Abstract
Many hematopoietic cells undergo apoptosis when deprived of specific cytokines. Lipocalin 24p3, reported to be induced in hematopoietic cells by interleukin 3 (IL-3) depletion, induces hematopoietic cell apoptosis despite the presence of IL-3. As granulocyte colony stimulating factor (G-CSF) depletion also induces the apoptosis of G-CSF-dependent cell line cells, we examined the effect of 24p3 on the apoptotic function induced by G-CSF depletion. 24p3 was induced by the depletion of IL-3, but not G-CSF, in cytokine-dependent cell lines. Although 24p3 suppressed growth induced by IL-3, it did not influence G-CSF-dependent cell growth. These observations show that 24p3 is not involved in the G-CSF withdrawal-induced apoptosis, although it is essential in IL-3 withdrawal-induced apoptosis.
| Original language | English |
|---|---|
| Pages (from-to) | 412-417 |
| Number of pages | 6 |
| Journal | European Journal of Haematology |
| Volume | 71 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2003 Dec |
| Externally published | Yes |
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Keywords
- 24p3
- Apoptosis
- Granulocyte colony stimulating factor
- Interleukin 3
- Stat3
ASJC Scopus subject areas
- Hematology
Cite this
The lipocalin 24p3, which is an essential molecule in IL-3 withdrawal-induced apoptosis, is not involved in the G-CSF withdrawal-induced apoptosis. / Kamezaki, Kenjirou; Shimoda, Kazuya; Numata, Akihiko; Aoki, Kenichi; Kato, Kouji; Takase, Ken; Nakajima, Hideaki; Ihara, Kenji; Haro, Takashi; Ishikawa, Fumihiko; Imamura, Rie; Miyamoto, Toshihiro; Nagafuji, Koji; Gondo, Hisashi; Hara, Toshiro; Harada, Mine.
In: European Journal of Haematology, Vol. 71, No. 6, 12.2003, p. 412-417.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The lipocalin 24p3, which is an essential molecule in IL-3 withdrawal-induced apoptosis, is not involved in the G-CSF withdrawal-induced apoptosis
AU - Kamezaki, Kenjirou
AU - Shimoda, Kazuya
AU - Numata, Akihiko
AU - Aoki, Kenichi
AU - Kato, Kouji
AU - Takase, Ken
AU - Nakajima, Hideaki
AU - Ihara, Kenji
AU - Haro, Takashi
AU - Ishikawa, Fumihiko
AU - Imamura, Rie
AU - Miyamoto, Toshihiro
AU - Nagafuji, Koji
AU - Gondo, Hisashi
AU - Hara, Toshiro
AU - Harada, Mine
PY - 2003/12
Y1 - 2003/12
N2 - Many hematopoietic cells undergo apoptosis when deprived of specific cytokines. Lipocalin 24p3, reported to be induced in hematopoietic cells by interleukin 3 (IL-3) depletion, induces hematopoietic cell apoptosis despite the presence of IL-3. As granulocyte colony stimulating factor (G-CSF) depletion also induces the apoptosis of G-CSF-dependent cell line cells, we examined the effect of 24p3 on the apoptotic function induced by G-CSF depletion. 24p3 was induced by the depletion of IL-3, but not G-CSF, in cytokine-dependent cell lines. Although 24p3 suppressed growth induced by IL-3, it did not influence G-CSF-dependent cell growth. These observations show that 24p3 is not involved in the G-CSF withdrawal-induced apoptosis, although it is essential in IL-3 withdrawal-induced apoptosis.
AB - Many hematopoietic cells undergo apoptosis when deprived of specific cytokines. Lipocalin 24p3, reported to be induced in hematopoietic cells by interleukin 3 (IL-3) depletion, induces hematopoietic cell apoptosis despite the presence of IL-3. As granulocyte colony stimulating factor (G-CSF) depletion also induces the apoptosis of G-CSF-dependent cell line cells, we examined the effect of 24p3 on the apoptotic function induced by G-CSF depletion. 24p3 was induced by the depletion of IL-3, but not G-CSF, in cytokine-dependent cell lines. Although 24p3 suppressed growth induced by IL-3, it did not influence G-CSF-dependent cell growth. These observations show that 24p3 is not involved in the G-CSF withdrawal-induced apoptosis, although it is essential in IL-3 withdrawal-induced apoptosis.
KW - 24p3
KW - Apoptosis
KW - Granulocyte colony stimulating factor
KW - Interleukin 3
KW - Stat3
UR - http://www.scopus.com/inward/record.url?scp=10744233531&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=10744233531&partnerID=8YFLogxK
U2 - 10.1046/j.0902-4441.2003.00160.x
DO - 10.1046/j.0902-4441.2003.00160.x
M3 - Article
C2 - 14703690
AN - SCOPUS:10744233531
VL - 71
SP - 412
EP - 417
JO - European Journal of Haematology
JF - European Journal of Haematology
SN - 0902-4441
IS - 6
ER -