The Many Faces of Tau

Meaghan Morris, Sumihiro Maeda, Keith Vossel, Lennart Mucke

Research output: Contribution to journalReview article

456 Citations (Scopus)

Abstract

While the microtubule-binding capacity of the protein tau has been known for many years, new functions of tau in signaling and cytoskeletal organization have recently emerged. In this review, we highlight these functions and the potential roles of tau in neurodegenerative disease. We also discuss the therapeutic potential of drugs targeting various aspects of tau biology.

Original languageEnglish
Pages (from-to)410-426
Number of pages17
JournalNeuron
Volume70
Issue number3
DOIs
Publication statusPublished - 2011 May 12
Externally publishedYes

Fingerprint

Drug Delivery Systems
Microtubules
Neurodegenerative Diseases
Carrier Proteins
Therapeutics

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Morris, M., Maeda, S., Vossel, K., & Mucke, L. (2011). The Many Faces of Tau. Neuron, 70(3), 410-426. https://doi.org/10.1016/j.neuron.2011.04.009

The Many Faces of Tau. / Morris, Meaghan; Maeda, Sumihiro; Vossel, Keith; Mucke, Lennart.

In: Neuron, Vol. 70, No. 3, 12.05.2011, p. 410-426.

Research output: Contribution to journalReview article

Morris, M, Maeda, S, Vossel, K & Mucke, L 2011, 'The Many Faces of Tau', Neuron, vol. 70, no. 3, pp. 410-426. https://doi.org/10.1016/j.neuron.2011.04.009
Morris M, Maeda S, Vossel K, Mucke L. The Many Faces of Tau. Neuron. 2011 May 12;70(3):410-426. https://doi.org/10.1016/j.neuron.2011.04.009
Morris, Meaghan ; Maeda, Sumihiro ; Vossel, Keith ; Mucke, Lennart. / The Many Faces of Tau. In: Neuron. 2011 ; Vol. 70, No. 3. pp. 410-426.
@article{08eee24832d246d2b668d450044f642c,
title = "The Many Faces of Tau",
abstract = "While the microtubule-binding capacity of the protein tau has been known for many years, new functions of tau in signaling and cytoskeletal organization have recently emerged. In this review, we highlight these functions and the potential roles of tau in neurodegenerative disease. We also discuss the therapeutic potential of drugs targeting various aspects of tau biology.",
author = "Meaghan Morris and Sumihiro Maeda and Keith Vossel and Lennart Mucke",
year = "2011",
month = "5",
day = "12",
doi = "10.1016/j.neuron.2011.04.009",
language = "English",
volume = "70",
pages = "410--426",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "3",

}

TY - JOUR

T1 - The Many Faces of Tau

AU - Morris, Meaghan

AU - Maeda, Sumihiro

AU - Vossel, Keith

AU - Mucke, Lennart

PY - 2011/5/12

Y1 - 2011/5/12

N2 - While the microtubule-binding capacity of the protein tau has been known for many years, new functions of tau in signaling and cytoskeletal organization have recently emerged. In this review, we highlight these functions and the potential roles of tau in neurodegenerative disease. We also discuss the therapeutic potential of drugs targeting various aspects of tau biology.

AB - While the microtubule-binding capacity of the protein tau has been known for many years, new functions of tau in signaling and cytoskeletal organization have recently emerged. In this review, we highlight these functions and the potential roles of tau in neurodegenerative disease. We also discuss the therapeutic potential of drugs targeting various aspects of tau biology.

UR - http://www.scopus.com/inward/record.url?scp=79955670132&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79955670132&partnerID=8YFLogxK

U2 - 10.1016/j.neuron.2011.04.009

DO - 10.1016/j.neuron.2011.04.009

M3 - Review article

C2 - 21555069

AN - SCOPUS:79955670132

VL - 70

SP - 410

EP - 426

JO - Neuron

JF - Neuron

SN - 0896-6273

IS - 3

ER -