Abstract
Many hematopoietic cells undergo apoptosis when deprived of specific cytokines. Lipocalin 24p3, reported to be induced in hematopoietic cells by interleukin 3 (IL-3) depletion, induces hematopoietic cell apoptosis despite the presence of IL-3. As granulocyte colony stimulating factor (G-CSF) depletion also induces the apoptosis of G-CSF-dependent cell line cells, we examined the effect of 24p3 on the apoptotic function induced by G-CSF depletion. 24p3 was induced by the depletion of IL-3, but not G-CSF, in cytokine-dependent cell lines. Although 24p3 suppressed growth induced by IL-3, it did not influence G-CSF-dependent cell growth. These observations show that 24p3 is not involved in the G-CSF withdrawal-induced apoptosis, although it is essential in IL-3 withdrawal-induced apoptosis.
Original language | English |
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Pages (from-to) | 412-417 |
Number of pages | 6 |
Journal | European Journal of Haematology |
Volume | 71 |
Issue number | 6 |
DOIs | |
Publication status | Published - 2003 Dec |
Keywords
- 24p3
- Apoptosis
- Granulocyte colony stimulating factor
- Interleukin 3
- Stat3
ASJC Scopus subject areas
- Hematology