The MG-QOL15 Japanese version: Validation and associations with clinical factors

Masayuki masuda, Kimiaki Utsugisawa, Shigeaki Suzuki, Yuriko Nagane, Chiaki Kabasawa, Yasushi Suzuki, Yuko Shimizu, Hiroya Utsumi, Kazuo Fujihara, Shinichiro Uchiyama, Norihiro Suzuki

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Abstract

Introduction:: Our study aim was to produce a Japanese translation of the 15-item Myasthenia Gravis Quality-of-Life Scale (MG-QOL15), assess its reliability and validity, and examine clinical factors affecting self-perceived QOL in MG. Methods:: We evaluated 327 consecutive patients with MG seen at six neurological centers. All patients completed the Japanese version of the MG-QOL15 (MG-QOL15-J), the Beck Depression Inventory-second edition (BDI-II), and a generic health-related QOL questionnaire, the SF-36. Disease severity was determined according to the Myasthenia Gravis Foundation of America (MGFA) quantitative MG score and the MG composite. Results:: The MG-QOL15-J exhibited adequate internal reliability, test-retest repeatability, and concurrent validity with SF-36, disease severity, and known-patient groups categorized by MGFA post-intervention status. Multivariate analysis revealed severity, dose of oral corticosteroids, and BDI-II as independent factors negatively affecting QOL. Conclusion:: The MG-QOL15-J is anticipated to be a valuable clinical measure of QOL in Japanese patients with MG.

Original languageEnglish
Pages (from-to)166-173
Number of pages8
JournalMuscle and Nerve
Volume46
Issue number2
DOIs
Publication statusPublished - 2012 Aug

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Keywords

  • Cross-sectional study
  • Health-related quality of life
  • Myasthenia gravis
  • Questionnaire
  • Validity

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)
  • Physiology

Cite this

masuda, M., Utsugisawa, K., Suzuki, S., Nagane, Y., Kabasawa, C., Suzuki, Y., Shimizu, Y., Utsumi, H., Fujihara, K., Uchiyama, S., & Suzuki, N. (2012). The MG-QOL15 Japanese version: Validation and associations with clinical factors. Muscle and Nerve, 46(2), 166-173. https://doi.org/10.1002/mus.23398