TY - JOUR
T1 - The metabolic syndrome, IGF-1, and insulin action
AU - Arai, Yasumichi
AU - Kojima, Toshio
AU - Takayama, Michiyo
AU - Hirose, Nobuyoshi
N1 - Funding Information:
This work was supported in part by a grant to RIKEN GSC from the Ministry of Education, Culture, Sports, Science and Technology of Japan; the grant from the Ministry of Health, Welfare, and Labour for the Scientific Research Project for Longevity (Multidisciplinary approach to centenarians and its international comparison and research on healthy aging: Semisupercentenarians and Long-Lived Sibling Study; principal investigator, Nobuyoshi Hirose); the grant from Keio Health Consulting Center; and the grant from the Foundation for Total Health Promotion (2006).
PY - 2009/2/5
Y1 - 2009/2/5
N2 - Recent studies have shown that insulin and insulin-like growth factor (IGF)-1 signaling are involved in the control of ageing and longevity in model organisms. Based on these studies, genes involved in the insulin/IGF-1 signaling pathway are believed to play a role in longevity throughout evolution and could also be important in determining human longevity. However, human studies have yielded conflicting and controversial results. In human, defects in insulin receptor signaling cause insulin resistance and diabetes, and IGF-1 deficiency is associated with an increased risk of cardiovascular disease and atherosclerosis. Interestingly, insulin sensitivity normally decreases during aging; however, centenarians were reported to maintain greatly increased insulin sensitivity and had a lower prevalence of the metabolic syndrome as compared to younger subjects. Additionally, a longitudinal study revealed that insulin-sensitizing hormones, including leptin and adiponectin, were significantly associated with the survival of centenarians, indicating that an efficient insulin response may influence human longevity.
AB - Recent studies have shown that insulin and insulin-like growth factor (IGF)-1 signaling are involved in the control of ageing and longevity in model organisms. Based on these studies, genes involved in the insulin/IGF-1 signaling pathway are believed to play a role in longevity throughout evolution and could also be important in determining human longevity. However, human studies have yielded conflicting and controversial results. In human, defects in insulin receptor signaling cause insulin resistance and diabetes, and IGF-1 deficiency is associated with an increased risk of cardiovascular disease and atherosclerosis. Interestingly, insulin sensitivity normally decreases during aging; however, centenarians were reported to maintain greatly increased insulin sensitivity and had a lower prevalence of the metabolic syndrome as compared to younger subjects. Additionally, a longitudinal study revealed that insulin-sensitizing hormones, including leptin and adiponectin, were significantly associated with the survival of centenarians, indicating that an efficient insulin response may influence human longevity.
KW - Adipokines
KW - Aging
KW - Centenarian
KW - Insulin/IGF-1 signaling
KW - Longevity
KW - Metabolic syndrome
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U2 - 10.1016/j.mce.2008.07.002
DO - 10.1016/j.mce.2008.07.002
M3 - Article
C2 - 18672019
AN - SCOPUS:58349092062
VL - 299
SP - 124
EP - 128
JO - Molecular and Cellular Endocrinology
JF - Molecular and Cellular Endocrinology
SN - 0303-7207
IS - 1
ER -
