The Major Pectic Arabinogalactan Having Activity on the Reticuloendothelial System from the Roots and Rhizomes of Saposhnikovia divaricata

Noriko Shimizu, Masashi Tomoda, Ryoko Gonda, Mieko Kanari, Noriko Takanashi, Nahoko Takahashi

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Abstract

The major acidic polysaccharide, named saposhnikovan A, was isolated from the roots and rhizomes of Saposhnikovia divaricata. It showed remarkable reticuloendothelial system-potentiating activity in a carbon clearance test. It is composed of L-arabinose: d-galactose: D-galacturonic acid in the molar ratio of 6:15:10, and its molecular weight was estimated to be 54000. About 35 % of the D-galacturonic acid residues exist as the methyl esters. Methylation analysis, 13C-nuclear magnetic resonance, and controlled Smith degradation studies indicated that the polysac-charide has the α-l→4-linked D-galacturonan backbone bearing α-l→5-linked L-arabino-β-3,6-branched D-galactan side chains.

Original languageEnglish
Pages (from-to)1329-1332
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume37
Issue number5
DOIs
Publication statusPublished - 1989 Jan 1

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Keywords

  • 6-galactan immunological activity reticuloendothelial system methylation analysis controlled Smith degradation structural feature
  • Saposhnikovia divaricata polysaccharide saposhnikovan A pectic arabino-3

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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