The lipocalin 24p3, which is an essential molecule in IL-3 withdrawal-induced apoptosis, is not involved in the G-CSF withdrawal-induced apoptosis

Kenjirou Kamezaki; Kazuya Shimoda; Akihiko Numata; Kenichi Aoki; Kouji Kato; Ken Takase; Hideaki Nakajima; Kenji Ihara; Takashi Haro; Fumihiko Ishikawa; Rie Imamura; Toshihiro Miyamoto; Koji Nagafuji; Hisashi Gondo; Toshiro Hara; Mine Harada

doi:10.1046/j.0902-4441.2003.00160.x

The lipocalin 24p3, which is an essential molecule in IL-3 withdrawal-induced apoptosis, is not involved in the G-CSF withdrawal-induced apoptosis

Kenjirou Kamezaki, Kazuya Shimoda, Akihiko Numata, Kenichi Aoki, Kouji Kato, Ken Takase, Hideaki Nakajima, Kenji Ihara, Takashi Haro, Fumihiko Ishikawa, Rie Imamura, Toshihiro Miyamoto, Koji Nagafuji, Hisashi Gondo, Toshiro Hara, Mine Harada

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Many hematopoietic cells undergo apoptosis when deprived of specific cytokines. Lipocalin 24p3, reported to be induced in hematopoietic cells by interleukin 3 (IL-3) depletion, induces hematopoietic cell apoptosis despite the presence of IL-3. As granulocyte colony stimulating factor (G-CSF) depletion also induces the apoptosis of G-CSF-dependent cell line cells, we examined the effect of 24p3 on the apoptotic function induced by G-CSF depletion. 24p3 was induced by the depletion of IL-3, but not G-CSF, in cytokine-dependent cell lines. Although 24p3 suppressed growth induced by IL-3, it did not influence G-CSF-dependent cell growth. These observations show that 24p3 is not involved in the G-CSF withdrawal-induced apoptosis, although it is essential in IL-3 withdrawal-induced apoptosis.

Original language	English
Pages (from-to)	412-417
Number of pages	6
Journal	European Journal of Haematology
Volume	71
Issue number	6
DOIs	https://doi.org/10.1046/j.0902-4441.2003.00160.x
Publication status	Published - 2003 Dec

Keywords

24p3
Apoptosis
Granulocyte colony stimulating factor
Interleukin 3
Stat3

ASJC Scopus subject areas

Hematology

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10.1046/j.0902-4441.2003.00160.x

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Kamezaki, K., Shimoda, K., Numata, A., Aoki, K., Kato, K., Takase, K., Nakajima, H., Ihara, K., Haro, T., Ishikawa, F., Imamura, R., Miyamoto, T., Nagafuji, K., Gondo, H., Hara, T., & Harada, M. (2003). The lipocalin 24p3, which is an essential molecule in IL-3 withdrawal-induced apoptosis, is not involved in the G-CSF withdrawal-induced apoptosis. European Journal of Haematology, 71(6), 412-417. https://doi.org/10.1046/j.0902-4441.2003.00160.x

The lipocalin 24p3, which is an essential molecule in IL-3 withdrawal-induced apoptosis, is not involved in the G-CSF withdrawal-induced apoptosis. / Kamezaki, Kenjirou; Shimoda, Kazuya; Numata, Akihiko; Aoki, Kenichi; Kato, Kouji; Takase, Ken; Nakajima, Hideaki; Ihara, Kenji; Haro, Takashi; Ishikawa, Fumihiko; Imamura, Rie; Miyamoto, Toshihiro; Nagafuji, Koji; Gondo, Hisashi; Hara, Toshiro; Harada, Mine.

In: European Journal of Haematology, Vol. 71, No. 6, 12.2003, p. 412-417.

Research output: Contribution to journal › Article › peer-review

Kamezaki, K, Shimoda, K, Numata, A, Aoki, K, Kato, K, Takase, K, Nakajima, H, Ihara, K, Haro, T, Ishikawa, F, Imamura, R, Miyamoto, T, Nagafuji, K, Gondo, H, Hara, T & Harada, M 2003, 'The lipocalin 24p3, which is an essential molecule in IL-3 withdrawal-induced apoptosis, is not involved in the G-CSF withdrawal-induced apoptosis', European Journal of Haematology, vol. 71, no. 6, pp. 412-417. https://doi.org/10.1046/j.0902-4441.2003.00160.x

Kamezaki, Kenjirou ; Shimoda, Kazuya ; Numata, Akihiko ; Aoki, Kenichi ; Kato, Kouji ; Takase, Ken ; Nakajima, Hideaki ; Ihara, Kenji ; Haro, Takashi ; Ishikawa, Fumihiko ; Imamura, Rie ; Miyamoto, Toshihiro ; Nagafuji, Koji ; Gondo, Hisashi ; Hara, Toshiro ; Harada, Mine. / The lipocalin 24p3, which is an essential molecule in IL-3 withdrawal-induced apoptosis, is not involved in the G-CSF withdrawal-induced apoptosis. In: European Journal of Haematology. 2003 ; Vol. 71, No. 6. pp. 412-417.

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abstract = "Many hematopoietic cells undergo apoptosis when deprived of specific cytokines. Lipocalin 24p3, reported to be induced in hematopoietic cells by interleukin 3 (IL-3) depletion, induces hematopoietic cell apoptosis despite the presence of IL-3. As granulocyte colony stimulating factor (G-CSF) depletion also induces the apoptosis of G-CSF-dependent cell line cells, we examined the effect of 24p3 on the apoptotic function induced by G-CSF depletion. 24p3 was induced by the depletion of IL-3, but not G-CSF, in cytokine-dependent cell lines. Although 24p3 suppressed growth induced by IL-3, it did not influence G-CSF-dependent cell growth. These observations show that 24p3 is not involved in the G-CSF withdrawal-induced apoptosis, although it is essential in IL-3 withdrawal-induced apoptosis.",

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AU - Aoki, Kenichi

AU - Kato, Kouji

AU - Takase, Ken

AU - Nakajima, Hideaki

AU - Ihara, Kenji

AU - Haro, Takashi

AU - Ishikawa, Fumihiko

AU - Imamura, Rie

AU - Miyamoto, Toshihiro

AU - Nagafuji, Koji

AU - Gondo, Hisashi

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AU - Harada, Mine

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AB - Many hematopoietic cells undergo apoptosis when deprived of specific cytokines. Lipocalin 24p3, reported to be induced in hematopoietic cells by interleukin 3 (IL-3) depletion, induces hematopoietic cell apoptosis despite the presence of IL-3. As granulocyte colony stimulating factor (G-CSF) depletion also induces the apoptosis of G-CSF-dependent cell line cells, we examined the effect of 24p3 on the apoptotic function induced by G-CSF depletion. 24p3 was induced by the depletion of IL-3, but not G-CSF, in cytokine-dependent cell lines. Although 24p3 suppressed growth induced by IL-3, it did not influence G-CSF-dependent cell growth. These observations show that 24p3 is not involved in the G-CSF withdrawal-induced apoptosis, although it is essential in IL-3 withdrawal-induced apoptosis.

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KW - Interleukin 3

KW - Stat3

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The lipocalin 24p3, which is an essential molecule in IL-3 withdrawal-induced apoptosis, is not involved in the G-CSF withdrawal-induced apoptosis

Abstract

Keywords

ASJC Scopus subject areas

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