nagafuji, Koji; Gondo, Hisashi; Hara, Toshiro; Harada, Mine.

In: European Journal of Haematology, Vol. 71, No. 6, 12.2003, p. 412-417.

Research output: Contribution to journalArticle

Kamezaki, K, Shimoda, K, Numata, A, Aoki, K, Kato, K, Takase, K, Nakajima, H, Ihara, K, Haro, T, Ishikawa, F, Imamura, R, Miyamoto, T, Nagafuji, K, Gondo, H, Hara, T & Harada, M 2003, 'The lipocalin 24p3, which is an essential molecule in IL-3 withdrawal-induced apoptosis, is not involved in the G-CSF withdrawal-induced apoptosis', European Journal of Haematology, vol. 71, no. 6, pp. 412-417. https://doi.org/10.1046/j.0902-4441.2003.00160.x
Kamezaki, Kenjirou ; Shimoda, Kazuya ; Numata, Akihiko ; Aoki, Kenichi ; Kato, Kouji ; Takase, Ken ; Nakajima, Hideaki ; Ihara, Kenji ; Haro, Takashi ; Ishikawa, Fumihiko ; Imamura, Rie ; Miyamoto, Toshihiro ; Nagafuji, Koji ; Gondo, Hisashi ; Hara, Toshiro ; Harada, Mine. / The lipocalin 24p3, which is an essential molecule in IL-3 withdrawal-induced apoptosis, is not involved in the G-CSF withdrawal-induced apoptosis. In: European Journal of Haematology. 2003 ; Vol. 71, No. 6. pp. 412-417.
@article{0373da3d01ab43408b90d43de23a2d75,
title = "The lipocalin 24p3, which is an essential molecule in IL-3 withdrawal-induced apoptosis, is not involved in the G-CSF withdrawal-induced apoptosis",
abstract = "Many hematopoietic cells undergo apoptosis when deprived of specific cytokines. Lipocalin 24p3, reported to be induced in hematopoietic cells by interleukin 3 (IL-3) depletion, induces hematopoietic cell apoptosis despite the presence of IL-3. As granulocyte colony stimulating factor (G-CSF) depletion also induces the apoptosis of G-CSF-dependent cell line cells, we examined the effect of 24p3 on the apoptotic function induced by G-CSF depletion. 24p3 was induced by the depletion of IL-3, but not G-CSF, in cytokine-dependent cell lines. Although 24p3 suppressed growth induced by IL-3, it did not influence G-CSF-dependent cell growth. These observations show that 24p3 is not involved in the G-CSF withdrawal-induced apoptosis, although it is essential in IL-3 withdrawal-induced apoptosis.",
keywords = "24p3, Apoptosis, Granulocyte colony stimulating factor, Interleukin 3, Stat3",
author = "Kenjirou Kamezaki and Kazuya Shimoda and Akihiko Numata and Kenichi Aoki and Kouji Kato and Ken Takase and Hideaki Nakajima and Kenji Ihara and Takashi Haro and Fumihiko Ishikawa and Rie Imamura and Toshihiro Miyamoto and Koji Nagafuji and Hisashi Gondo and Toshiro Hara and Mine Harada",
year = "2003",
month = "12",
doi = "10.1046/j.0902-4441.2003.00160.x",
language = "English",
volume = "71",
pages = "412--417",
journal = "European Journal of Haematology",
issn = "0902-4441",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - The lipocalin 24p3, which is an essential molecule in IL-3 withdrawal-induced apoptosis, is not involved in the G-CSF withdrawal-induced apoptosis

AU - Kamezaki, Kenjirou

AU - Shimoda, Kazuya

AU - Numata, Akihiko

AU - Aoki, Kenichi

AU - Kato, Kouji

AU - Takase, Ken

AU - Nakajima, Hideaki

AU - Ihara, Kenji

AU - Haro, Takashi

AU - Ishikawa, Fumihiko

AU - Imamura, Rie

AU - Miyamoto, Toshihiro

AU - Nagafuji, Koji

AU - Gondo, Hisashi

AU - Hara, Toshiro

AU - Harada, Mine

PY - 2003/12

Y1 - 2003/12

N2 - Many hematopoietic cells undergo apoptosis when deprived of specific cytokines. Lipocalin 24p3, reported to be induced in hematopoietic cells by interleukin 3 (IL-3) depletion, induces hematopoietic cell apoptosis despite the presence of IL-3. As granulocyte colony stimulating factor (G-CSF) depletion also induces the apoptosis of G-CSF-dependent cell line cells, we examined the effect of 24p3 on the apoptotic function induced by G-CSF depletion. 24p3 was induced by the depletion of IL-3, but not G-CSF, in cytokine-dependent cell lines. Although 24p3 suppressed growth induced by IL-3, it did not influence G-CSF-dependent cell growth. These observations show that 24p3 is not involved in the G-CSF withdrawal-induced apoptosis, although it is essential in IL-3 withdrawal-induced apoptosis.

AB - Many hematopoietic cells undergo apoptosis when deprived of specific cytokines. Lipocalin 24p3, reported to be induced in hematopoietic cells by interleukin 3 (IL-3) depletion, induces hematopoietic cell apoptosis despite the presence of IL-3. As granulocyte colony stimulating factor (G-CSF) depletion also induces the apoptosis of G-CSF-dependent cell line cells, we examined the effect of 24p3 on the apoptotic function induced by G-CSF depletion. 24p3 was induced by the depletion of IL-3, but not G-CSF, in cytokine-dependent cell lines. Although 24p3 suppressed growth induced by IL-3, it did not influence G-CSF-dependent cell growth. These observations show that 24p3 is not involved in the G-CSF withdrawal-induced apoptosis, although it is essential in IL-3 withdrawal-induced apoptosis.

KW - 24p3

KW - Apoptosis

KW - Granulocyte colony stimulating factor

KW - Interleukin 3

KW - Stat3

UR - http://www.scopus.com/inward/record.url?scp=10744233531&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=10744233531&partnerID=8YFLogxK

U2 - 10.1046/j.0902-4441.2003.00160.x

DO - 10.1046/j.0902-4441.2003.00160.x

M3 - Article

C2 - 14703690

AN - SCOPUS:10744233531

VL - 71

SP - 412

EP - 417

JO - European Journal of Haematology

JF - European Journal of Haematology

SN - 0902-4441

IS - 6

ER -