TY - JOUR
T1 - The MG-QOL15 Japanese version
T2 - Validation and associations with clinical factors
AU - masuda, Masayuki
AU - Utsugisawa, Kimiaki
AU - Suzuki, Shigeaki
AU - Nagane, Yuriko
AU - Kabasawa, Chiaki
AU - Suzuki, Yasushi
AU - Shimizu, Yuko
AU - Utsumi, Hiroya
AU - Fujihara, Kazuo
AU - Uchiyama, Shinichiro
AU - Suzuki, Norihiro
PY - 2012/8
Y1 - 2012/8
N2 - Introduction:: Our study aim was to produce a Japanese translation of the 15-item Myasthenia Gravis Quality-of-Life Scale (MG-QOL15), assess its reliability and validity, and examine clinical factors affecting self-perceived QOL in MG. Methods:: We evaluated 327 consecutive patients with MG seen at six neurological centers. All patients completed the Japanese version of the MG-QOL15 (MG-QOL15-J), the Beck Depression Inventory-second edition (BDI-II), and a generic health-related QOL questionnaire, the SF-36. Disease severity was determined according to the Myasthenia Gravis Foundation of America (MGFA) quantitative MG score and the MG composite. Results:: The MG-QOL15-J exhibited adequate internal reliability, test-retest repeatability, and concurrent validity with SF-36, disease severity, and known-patient groups categorized by MGFA post-intervention status. Multivariate analysis revealed severity, dose of oral corticosteroids, and BDI-II as independent factors negatively affecting QOL. Conclusion:: The MG-QOL15-J is anticipated to be a valuable clinical measure of QOL in Japanese patients with MG.
AB - Introduction:: Our study aim was to produce a Japanese translation of the 15-item Myasthenia Gravis Quality-of-Life Scale (MG-QOL15), assess its reliability and validity, and examine clinical factors affecting self-perceived QOL in MG. Methods:: We evaluated 327 consecutive patients with MG seen at six neurological centers. All patients completed the Japanese version of the MG-QOL15 (MG-QOL15-J), the Beck Depression Inventory-second edition (BDI-II), and a generic health-related QOL questionnaire, the SF-36. Disease severity was determined according to the Myasthenia Gravis Foundation of America (MGFA) quantitative MG score and the MG composite. Results:: The MG-QOL15-J exhibited adequate internal reliability, test-retest repeatability, and concurrent validity with SF-36, disease severity, and known-patient groups categorized by MGFA post-intervention status. Multivariate analysis revealed severity, dose of oral corticosteroids, and BDI-II as independent factors negatively affecting QOL. Conclusion:: The MG-QOL15-J is anticipated to be a valuable clinical measure of QOL in Japanese patients with MG.
KW - Cross-sectional study
KW - Health-related quality of life
KW - Myasthenia gravis
KW - Questionnaire
KW - Validity
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U2 - 10.1002/mus.23398
DO - 10.1002/mus.23398
M3 - Article
C2 - 22806364
AN - SCOPUS:84863992083
SN - 0148-639X
VL - 46
SP - 166
EP - 173
JO - Muscle and Nerve
JF - Muscle and Nerve
IS - 2
ER -