The loss of Foxc2 expression in the outflow tract links the interrupted arch in the conditional Foxc2 knockout mouse

Mohammad Khaja Mafij Uddin; Wataru Kimura; Mohammed Badrul Amin; Kasumi Nakamura; Mohammod Johirul Islam; Hiroyuki Yamagishi; Naoyuki Miura

doi:10.1007/978-4-431-54628-3_27

The loss of Foxc2 expression in the outflow tract links the interrupted arch in the conditional Foxc2 knockout mouse

Mohammad Khaja Mafij Uddin, Wataru Kimura, Mohammed Badrul Amin, Kasumi Nakamura, Mohammod Johirul Islam, Hiroyuki Yamagishi, Naoyuki Miura

Department of Pediatrics

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Citation (Scopus)

Abstract

Congenital heart disease is the most common birth defects, affecting 1 % live births [1]. The cardiovascular system undergoes a series of morphogenetic events to form a heart and an aorta in fetuses. Formation of the heart and aorta requires migration, differentiation, and precise interactions among multiple cells from several embryonic origins [2]. Forkhead box2 (Foxc2) encodes a transcription factor and is expressed in mesodermal tissues, such as the pharyngeal artery, outflow tract endothelial/surrounding mesenchyme, bone, and kidney [3]. Simple knockout of Foxc2 in mouse causes an interrupted aortic arch, ventricular septal defect, cleft palate, and skeletal malformation [4]. The heart is made from primary and secondary heart field progenitors. The primary heart field gives rise to the left ventricle and atria, while the secondary heart field contributes mainly to the right ventricle and outflow tract [5] (Fig. 27.1).

Original language	English
Title of host publication	Etiology and Morphogenesis of Congenital Heart Disease
Subtitle of host publication	From Gene Function and Cellular Interaction to Morphology
Publisher	Springer Japan
Pages	211-213
Number of pages	3
ISBN (Electronic)	9784431546283
ISBN (Print)	9784431546276
DOIs	https://doi.org/10.1007/978-4-431-54628-3_27
Publication status	Published - 2016 Jan 1

Keywords

Conditional knockout
Foxc2
Interruption of aortic arch

ASJC Scopus subject areas

Medicine(all)
Biochemistry, Genetics and Molecular Biology(all)

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10.1007/978-4-431-54628-3_27

Cite this

Uddin, M. K. M., Kimura, W., Amin, M. B., Nakamura, K., Islam, M. J., Yamagishi, H., & Miura, N. (2016). The loss of Foxc2 expression in the outflow tract links the interrupted arch in the conditional Foxc2 knockout mouse. In Etiology and Morphogenesis of Congenital Heart Disease: From Gene Function and Cellular Interaction to Morphology (pp. 211-213). Springer Japan. https://doi.org/10.1007/978-4-431-54628-3_27

The loss of Foxc2 expression in the outflow tract links the interrupted arch in the conditional Foxc2 knockout mouse. / Uddin, Mohammad Khaja Mafij; Kimura, Wataru; Amin, Mohammed Badrul et al.
Etiology and Morphogenesis of Congenital Heart Disease: From Gene Function and Cellular Interaction to Morphology. Springer Japan, 2016. p. 211-213.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Uddin, MKM, Kimura, W, Amin, MB, Nakamura, K, Islam, MJ, Yamagishi, H & Miura, N 2016, The loss of Foxc2 expression in the outflow tract links the interrupted arch in the conditional Foxc2 knockout mouse. in Etiology and Morphogenesis of Congenital Heart Disease: From Gene Function and Cellular Interaction to Morphology. Springer Japan, pp. 211-213. https://doi.org/10.1007/978-4-431-54628-3_27

Uddin MKM, Kimura W, Amin MB, Nakamura K, Islam MJ, Yamagishi H et al. The loss of Foxc2 expression in the outflow tract links the interrupted arch in the conditional Foxc2 knockout mouse. In Etiology and Morphogenesis of Congenital Heart Disease: From Gene Function and Cellular Interaction to Morphology. Springer Japan. 2016. p. 211-213 doi: 10.1007/978-4-431-54628-3_27

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AB - Congenital heart disease is the most common birth defects, affecting 1 % live births [1]. The cardiovascular system undergoes a series of morphogenetic events to form a heart and an aorta in fetuses. Formation of the heart and aorta requires migration, differentiation, and precise interactions among multiple cells from several embryonic origins [2]. Forkhead box2 (Foxc2) encodes a transcription factor and is expressed in mesodermal tissues, such as the pharyngeal artery, outflow tract endothelial/surrounding mesenchyme, bone, and kidney [3]. Simple knockout of Foxc2 in mouse causes an interrupted aortic arch, ventricular septal defect, cleft palate, and skeletal malformation [4]. The heart is made from primary and secondary heart field progenitors. The primary heart field gives rise to the left ventricle and atria, while the secondary heart field contributes mainly to the right ventricle and outflow tract [5] (Fig. 27.1).

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The loss of Foxc2 expression in the outflow tract links the interrupted arch in the conditional Foxc2 knockout mouse

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